The Heightened Risk of Fatty Liver Disorders in the Time of COVID-19

Stanfield, Dylan; Lucey, Michael R.

doi:10.1016/j.mayocp.2020.10.020

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…The growing incidence of obesity and NAFLD, in fact, is related to changes in food habits and sedentary lifestyles, especially during the SARS-CoV-2 pandemic [10].…”

Section: Epidemiologymentioning

confidence: 99%

Metabolic Dysfunction–Associated Fatty Liver Disease (MAFLD) and Thyroid Function in Childhood Obesity: A Vicious Circle?

Calcaterra,

Degrassi,

Taranto

et al. 2024

Children

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Metabolic dysfunction–associated fatty liver disease (MAFLD) is a multisystem disorder characterized by the presence of fatty liver degeneration associated with excess adiposity or prediabetes/type 2 diabetes or metabolic dysregulation. An intricate relationship between the liver and thyroid has been reported in both health and disease. Simultaneously, there is a strong correlation between obesity and both MAFLD and thyroid dysfunction. In this narrative review, we highlighted the relationship between MAFLD and thyroid function in children and adolescents with obesity in order to explore how thyroid hormones (THs) act as predisposing factors in the onset, progression, and sustainability of MAFLD. THs are integral to the intricate balance of metabolic activities, ensuring energy homeostasis, and are indispensable for growth and development. Regarding liver homeostasis, THs have been suggested to interact with liver lipid homeostasis through a series of processes, including stimulating the entry of free fatty acids into the liver for esterification into triglycerides and increasing mitochondrial β-oxidation of fatty acids to impact hepatic lipid accumulation. The literature supports a correlation between MAFLD and obesity, THs and obesity, and MAFLD and THs; however, results in the pediatric population are very limited. Even though the underlying pathogenic mechanism involved in the relationship between MAFLD and thyroid function remains not fully elucidated, the role of THs as predisposing factors of MAFLD could be postulated. A potential vicious circle among these three conditions cannot be excluded. Identifying novel elements that may contribute to MAFLD could offer a practical approach to assessing children at risk of developing the condition.

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“…The growing incidence of obesity and NAFLD, in fact, is related to changes in food habits and sedentary lifestyles, especially during the SARS-CoV-2 pandemic [10].…”

Section: Epidemiologymentioning

confidence: 99%

Metabolic Dysfunction–Associated Fatty Liver Disease (MAFLD) and Thyroid Function in Childhood Obesity: A Vicious Circle?

Calcaterra,

Degrassi,

Taranto

et al. 2024

Children

View full text Add to dashboard Cite

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“…Вынужденный локдаун и связанные с ним потери доходов и ухудшение социально-экономического статуса также способствовали нездоровому образу жизни и, связанному с ним ожирению и усугублению течения НАЖБП [15]. Таким образом, COVID-19 явился ещё и косвенной причиной распространения эпидемии НАЖБП [16].…”

Section: неалкогольная жировая болезнь печени и Covid-19unclassified

A new challenge for the liver in the 21st century

Ахмедов

2023

jour

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Recently accumulating evidence suggests that if patients have existing diffuse liver disease, the risk of developing serious complications both for the liver itself and for the course of COVID-19 increases significantly. The presented article provides information on the impact of the COVID-19 pandemic on the social aspects of human life, changes in the daily routine, which has a particularly unfavorable course on non-alcoholic fatty liver disease. In turn, a relationship has been found between progressive liver fibrosis in NAFLD patients and the severe course of COVID-19. It is noted that in patients with alcoholic liver disease the incidence of which increases with self-isolation, cases of severe bilateral pneumonia and acute respiratory distress syndrome with unfavorable outcomes, including cardiopulmonary and multiple organ failure, have been described. It is shown that patients with cirrhosis of the liver, especially those with decompensated form, are the most vulnerable group of patients, since immune dysfunction makes them prone to any type of infection, including COVID-19, with potentially serious consequences. It was noted that the risk of detecting liver cancer at later stages increased in about 25% of patients with a biologically aggressive type of disease against the background of the COVID-19 pandemic.

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“…All rights reserved Effects of the COVID-19 pandemic unrelated to SARS-CoV-2 infection itself may prove to have the biggest effect on ALD patients. Undoubtedly COVID-19 will enact massive collateral damage via the effects of deferred care, medication non-adherence, increased consumption of food and more high-risk alcohol use (27,28). The pathophysiology of ALD is complex but overall alcohol dose and pattern of consumption are both strongly implicated in the risk of ALD (29).…”

Section: Accepted Articlementioning

confidence: 99%

“…Undoubtedly, COVID-19 will enact massive collateral damage through the effects of deferred care, medication nonadherence, increased consumption of food, and more high-risk alcohol use. (27,28) The pathophysiology of ALD is complex but overall alcohol dose and pattern of consumption are both strongly implicated in the risk of ALD. (29) Increased alcohol consumption during the COVID-19 pandemic therefore has the potential to lead to increased morbidity and mortality.…”

Section: Outcomes Of Patients With Ald With Covid-19mentioning

confidence: 99%

Alcohol‐Associated Liver Disease Before and After COVID‐19—An Overview and Call for Ongoing Investigation

et al. 2021

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The Coronavirus Disease-2019 (COVID-19) pandemic has exacted a heavy toll on patients with alcohol-associated liver disease (ALD) and alcohol use disorder (AUD). The collective burden of ALD and AUD was large and growing prior to the COVID-19 pandemic. There is accumulating evidence that this pandemic has had a large direct effect on these patients and is likely to produce indirect effects via delays in care, psychological strain, and increased alcohol use. Now a year into the pandemic, it is important that clinicians fully understand the effects of the COVID-19 pandemic on patients with ALD and AUD. To fill existing gaps in knowledge, the scientific community must set research priorities for patients with ALD regarding their risk of COVID-19, prevention/treatment of COVID-19, changes in alcohol use during the pandemic, best use of AUD treatments in the COVID-19 era, and downstream effects of this pandemic on ALD. Conclusion: The COVID-19 pandemic has already inflicted disproportionate harms on patients with ALD and ongoing, focused research efforts will be critical to better understand the direct and collateral effects of this pandemic on ALD.

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The Heightened Risk of Fatty Liver Disorders in the Time of COVID-19

Cited by 5 publications

References 9 publications

Metabolic Dysfunction–Associated Fatty Liver Disease (MAFLD) and Thyroid Function in Childhood Obesity: A Vicious Circle?

Metabolic Dysfunction–Associated Fatty Liver Disease (MAFLD) and Thyroid Function in Childhood Obesity: A Vicious Circle?

A new challenge for the liver in the 21st century

Alcohol‐Associated Liver Disease Before and After COVID‐19—An Overview and Call for Ongoing Investigation

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