The height of cell-adhesive nanoposts generated by block copolymer/surfactant complex systems influences the preosteoblast phenotype

Jeong, Eun Ju; Lee, Jin Wook; Kwark, Young Je; Kim, Seung Hyun; Lee, Kuen Yong

doi:10.1016/j.colsurfb.2014.10.006

Cited by 5 publications

(6 citation statements)

References 41 publications

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“…Polystyrene-block-poly(ethylene oxide)/dodecylbenzenesulfonic acid (PS-b-PEO/DBSA) 3.4. [112] Pancreatic tumor cells, PaTu 8988t PAAm/bisAAm-b-PAA 3.4. [101] Endothelial cells (ECs) Polystyrene-block-poly(ethylene-co-butylene)-blockpolystyrene (SEBS) 3.4.…”

Section: Horseradish Peroxidase (Hrp)mentioning

confidence: 99%

“…For example, BCP nanotemplates were generated to provide periodic surface sites of ~8 nm in size to match the diameter of integrin in the cell membrane [106]. Nanoscopic topological features were also varied to control the spacing and density of biorecognition molecules for cell receptors which led to substantial changes in cell behaviors [105,106,112]. In one study, a BCP of PS-b-PI with ring-like FN nanopatterns was shown to increase the percent surface coverage and density of Chinese hamster ovary (CHO) cells relative to control substrates [92].…”

Section: Cell Adhesive Moleculesmentioning

confidence: 99%

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Self-Assembled Block Copolymers as a Facile Pathway to Create Functional Nanobiosensor and Nanobiomaterial Surfaces

Sytu,

Cho,

Hahm

2024

Polymers

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Block copolymer (BCP) surfaces permit an exquisite level of nanoscale control in biomolecular assemblies solely based on self-assembly. Owing to this, BCP-based biomolecular assembly represents a much-needed, new paradigm for creating nanobiosensors and nanobiomaterials without the need for costly and time-consuming fabrication steps. Research endeavors in the BCP nanobiotechnology field have led to stimulating results that can promote our current understanding of biomolecular interactions at a solid interface to the never-explored size regimes comparable to individual biomolecules. Encouraging research outcomes have also been reported for the stability and activity of biomolecules bound on BCP thin film surfaces. A wide range of single and multicomponent biomolecules and BCP systems has been assessed to substantiate the potential utility in practical applications as next-generation nanobiosensors, nanobiodevices, and biomaterials. To this end, this Review highlights pioneering research efforts made in the BCP nanobiotechnology area. The discussions will be focused on those works particularly pertaining to nanoscale surface assembly of functional biomolecules, biomolecular interaction properties unique to nanoscale polymer interfaces, functionality of nanoscale surface-bound biomolecules, and specific examples in biosensing. Systems involving the incorporation of biomolecules as one of the blocks in BCPs, i.e., DNA–BCP hybrids, protein–BCP conjugates, and isolated BCP micelles of bioligand carriers used in drug delivery, are outside of the scope of this Review. Looking ahead, there awaits plenty of exciting research opportunities to advance the research field of BCP nanobiotechnology by capitalizing on the fundamental groundwork laid so far for the biomolecular interactions on BCP surfaces. In order to better guide the path forward, key fundamental questions yet to be addressed by the field are identified. In addition, future research directions of BCP nanobiotechnology are contemplated in the concluding section of this Review.

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Section: Horseradish Peroxidase (Hrp)mentioning

confidence: 99%

Section: Cell Adhesive Moleculesmentioning

confidence: 99%

Self-Assembled Block Copolymers as a Facile Pathway to Create Functional Nanobiosensor and Nanobiomaterial Surfaces

Sytu,

Cho,

Hahm

2024

Polymers

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“…Lee et al designed a series of polymer surface nano-structures such as nanospots or nanodomains by the corporative self-assembly of PS-b-PEO with ionic surfactant dodecylbenzenesulfonic acid. [121,122] The surfactant was used to control the microphase separation behavior of the copolymer on substrate, resulting in the changes in the PS domain sizes. These regulations on the copolymer surface patterns greatly influence the cell adhesion, proliferation, and differentiation of the osteoblastic cells planted on the substrate.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Cooperative organizations of small molecular surfactants and amphiphilic block copolymers: Roles of surfactants in the formation of binary co‐assemblies

Cao

Yang

et al. 2021

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The construction of highly ordered organizations through self-assembly is one of the most popular phenomena both in natural and artificial environments. Amphiphilic molecules are the most commonly used building blocks for the self-assembly, which are conventionally known as amphiphilic low molecular weight surfactants with polar heads and nonpolar tails, or amphiphilic block copolymers (BCPs) consisting of covalently bonded hydrophilic and hydrophobic block chains. Compared with single surfactant self-assembly system, binary amphiphiles co-assembly systems composing of both small mass surfactants and amphiphilic BCPs feature high flexibilities and versatilities in materials designing and structure regulation, ascribing to the vast possibilities of intermolecular interactions within the systems and facile component modulations during the assembly processes. The amphiphilic features of the two kinds of molecules endow them with similar self-assembly behaviors, while the unique and distinct characters of each kind of amphiphiles lead to various complex but highly diversified co-assembly systems. According to the roles of the surfactant played in the co-assembly system, in this review, we summarize the binary coassembly systems from three distinct types: 1) the co-micellization system in which the surfactants are added into the BCPs assemblies as a self-assembly assistant; 2) the co-emulsification system in which the surfactants work as an emulsion stabilizer to assist and confine the assembly of BCPs in 3D geometries; 3) the co-templating system where the individual micelles of both surfactant and BCPs are hierarchically arranged and distributed to guide the formation of hierarchical nanomaterials. Following this, the major potential applications of the nanomaterials synthesized from the binary amphiphiles in biological field are described. Finally, we shortly discuss the current challenges and future perspectives of the binary amphiphiles selfassembly systems.

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“…21 On the other hand, BCP self-assembly has also been explored to develop cytocompatible nanopatterns with osteogenic properties. [22][23][24][25] These previous studies are very promising, but the used substrates (silicon wafers or glass) [26][27][28] are not appropriate for biomedical applications. Change of the substrate implies different interactions between BCP and the material surface, which can alter the nanocoating structure.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial nanopatterned coatings for dental implants

et al. 2022

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The height of cell-adhesive nanoposts generated by block copolymer/surfactant complex systems influences the preosteoblast phenotype

Cited by 5 publications

References 41 publications

Self-Assembled Block Copolymers as a Facile Pathway to Create Functional Nanobiosensor and Nanobiomaterial Surfaces

Self-Assembled Block Copolymers as a Facile Pathway to Create Functional Nanobiosensor and Nanobiomaterial Surfaces

Cooperative organizations of small molecular surfactants and amphiphilic block copolymers: Roles of surfactants in the formation of binary co‐assemblies

Antibacterial nanopatterned coatings for dental implants

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