The heart rate recovery is impaired in participants with premature ejaculation

Turan, Yaşar; Gürel, Abdullah

doi:10.1111/and.13573

Cited by 9 publications

(14 citation statements)

References 31 publications

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“…Firstly, decreased erectile functioning could be a motivator to seek excitation transfer: One needs stronger stimuli to achieve sexual arousal or gratification (Smid & Wever, 2019). Also, higher sympathetic arousal has been related to smaller erections (Harte, 2013), less orgasms through normal intercourse (Costa & Brody, 2012), and more problematic erectile functioning (Rowland, 2010;Turan & Gürel, 2020). Therefore, we hypothesized that excitation transfer would be associated with decreased erectile functioning and increased resting state sympathetic arousal.…”

Section: The Current Studymentioning

confidence: 99%

Excitation Transfer Between Sexual Arousal and Other Emotions in a Community Sample

Schippers

Smid²,

Both

et al. 2022

Arch Sex Behav

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Section: The Current Studymentioning

confidence: 99%

Excitation Transfer Between Sexual Arousal and Other Emotions in a Community Sample

Schippers

Smid²,

Both

et al. 2022

Arch Sex Behav

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“…In the ejaculation phase, the sympathetic nervous system facilitates the emission of seminal uid [15]. There are a few preliminary studies suggesting a role for sympathovagal imbalance in PE, with men with PE displaying higher levels of sympathetic activation than sexually functional controls in both non-aroused [16,17] and aroused [18] settings. In the case of autonomic imbalance, sympathetic overactivity might inhibit erection and facilitate ejaculation.…”

Section: Pe and Edmentioning

confidence: 99%

“…There are ve categories of ED based on IIEF-5 scores: Severe (5-7), moderate (8-11), mild to moderate (12)(13)(14)(15)(16), mild (17)(18)(19)(20)(21), and no ED (22)(23)(24)(25) [67].…”

Section: Penile Characteristicsmentioning

confidence: 99%

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Self-Reported Anatomical Characteristics of the Penis and Male Sexual Function

Niu

Ventus²,

Jern³

et al. 2022

Preprint

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Premature ejaculation (PE) and erectile dysfunction (ED), which is common male sexual dysfunctions worldwide, lead to substantial distress in men as well as their partners, and decrease the quality and stability of romantic relationships, and, consequently, lead to a decreased quality of life in a large part of the population. We investigated the associations between self-reported anatomical characteristics of the penis and PE and ED in an urban Chinese sample. We recruited 1976 Chinese urban men aged 18 to 50 to fill out an online questionnaire regarding demographic information, anatomical characteristics of the penis, as well as PE and ED. Participants reported their age, penile length, penile circumference, circumcision status, and foreskin characteristics as well as answered the International Index of Erectile Function-5 (IIEF-5) and Checklist for Early Ejaculation Symptoms (CHEES). Penile length and girth were associated with less ejaculatory problems, but only penile length was associated with less erectile problems. Results showed that overall higher age was associated with less ejaculatory and erectile problems. This pattern was confirmed in the younger group (age < = 31) where higher age was associated with less ejaculatory and erectile problems. However, in the older group (age > 31), higher age was associated with more ejaculatory and erectile problems. The relationship between penile length and sexual function did not change with age whereas penile girth was associated with less ejaculatory problems in the older age group only. Male circumcision and less foreskin covering the glans penis were associated with less ejaculatory and erectile problems. The present study is the first study to investigate the association between anatomical characteristics of the penis (penis size and circumcision) and sexual function. However, the self-reported measurement of penis size is a potential limitation. the penis size was measured by self-reported. There is a potential limitation to the reliability of such self-reports. The results indicated that the relationship between the anatomical characteristics of the penis and sexual function was complex. Also, the effects of age on sexual function were positive among younger men and negative among older men.

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“…24 Moreover, heart rate recovery after intense exercise has been found to be slower in men diagnosed with premature ejaculation than in controls, again suggesting an overactive sympathetic system. 25 Finally, a study of the sympathetic skin response on the penis showed that it was enhanced in men suffering from premature ejaculation. 26 All these observations coincide with data from male rats.…”

Section: Introductionmentioning

confidence: 99%

Sexual Incentive Motivation and Copulatory Behavior in Male Rats Treated with the Adrenergic α2-Adrenoceptor Agonists Tasipimidine and Fadolmidine: Implications for Treatment of Premature Ejaculation

Lehtimäki

Ventura-Aquino²,

Chu

et al. 2021

The Journal of Sexual Medicine

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Background: Premature ejaculation is the most common sexual dysfunction in young men, and it often leads to reduced relationship satisfaction and quality of life.Aim: To determine the role of central and peripheral α2-adrenoceptors in the control of ejaculation and sexual incentive motivation in rats.Methods: Sexual incentive motivation was studied in a large arena in which a male subject could choose between approaching and remaining close to a sexually receptive female or another male.Sexual behavior was studied in standard observation cages in which a male was allowed to freely interact with a receptive female for 30 min. Two highly selective agonists at the α2-adrenoceptors, tasipimidine and fadolmidine, were administered before the tests. Low peripheral doses of fadolmidine has been reported to have effects mainly outside of the central nervous system, whereas at large doses also the central effects are evident. Outcomes:The time spent close to the receptive female in relation to the time spent with the male and measures of ambulatory activity were obtained from the test for sexual incentive motivation, while the habitual parameters of sexual behavior were recorded with the copulation test.Results: Tasipimidine prolonged ejaculation latency and the interintromission interval at the dose of 200 µg/kg when data from fast-ejaculating rats were used. No other sexual parameter was modified. A dose of 100 µg/kg was ineffective. There was no consistent effect on sexual incentive motivation, although modest sedation was observed. Fadolmidine, a drug that does not easily penetrate the blood-brain barrier, had no effect on sexual incentive motivation at any of the doses used (3, 30, and 100 µg/kg). The largest dose had clear sedative effects. The lower doses had no systematic effect on sexual behavior, not even when only fast or very fast ejaculating males were analyzed. Clinical Translation:The findings are relevant to the search for treatments for premature ejaculation that are specific enough to selectively delay ejaculation. Strengths & Limitations:The procedures used here are standard in the field and yield the most reliable data. Whether the effects observed in male rats are directly transferrable to men can only be determined through clinical studies. Conclusion:The observation that drugs acting at central but not peripheral α2-adrenoceptors prolong ejaculation latency without affecting any other parameter of sexual behavior or sexual incentive motivation suggests that this kind of drug may be suitable for treating premature ejaculation.

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The heart rate recovery is impaired in participants with premature ejaculation

Cited by 9 publications

References 31 publications

Excitation Transfer Between Sexual Arousal and Other Emotions in a Community Sample

Excitation Transfer Between Sexual Arousal and Other Emotions in a Community Sample

Self-Reported Anatomical Characteristics of the Penis and Male Sexual Function

Sexual Incentive Motivation and Copulatory Behavior in Male Rats Treated with the Adrenergic α2-Adrenoceptor Agonists Tasipimidine and Fadolmidine: Implications for Treatment of Premature Ejaculation

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