The hematologic effects of BTEX exposure among elderly residents in Nanjing: a cross-sectional study

Chen, Qi; Sun, Hong; Zhang, Jiayao; Xu, Yongjian; Zhang, Ding

doi:10.1007/s11356-019-04492-9

Cited by 29 publications

(31 citation statements)

References 35 publications

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Section: Discussionsupporting

confidence: 91%

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Zhang¹,

Deng²,

et al. 2020

Preprint

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Background: Ubiquitously distributed benzene is a known hematotoxin. Increasing evidence has suggested that erythroid-related hematologic parameters may be sensitive to benzene exposure. Fat content, which is also closely associated with erythroid-related hematologic parameters, may affect the distribution and/or metabolism of benzene, and eventually benzene-induced toxicity. Methods: To explore the influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters, we recruited 1669 petrochemical workers and measured their urinary S-phenylmercapturic acid (SPMA) concentration and erythroid-related hematological parameters. Indices for fat content included body fat percentage (BF%), plasma total cholesterol (TC) and triglycerides (TG) , and occurrence of fatty liver. Results: The dose-response curve revealed U-shaped nonlinear relationships of SPMA with hematocrit (HCT) and mean corpuscular hemoglobin concentration (MCHC) ( P -overall <0.001, and P -nonlinear < 0.015), as well as positive linear associations and r-shaped nonlinear relationships of continuous fat content indices with erythroid-related hematological parameters ( P -overall ≤ 0.005). We also observed modification effects of fat content on the associations between benzene exposure and erythroid-related hematological parameters, with workers of lower or higher BF% and TG more sensitive to benzene-induced elevation of MCHC ( P interaction =0.021) and benzene-induced decrease of HCT ( P interaction = 0.050), respectively. We also found that some erythroid-related hematologic parameters differed between subgroups of workers with different SPMA levels and fat content combination. Conclusions: Our study suggested that benzene exposure, fat content, and their interactions may affect erythroid-related hematological parameters in petrochemical workers in a complex manner that are worthy of further investigation.

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Section: Discussionsupporting

confidence: 91%

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Zhang¹,

Deng²,

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Our findings suggested that the relationship between benzene exposure and erythroid-related hematologic parameters may be discrepant at different exposure levels. MCHC was found to be inversely associated with blood benzene in residents living near petrochemical areas at environmental exposure concentration [24], which was consistent with our finding that at lower benzene exposure level, MCHC decreased with the increase of SPMA. Furthermore, significant decreased HCT and increased MCHC were observed in individuals working in high traffic and industrial areas with high concentration of benzene [25], which was also consistent with our finding that at higher benzene exposure level, MCHC increased and HCT decreased with the increase of SPMA.…”

Section: Discussionsupporting

confidence: 91%

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Xiao¹,

Zhang²,

Deng³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Ubiquitously distributed benzene is a known hematotoxin. Increasing evidence has suggested that erythroid-related hematologic parameters may be more sensitive to benzene exposure. Fat content, which is also closely associated with erythroid-related hematologic parameters, may affect the distribution and/or metabolism of benzene, and eventually benzene-induced toxicity. Methods: To explore the influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters, we recruited 1669 petrochemical workers and detected their urinary S-phenylmercapturic acid (SPMA) concentration and erythroid-related hematological parameters. Indices for fat content included body fat percentage (BF%), plasma total cholesterol (TC) and triglyceride (TG) , and occurrence of fatty liver. Results: The dose-response curve revealed U-shaped nonlinear relationships of SPMA with hematocrit (HCT) and mean corpuscular hemoglobin concentration (MCHC) ( P -overall <0.001, and P -nonlinear < 0.015), as well as positive linear associations and r-shaped nonlinear relationships of continuous fat content indices with erythroid-related hematological parameters ( P -overall ≤ 0.005). We also observed modification effects of fat content on the associations between benzene exposure and erythroid-related hematological parameters, with workers of lower or higher BF% more sensitive to benzene-induced elevation of MCHC ( P interaction =0.021), while workers of lower or higher TG more sensitive to benzene-induced decrease of HCT ( P interaction = 0.050). We also found that some erythroid-related hematologic parameters were different in categories with different SPMA level and fat content. Conclusions: Our study suggested that benzene exposure, fat content, and their interactions may affect erythroid-related hematological parameters in petrochemical workers in a complex manner that are worthy of further investigation.

show abstract

“…This suggests that the relationship between benzene exposure and some erythroid-related hematologic parameters may be discrepant at different exposure levels. MCHC was found to be inversely associated with blood benzene in residents living near petrochemical areas at environmental exposure concentration [25], which was consistent with our finding that at lower benzene exposure levels, MCHC decreased with increasing SPMA. Furthermore, significantly decreased HCT and increased MCHC were observed in individuals working in high traffic and industrial areas with high concentration of benzene [26], which was also consistent with our finding that at higher benzene exposure levels, MCHC increased and HCT decreased with increasing SPMA.…”

Section: Discussionsupporting

confidence: 91%

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Zhang

Deng

et al. 2020

BMC Public Health

View full text Add to dashboard Cite

Background: Ubiquitously distributed benzene is a known hematotoxin. Increasing evidence has suggested that erythroid-related hematologic parameters may be sensitive to benzene exposure. Fat content, which is also closely associated with erythroid-related hematologic parameters, may affect the distribution and/or metabolism of benzene, and eventually benzene-induced toxicity. Methods: To explore the influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters, we recruited 1669 petrochemical workers and measured their urinary S-phenylmercapturic acid (SPMA) concentration and erythroid-related hematological parameters. Indices for fat content included body fat percentage (BF%), plasma total cholesterol (TC) and triglycerides (TG), and occurrence of fatty liver. Results: The dose-response curve revealed U-shaped nonlinear relationships of SPMA with hematocrit (HCT) and mean corpuscular hemoglobin concentration (MCHC) (P-overall < 0.001, and P-nonlinear < 0.015), as well as positive linear associations and r-shaped nonlinear relationships of continuous fat content indices with erythroid-related hematological parameters (P-overall ≤0.005). We also observed modification effects of fat content on the associations between benzene exposure and erythroid-related hematological parameters, with workers of lower or higher BF% and TG more sensitive to benzene-induced elevation of MCHC (P interaction = 0.021) and benzene-induced decrease of HCT (P interaction = 0.050), respectively. We also found that some erythroid-related hematologic parameters differed between subgroups of workers with different SPMA levels and fat content combination.

show abstract

The hematologic effects of BTEX exposure among elderly residents in Nanjing: a cross-sectional study

Cited by 29 publications

References 35 publications

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

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