The Heart Rate Following Edrophonium-Atropine and Edrophonium-Glycopyrrolate Mixtures

Cardiovascular and autonomic nervous effects of edrophonium and atropine combinations during neuromuscular blockade antagonism in sheep

“…The overall AN effect of anticholinesterase–antimuscarinic drug mixtures depends on the specific components of the mixture (Azar et al. 1983), their autonomic potency (and therefore, respective doses) (Clutton et al.…”

“…Matching components with similar pharmacokinetic properties is important in avoiding complications. Both edrophonium and atropine have a rapid onset and a short duration of action; their combination caused little HR disturbance in humans (Azar et al. 1983).…”