The properties of the nucleons in nuclear medium have been investigated in the context of the flux tube model incorporating strangeness (ss) contribution to proton structure in conformity with the experimental indication.Proton is described as a pentaquark system with strange quark contribution whereas neutron is described in three quark configuration. The Quasi particle model of diquark is used to describe the structures of the nucleons. Modifications of the properties like swelling, mass, incompressibility, ratio of the structure functions (), Gottfried Sum rule for nucleons in nuclear medium have been studied and significant effects have been observed. It has been suggested that the change of the size degree of freedom of the nucleon in the nuclear medium plays an important role in describing the properties in medium. The results are discussed in detail and compared with existing experimental and theoretical predictions. Some interesting observations are made.