The Hemodynamic Effects of Cremophor-El

Bowers, Victor; Locker, Steven; Ames, Scott; Jennings, William; Corry, Robert J.

doi:10.1097/00007890-199104000-00021

Cited by 36 publications

(16 citation statements)

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“…It is known that Cremophor EL-P, the co-solvent of Tookad formulation for intravenous injection, can induce a marked blood pressure drop in canines, due to the anaphylactoid reaction in this species [36]. This side effect can be easily controlled by pre-medication with an antihistamine (Benadryl, 0.7-1.4 mg/kg IV) and steroids (Dexamethasone, 2 mg SQ) and the adjustment of IV fluid volume and anesthetic levels.…”

Section: Discussionmentioning

confidence: 99%

Studies of a vascular‐acting photosensitizer, Pd‐bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Studies of a vascular‐acting photosensitizer, Pd‐bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer

et al. 2005

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“…Some studies indicate that Cremophor®EL may trigger complement activation (14)(15)(16). In rats, Cremophor®EL may induce adverse haemodynamic effects (17). Because of these numerous side effects, Cremophor®EL-free formulations of paclitaxel have been developed and are expected to show less toxicity for patients during chemotherapy treatment.…”

Section: Introductionmentioning

confidence: 99%

Toxicological Study and Efficacy of Blank and Paclitaxel-Loaded Lipid Nanocapsules After i.v. Administration in Mice

et al. 2010

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“…It is known that Cremophor EL-P, the co-solvent of Tookad formulation for intravenous injection, can induce a marked blood pressure drop in the dogs, due to the anaphylactoid reaction in this species (33). This side effect can be easily controlled by pre-medication with anti-histamine (i.v.…”

Section: Discussionmentioning

confidence: 99%

Studies of a novel photosensitizer palladium-bacteriopheophorbide (Tookad) for the treatment of prostate cancer

et al. 2003

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In this study, photodynamic therapy (PDT) mediated with a novel, second generation photosensitizer Tookad ® (palladium-bacteriopheophorbide, WST09, STEBA Biotech, France), is investigated as an alternative modality in the treatment of prostate cancer. In vivo normal canine prostate and spontaneous advanced prostate cancer are used as the animal model. PDT was performed by irradiating the surgically exposed prostates with a diode laser (763 nm, 150 mW /cm) to activate the i.v. infused photosensitizer. The effects of drug concentration, drug-light interval, and light fluence rate on the PDT efficacy were studied. The prostates and adjacent tissues (bladder and underlying colon) were harvested and subjected to histopathological examination. During the one-week to 3-month period post PDT treatment, the dogs recovered well with little or no urethral complications. Prostatic urethra and prostate adjacent tissues (bladder and underlying colon) were well preserved. Light irradiation delivered during drug infusion or within 15 min post drug infusion induced the similar extend of damages. PDT induced prostate lesions in both normal and cancerous prostate were characterized by marked hemorrhagic necrosis and atrophy. Maximum lesion size of over 3 cm in dimension could be achieved with a single 1-cm interstitial treatment, suggesting the therapy is very effective in ablating cancerous prostatic tissue. In conclusion, the second generation photosensitizer Tookad ® mediated PDT may provide an effective alternative to treat prostate cancer.

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The Hemodynamic Effects of Cremophor-El

Cited by 36 publications

References 0 publications

Studies of a vascular‐acting photosensitizer, Pd‐bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer

Studies of a vascular‐acting photosensitizer, Pd‐bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer

Toxicological Study and Efficacy of Blank and Paclitaxel-Loaded Lipid Nanocapsules After i.v. Administration in Mice

Studies of a novel photosensitizer palladium-bacteriopheophorbide (Tookad) for the treatment of prostate cancer

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