The Hemodynamic and Respiratory Effects of Diazepam (Valium®)

Evaluation of Premedicants as Protective Agents Against Convulsive (LD50) Doses of Local Anesthetic Agents in Rats

“…22 This may in fact be the prevailing effect; however, to elaborate on the depressive effect of the other drugs would be purely speculative, since cardiac and respiratory functions were not measured in these animal experiments.…”

Cardiovascular haemodynamics during enflurane-pancuronium anaesthesia in patients with valvular heart disease

“…If any lingering effect of the small amount of barbiturate used for induction should have influenced our results it should have been in the direction of a cardiovascular depression of direct as well as central sympathetic origin. 8 Diazepam was chosen for premeditation because of its potent sedative and minimal cardiovascular influence (Dalen, et al 1969). 9 Scopolamine was chosen for its lack of chronotropic effect (Gravenstein and Thornby 1969)/0 which makes it preferable to atropine when tachycardia should be avoided, as in patients with cardiac valvular disease where digitalis is discontinued at least 24 hours prior to surgery.…”

Diazepam sedation reduces functional residual capacity and alters the distribution of ventilation in man

“…Is-19 Regional lung variables were expressed as a linear function of vertical distance down the lung fields in the lateral position, 2~ using data taken from vertically adjacent topographical areas measuring 2 cm vertically and 8-10 cm horizontally and located mid-way between the apices and bases of the lung fields. Individual values of [9]r and [(~r were normalized to an index of 100, such that had ventilation and perfusion been uniform throughout the lungs, all regional indices would have been 100.…”