“The Heidelberg Five” Personality Dimensions: Genome-wide Associations, Polygenic Risk for Neuroticism, and Psychopathology 20 Years after Assessment

Heilbronner, Urs; Papiol, Sergi; Budde, Monika; Andlauer, Till F. M.; Strohmaier, Jana; Streit, Fabian; Frank, Josef; Degenhardt, Franziska; Nöthen, Markus M.; Witt, Stephanie H.; Forstner, Andreas J.; Loerbroks, Adrian; Amelang, Manfred; Stuermer, Til; Mueller-Myhsok, Bertram; Nöethen, Markus M.; Rietschel, Marcella; Schulze, Thomas G.

doi:10.1101/2020.03.23.003889

Cited by 1 publication

(2 citation statements)

References 55 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, it has been noted that extroverts may be more likely to become friend controls 26 . That being said, to date, none of the genetic studies of extraversion have identified genes that overlap with those associated with HG 34,35 . In addition, a search of 4220 GWASs for GDF15 associations did not identify any personality traits, but did identify protein levels, periodontitis and lupus 36 .…”

Section: Discussionmentioning

confidence: 99%

“…26 That being said, to date, none of the genetic studies of extraversion have identified genes that overlap with those associated with HG. 34,35 In addition, a search of 4220 GWASs for GDF15 associations did not identify any personality traits, but did identify protein levels, periodontitis and lupus. 36 We can think of no reason for any of these associated factors to be biased by the selection of acquaintance controls.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

See 1 more Smart Citation

Whole‐exome sequencing uncovers new variants in GDF15 associated with hyperemesis gravidarum

Fejzo

MacGibbon

First

et al. 2022

BJOG

View full text Add to dashboard Cite

Objective: A genome-wide association study (GWAS) linked the placenta and appetite hormone gene GDF15 to hyperemesis gravidarum (HG). This paradigmchanging finding has shifted the field away from the prevailing hypotheses, but more evidence is needed. This study was performed to identify coding variants in addition to the non-coding variants implicated by GWAS.Setting: Case-control research study performed in a university setting.Design: Case-control study.Population: Hyperemesis gravidarum cases requiring intravenous fluid treatment for disease (n = 926) and controls with normal or no nausea and vomiting of pregnancy (n = 660), from the USA.Methods: Whole exome-wide sequencing and genome informatics were performed using the standard Regeneron pipeline. All variants were compared between cases and controls using dominant, recessive, and allelic models to identify variants with exome-wide significant p values (p < 10 −6 ). Odds ratios and associated p values were calculated for exome-wide significant allele(s) in subgroups of genetically predicted ancestries. Variants were filtered to identify rare pathogenic variants occurring in ≥10 cases and in no controls.Main outcome measures: Identification of exome-wide significant and rare genetic variant(s) associated with HG.Results: A common coding variant in GDF15 was the only exome-wide significant association, and a rare coding variant in GDF15 was the only predicted diseasecausing variant occurring in 10 or more cases. Conclusions:This study confirms the GWAS finding that GDF15 is the greatest genetic risk factor for HG. The new variants identified may have implications for prediction and diagnosis. The findings provide insight into the cause, and molecular mechanisms for developing therapeutics for HG.

show abstract

Section: Discussionmentioning

confidence: 99%