The Heart Rate Response to Exercise Is Blunted in Patients with Sleep-Related Breathing Disorder

Grote, Ludger; Hedner, Jan; Peter, J. H.

doi:10.1159/000077911

Cited by 34 publications

(35 citation statements)

References 24 publications

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“…Patients with OSA have lower HR recovery after peak exercise compared with healthy individuals, and this impaired chronotropic response is directly related to the severity of OSA (4,11). Although our results did not show statistical differences in HR recovery between both groups, we observed that patients with moderate-to-severe OSA had a tendency to show a blunted HR recovery at 90 seconds after workload and that AHI and DI were almost significantly correlated to this slower HR recovery.…”

Section: Correlations Between Sleep Register and Cardiopulmonary Exercontrasting

confidence: 69%

“…Several studies have reported that exercise capacity in patients with OSA is not differ registered in healthy subjects (7 these results conflict with many other reports that have described higher maximal V'O2 in non OSA populations (2)(3)(4)(5)(6)22). Reinforcing this last observation, some studies have shown inversely correlated with peak V'O2 during CPET (3,5,22,23).…”

Section: Discussionmentioning

confidence: 82%

“…Finally, sleep fragmentation and excessive diurnal somnolence of those with OSA could be related to decreased daily activity and lack of fitness, resulting in submaximal efforts during CPET The cardiovascular response to exercise in patients nuated in several studies (3,5,7,11). Patients with OSA have lower HR recovery after peak exercise compared with healthy individuals, and this impaired chronotropic response is directly related to the severity of OSA (4,11). Although ow statistical differences in HR recovery between both groups, we observed that severe OSA had a tendency to show a blunted HR recovery at 90 seconds after workload and that AHI and DI were almost slower HR recovery.…”

Section: Correlations Between Sleep Register and Cardiopulmonary Exermentioning

confidence: 99%

“…A person's sex also has an influence on exercise capacity, which could be at least 20%-40% lower in women than in men (15). These variables have not always been considered, however, when interpreting the results of studies that have evaluated exercise capacity in patients with OSA (2)(3)(4)(5)(6)(7)(8)(9)(10)12). Moreover, these reports have included only a small number of women; therefore, their results might not extend to this population.…”

Section: Introductionmentioning

confidence: 99%

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Exercise capacity and heart rate recovery response to exercise in morbidly obese female patients with obstructive sleep apnoea syndrome.

et al. 2017

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INTRODUCTION:To study exercise capacity and heart rate (HR) recovery after peak exercise in morbidly obese female patients with obstructive sleep apnoea (OSA). METHODS:Twenty-four morbidly obese female patients (36.17 ± 9.20 years and 45.20 ± 5.41 kg.m diagnosed with OSA underwent cardiopulmonary exercise testing (CPET) for assessment of peak oxygen uptake (V'O2) and heart rate (HR) recovery at 30, 60 a index [AHI] <15 h-1) and moderate-to-severe (AHI RESULTS: For the entire study population, peak V'O2 was 15.58 ± 2.44 ml.min were found between moderate-to-severe and mild OSA (16.11 ± 2.37 vs. 15.19 ± 2.50 ml.min respectively). HR recovery registered at any time after the peak workload also did not differ between both groups. Nonetheless, the percentage of HR decrease at 90 seconds in the patients with moderate-to-severe OSA (p=.073), and it was negatively correlated with the oxygen desaturation index (r =-0.679, p=.044). CONCLUSION:Exercise capacity is not different bet Nevertheless, patients with moderatethose with milder OSA. Finally, the oxygen desaturation index is related to this slower chron Keywords: Obstructive sleep apnoea, Exercise test, Female, Heart rate, Obesity. Received March 20, 2017; Accepted May 11, 2017 Copyright: © 2017 Authors. This is an open License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and sourc credited. Editor: Javier Jareño Cite as: Carpio C., Santiago A., Gómez-Mendieta M., Caballero P., Martín capacity and heart rate recovery response to exercise in morbidly obese female patients with obstructive sleep apnoea syndrom IBJ Plus 2017 1(1):e0004. Funding: The author(s) declared that no grants were involved in supporting this work. To study exercise capacity and heart rate (HR) recovery after peak exercise in morbidly obese female patients with obstructive sleep apnoea (OSA).four morbidly obese female patients (36.17 ± 9.20 years and 45.20 ± 5.41 kg.m diagnosed with OSA underwent cardiopulmonary exercise testing (CPET) for assessment of peak oxygen uptake (V'O2) and heart rate (HR) recovery at 30, 60 and 90 seconds. Comparisons were made between mild (apnoea severe (AHI ≥15 h-1) OSA.For the entire study population, peak V'O2 was 15.58 ± 2.44 ml.min-1.kg-1. No differences in peak V'O2 severe and mild OSA (16.11 ± 2.37 vs. 15.19 ± 2.50 ml.min respectively). HR recovery registered at any time after the peak workload also did not differ between both groups. Nonetheless, the percentage of HR decrease at 90 seconds of recovery time was almost statistically significantly lower severe OSA (p=.073), and it was negatively correlated with the oxygen desaturation Exercise capacity is not different between patients with mild and moderate -to-severe OSA tend to have a slower HR recovery response to exercise than those with milder OSA. Finally, the oxygen desaturation index is related to this slower chronotropic response.Obstructive sleep apnoea, Exercise test, Female, Heart rate, Obesity.May 11, 2017; Published May 23, 2017...

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Section: Correlations Between Sleep Register and Cardiopulmonary Exercontrasting

confidence: 69%

Section: Discussionmentioning

confidence: 82%

Section: Correlations Between Sleep Register and Cardiopulmonary Exermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Exercise capacity and heart rate recovery response to exercise in morbidly obese female patients with obstructive sleep apnoea syndrome.

et al. 2017

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“…These abnormal CPET responses are reduced cardiorespiratory fitness (V'O 2 ), exaggerated systolic (SBP) and/or diastolic blood pressure (DBP), chronotropic impairment (e.g. high HR reserve), impaired ventilatory equivalents for oxygen (V'E/V'O 2 ), impaired ventilatory equivalents for carbon dioxide (V'E/V'CO 2 ) at submaximal and maximal workloads, and blunt heart rate recovery (HRR) at peak exercise (Aron, Zedalis, Gregg, Gwazdauskas, & Herbert, 2009;Grote, Hedner, & Peter, 2004;Hargens et al, 2009;Nanas et al, 2010;Vanhecke et al, 2008). However, a few studies have reported similar V'O 2peak , HR reserve, SBP, and DBP at peak exercise between OSA patients and controls (Alonso-Fernandez et al, 2006;Hargens et al, 2008;Kaleth et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Performance Following Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea

Wuttiumporn¹,

Khrisanapant²,

Pasurivong³

et al. 2017

Sleep Hypn

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Heart Rate Recovery and Oxygen Kinetics After Exercise in Obstructive Sleep Apnea Syndrome

Nanas

Sakellariou

Kapsimalakou

et al. 2010

Clinical Cardiology

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Background: Patients who suffer from obstructive sleep apnea (OSA) have a decreased exercise capacity and abnormal autonomic nervous function. However, the kinetics of early oxygen (O 2 ) and heart rate recovery (HRR) have not been described. Materials and Methods:We evaluated 21 men with moderate to severe OSA (mean age: 48 ± 11 yrs, mean apnea-hypopnea index [AHI]: 55 ± 13) and without known heart disease and 10 healthy men matched for age and body mass index (BMI; controls). Men with OSA underwent overnight polysomnography, and both groups underwent symptom-limited incremental cardiopulmonary exercise testing (CPET). We recorded the CPET parameters including peak O 2 uptake (VO 2 p), kinetics of early O 2 recovery by the first degree slope of VO 2 during the first minute (VO 2 /t slope), the time required for a 50% decline of VO 2 p during recovery (T 1/2 ), and early heart rate recovery (HRR = HR at maximal exercise − HR at 1 min of recovery), as well as the chronotropic reserve to exercise ([CR] = [peak HR − resting HR/220 − age − resting HR] × 100). Patients with OSA had a lower VO 2 p (28.7 ± 4.0 vs 34.7 ± 6.2 mL/kg/min), VO 2 /t slope (1.04 ± 0.3 vs 1.4 ± 0.17 mL/kg/min 2 ), and T 1/2 (74 ± 10 vs 56 ± 6 sec) compared to controls (all P < 0.001). In addition, both HRR and CR were lower in the OSA group (22.0 ± 7.0 vs 31.0 ± 6.0 bpm,P:0.003, and 79.0% ± 15% vs 99.0% ± 13.0%, P:0.01, respectively). Conclusions: Patients with OSA demonstrate reduced exercise capacity, delayed oxygen kinetics, and reduced HRR. These data point to abnormal oxygen delivery and/or oxidative function of the peripheral muscles and impaired autonomic nervous activity in OSA patients.

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The Heart Rate Response to Exercise Is Blunted in Patients with Sleep-Related Breathing Disorder

Cited by 34 publications

References 24 publications

Exercise capacity and heart rate recovery response to exercise in morbidly obese female patients with obstructive sleep apnoea syndrome.

Exercise capacity and heart rate recovery response to exercise in morbidly obese female patients with obstructive sleep apnoea syndrome.

Cardiovascular Performance Following Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea

Heart Rate Recovery and Oxygen Kinetics After Exercise in Obstructive Sleep Apnea Syndrome

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