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© Copyright 2017 RAND CorporationR® is a registered trademark.iii Preface Ensuring patients' survival and curing disease are no longer the sole goals of patient care; functional status and well-being must also be optimized. Standardized assessments through patient-reported outcome (PRO) performance measures (PMs) allow evaluators to see how well these aspects of care are being delivered and compare the performance of health care systems and different provider groups.To meaningfully assess health-related quality of life, PMs must align with patients' goals. Most PMs in current use assess technical quality of care, the benefit of which can take years to realize. These sorts of measures might not be particularly salient to older adults (especially age 80 and older) with multiple chronic conditions (MCC) because their expectations for long-term survival are limited. The desire of such patients to maximize quality of life for the remainder of their life spans is obviously undiminished. However, no PMs have been formally developed or validated for use in this population. Therefore, policymakers and researchers who focus on quality of health care are especially interested in developing PRObased PMs to measure the care delivered to older adults with MCC.This project aimed to address this gap in validated PRO-based PMs through the completion of two aims. The first aim was to determine whether the Patient-Reported Outcomes Measurement Information System 29-item (PROMIS-29) profile instrument is valid for use in this population. The second aim was to study how well PMs based on PROs, specifically the Veterans RAND 36 Item Health Survey (VR-36) and the PROMIS-29, measure functional status and well-being in the same population. This report summarizes our analyses and provides recommendations for future efforts to develo...