ABSTRACT:A comparative study was done on haemodynamic changes between 60 healthy pregnant women each of whom carried a single foetus and 20 non pregnant healthy women by using echocardiography. Heart rate, blood pressure, cardiac output, ejection fraction, fractional shortening, aortic flow, and pulmonary flow were taken as parameters and compared. The increase of heart rate in pregnant women is highly significant when compared to that of non-pregnant women. The systolic blood pressure and diastolic blood pressure decreased in the 1 st &2 nd trimesters of pregnancy and the systolic blood pressure returned to non pregnant levels in the 3 rd trimester. The cardiac output, ejection fraction, fractional shortening, aortic flow and pulmonary flows were increased in the 1 st , 2 nd and 3 rd trimesters of pregnancy when compared to non pregnant women.
INTRODUCTION:Pregnancy (Latin word -graviditus) is the carrying of one or more offspring known as fetus (or) embryo inside the uterus of a female human. Pregnancy is a physiological phenomenon which is self limited and is of 38-40 weeks in humans which is divided into 3 trimesters. Pregnancy produces numerous anatomical and physiological changes in the females. The major changes involve the reproductory organs, cardiovascular system, hemopoietic system, respiratory system and excretory system. Many of the maternal changes associated with pregnancy involve the cardiovascular system. The understanding these adaptations to pregnancy is an important applied aspect of physiology.During normal pregnancy significant vascular and hemodynamic adjustments occur. Pregnancy is associated with volume overload producing alteration in cardiovascular physiology (4). Most important changes occur in the first 8 wks of pregnancy (5). In normal women, the blood volume at or very near term averaged about 40-45% above their non pregnant levels (6). Pregnancy induced hypervolemia helps to meet the demands of enlarged uterus and protect the mother (10). Maternal blood volume expands more rapidly during 2nd trimester and then at slower rate during 3rd trimester (1). Increase in red cell mass as much as 40% above pre-pregnant levels (8) and increase of maternal plasma erythropoietin levels which peaks during early 3rd trimester (2) allow the cardiovascular system to meet the increased metabolic demands of pregnancy.