The Health-Related Quality of Life, Work Productivity, Healthcare Resource Utilization, and Economic Burden Associated with Levels of Suicidal Ideation Among Patients Self-Reporting Moderately Severe or Severe Major Depressive Disorder in a National Survey

Benson, Carmela; Singer, David; Carpinella, Colleen M.; Shawi, M.; Alphs, Larry

doi:10.2147/ndt.s229530

Cited by 23 publications

(8 citation statements)

References 40 publications

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“…Our study demonstrated that HBP was associated with past-year suicidal ideation among currently employed individuals probably because of pressure at work [ 50 , 54 ] or work dissatisfaction [ 55 ], which may impair an individual’s ability to cope, resulting in suicidal ideation. The findings are congruent with those in the literature [ 56 ]; however, the identification of currently employed individuals as a high-risk group for past-year suicidal ideation is unique.…”

Section: Discussionsupporting

confidence: 88%

Association of chronic diseases and lifestyle factors with suicidal ideation among adults aged 18–69 years in Eswatini: evidence from a population-based survey

2021

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Background How chronic diseases and lifestyle affect suicidal ideation in the sub-Saharan region remains unclear. We investigated the association of chronic diseases and lifestyle with suicidal ideation in the past year and the potential modifying role of sociodemographic status on this association. The findings can guide suicide prevention interventions. Methods We analyzed 3026 respondents from the World Health Organization STEPwise approach to noncommunicable disease risk factor surveillance conducted in Eswatini in 2014. The outcome was past-year suicidal ideation, and the main predictors were chronic diseases and lifestyle. Multiple logistic regression was used to estimate predictors, and subgroup analysis was performed to assess effect modification. Results The prevalence of past-year suicidal ideation was 9.9%. After adjustment for covariates, including sex, marital status, employment status, and education level, individuals aged 18–30 years (adjusted odds ratio [aOR]: 2.27, 95% confidence interval [CI]: 1.22–4.22) were more likely to have had past-year suicidal ideation than those aged 45–69 years. After adjustment for covariates among employed individuals, having high blood pressure (aOR: 3.38, 95% CI: 1.54–7.40), not exercising (aOR: 2.65, 95% CI: 1.09–6.39), drinking alcohol (aOR: 2.40, 95% CI: 1.14–5.05), being aged 18–30 years (aOR: 3.50, 95% CI: 1.01–12.1), and being exposed to threats (aOR: 2.37, 95% CI: 1.01–5.53) were significantly associated with past-year suicidal ideation. Conclusions Among currently employed individuals, having high blood pressure, not exercising, and drinking alcohol were associated with past-year suicidal ideation. The findings highlight the importance of developing and strengthening systems for early identification of suicidal ideation risk.

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Section: Discussionsupporting

confidence: 88%

Association of chronic diseases and lifestyle factors with suicidal ideation among adults aged 18–69 years in Eswatini: evidence from a population-based survey

2021

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“…Major depressive disorder (MDD) is a complex and recurrent neuropsychiatric disease, which is mainly associated with loss of occupational role and quality of life of patients, contributing to economic burden and public health problems (Benson, Singer, Carpinella, Shawi, & Alphs, 2021; Bromet et al, 2011; Pazini, Cunha, & Rodrigues, 2019). According to the World Health Organization, MDD affects more than 264 million people worldwide, and its effects can be recurrent and enduring, seriously influencing the individual's ability to function and live a profitable life (World Health Organization, 2020).…”

Section: Introductionmentioning

confidence: 99%

Antidepressant‐like effect of rosmarinic acid during LPS‐induced neuroinflammatory model: The potential role of cannabinoid receptors/PPAR‐γ signaling pathway

Lataliza

Assis

Laurindo

et al. 2021

Phytotherapy Research

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Rosmarinic acid (RA), an ester of caffeic acid and 3, 4-dihydroxyphenyllactic acid, has anti-inflammatory and neuroprotective activities. Herein, this study investigated in silico the drug-likeness and the potential molecular targets to RA. Moreover, it tested the antidepressant-like potential of RA in the lipopolysaccharide (LPS)-induced depression model. RA (MW = 360.31 g/mol) meets the criteria of both Lipinski's rule of five and the Ghose filter. It also attends to relevant pharmacokinetic parameters.Target prediction analysis identified RA's potential targets and biological activities, including the peroxisome proliferator-activated receptor (PPAR) and the cannabinoid receptors CB 1 and CB 2 . In vivo, RA's acute, repetitive, and therapeutic administration showed antidepressant-like effect since it significantly reduced the immobility time in the tail suspension test and increased grooming time in the splash test. Further, the pretreatment with antagonists of CB 1 , CB 2 , and PPAR-γ receptors significantly blocked the antidepressant-like effect of RA. Altogether, our findings suggest that cannabinoid receptors/PPAR-γ signaling pathways are involved with the antidepressant-like effect of RA. Moreover, this molecule meets important physicochemical and pharmacokinetic parameters that favor its bioavailability. RA constitutes a promising, innovative, and safe molecule for the pharmacotherapy of major depressive disorder.

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“…The treatment of patients with depression with suicidal ideation or suicidal attempts is particularly challenging due to the urgency of the condition, the need to for immediate interventions to save lives and the limited treatment options. In addition, patients with suicidality suffer from poorer quality of life and social functioning than patients with MDD without suicidality [ 10 – 12 ]. Treating MDD patients contemplating suicide is a complicated problem that requires physicians to treat not just the depression, or to simply consider these patients as having a severe subtype of major depression, but instead to consider the suicidality itself as a distinct condition which warrants its own consideration [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment patterns of patients diagnosed with major depressive disorder and suicidal ideation or attempt: a U.S. population-based study utilizing real-world data

2021

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Background There is a knowledge gap regarding the treatment patterns of patients with major depressive disorder (MDD) who experience suicidal ideation or a suicide attempt (SI/SA). Methods Patients with SI/SA were identified from a large US-based claims database covering 84 million lives, during 1/1/2014–3/31/2020. Patients with MDD were indexed at their first diagnosis for SI/SA and followed up to 365 days. Treatment patterns were captured at the class level and included procedures of electroconvulsive therapy and transcranial magnetic stimulation, and pharmacotherapy including selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors, tricyclic antidepressants, other antidepressants, anxiolytics, hypnotics/sedatives, antipsychotics, psychostimulants, and lithium. Results There were 42,204 MDD + SI/SA patients identified. In the year prior to the index event > 40% of individuals received an SSRI and more than one-third received an anxiolytic. Within 1 year following, 84.4% received ≥1 of the treatments of interest. Of those, 70.2% went on to a subsequent class-based regimen, 46.3% received a third, and 28.1% received ≥4. More than three-quarters of patients received multiple treatment classes simultaneously. SSRIs were the most common treatments during follow-up (61.9%), followed by other antidepressants (51.3%), anxiolytics (50.8%) and anticonvulsants (43.6%). Conclusions There was a large amount of variability and polypharmacy in the treatments received by MDD patients with SI/SA, and is much more complex than what has been previously observed in the general MDD population. Within one-year, many patients received four or more unique class-based regimens and most patients received treatments from multiple classes simultaneously, indicating the high unmet medical need and therapy refractoriness of this patient population.

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The Health-Related Quality of Life, Work Productivity, Healthcare Resource Utilization, and Economic Burden Associated with Levels of Suicidal Ideation Among Patients Self-Reporting Moderately Severe or Severe Major Depressive Disorder in a National Survey

Cited by 23 publications

References 40 publications

Association of chronic diseases and lifestyle factors with suicidal ideation among adults aged 18–69 years in Eswatini: evidence from a population-based survey

Association of chronic diseases and lifestyle factors with suicidal ideation among adults aged 18–69 years in Eswatini: evidence from a population-based survey

Antidepressant‐like effect of rosmarinic acid during LPS‐induced neuroinflammatory model: The potential role of cannabinoid receptors/PPAR‐γ signaling pathway

Treatment patterns of patients diagnosed with major depressive disorder and suicidal ideation or attempt: a U.S. population-based study utilizing real-world data

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