The hemostatic efficacy of chitosan-pads in hemodialysis patients with significant bleeding tendency

Misgav, Mudi; Lubetszki, Ahron; Brutman‐Barazani, Tami; Martinowitz, Uri; Kenet, Gili

doi:10.5301/jva.5000707

Cited by 17 publications

(13 citation statements)

References 24 publications

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“…Hemostasis of dialysis access puncture wound bleeding after needle extraction is very important for HD patients. The common method of hemostasis of vascular access site of HD patients is using simple conventional gauze dressing and manual pressure [ 6 - 8 ]. Oxidized regenerated cellulose is one of the hemostatic agents that accelerate the coagulation cascade and clot formation.…”

Section: Discussionmentioning

confidence: 99%

“…The authors concluded that Chitosan-based pads could be effective in bleeding control in patients with coagulopathy. In the study by Misgav et al ., the hemostasis time was 3 min at the arterial access site in the Chitosan pad group compared to 18.5 min in the control group while this time was 2.8 min at the venous access site in the Chitosan group compared to 13.2 min in the control group [ 8 ]. This difference can be due to two reasons.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of HemoFoam® and Conventional Gauze Dressing on Hemostasis of Vascular Access Site in Hemodialysis Patients

Bizari

Khoshmohabat

Kordestani

et al. 2019

GMJ

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Background: Dialysis access puncture wound bleeding after needle extraction at the end of each hemodialysis session is a very important problem. This study evaluated the effect of HemoFoam® compared to conventional gauze dressing on hemostasis of dialysis access puncture wound bleeding in hemodialysis patients. Materials and Methods: This one-group, before-after, clinical-trial was conducted on 60 hemodialysis patients selected by convenience sampling who underwent hemodialysis through arteriovenous fistula in Shahid Rahnemoon Hospital, Yazd, Iran in 2017. After reviewing the eligibility criteria, the study was performed in two separate sessions. In the first session, only HemoFoam® was used while in the second session; the only conventional dressing was used. Time of hemostasis in each puncture wound was evaluated. Data were analyzed by SPSS 22 (IBM SPSS Statistics for Windows, Armonk, NY: IBM Corp, United States) using paired T-test and Chi-square tests. Results: The mean age of the patients was 55.20±14.25 years. Hemostasis was achieved in 76.6% of cases at the arterial access site in the first two minutes in the HemoFoam® group. The mean homeostasis time in the HemoFoam® group was 2.86±1.87 min at the venous access site and 3.15±1.97 min at the arterial access site (P<0.001). The mean homeostasis time in the conventional dressing group was 10.54±6.65 min at venous access site and 12.74±9.28 min at the arterial access site, which was significantly different between the two groups (P<0.001). Conclusion: HemoFoam® is effective in reducing the time of homeostasis in the vascular access site of hemodialysis patients. Therefore, its use in hemodialysis wards is recommended for hemostasis in the dialysis access puncture wound bleeding. [GMJ.2019;8:e1395]

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of HemoFoam® and Conventional Gauze Dressing on Hemostasis of Vascular Access Site in Hemodialysis Patients

Bizari

Khoshmohabat

Kordestani

et al. 2019

GMJ

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“…It can be used as a carrier for brain drug delivery and for various ocular therapeutic molecules such as drugs, genes and proteins in ophthalmology that deal with visual system diseases. Another medical application involves its use in renal failure and hemodialysis [46]. Chitosan is widely used as a carrier in delivering active agents and drugs [47], in gene and cancer therapy [48], in biosensor monitoring and bio imaging [49,50].…”

Section: Chitosan In Biomedical Applicationsmentioning

confidence: 99%

Chitosan-Based (Nano)Materials for Novel Biomedical Applications

et al. 2019

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Chitosan-based nanomaterials have attracted significant attention in the biomedical field because of their unique biodegradable, biocompatible, non-toxic, and antimicrobial nature. Multiple perspectives of the proposed antibacterial effect and mode of action of chitosan-based nanomaterials are reviewed. Chitosan is presented as an ideal biomaterial for antimicrobial wound dressings that can either be fabricated alone in its native form or upgraded and incorporated with antibiotics, metallic antimicrobial particles, natural compounds and extracts in order to increase the antimicrobial effect. Since chitosan and its derivatives can enhance drug permeability across the blood-brain barrier, they can be also used as effective brain drug delivery carriers. Some of the recent chitosan formulations for brain uptake of various drugs are presented. The use of chitosan and its derivatives in other biomedical applications is also briefly discussed.

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“…В качестве материалов для экспериментальных исследований были использованы образцы гемостатических коллагеновых губок с длиной, шириной и высотой материала 1 см, взвешенные на торсионных весах, содержащие: гемоблок 2%; гемоблок 5% [5]; гемоблок и транексамовую кислоту; тромбоциты и транексамовую кислоту [6,7]; криопреципитат 10%; криопреципитат и транексамовую кислоту; хитозан и капрофен [8,9]; транексамовую кислоту 9%. В качестве сравнительных образцов были использованы гемостатические коллагеновые губки Белкозин и Зеленая Дубрава.…”

Section: материал и методыunclassified

Investigation of the properties of new collagen-based hemostatic sponges

Бежин¹,

Soldatova²,

Истранов³

et al. 2018

Oper. khir.

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Цель исследования. Изучить в сравнительном аспекте кровоостанавливающие свойства препаратов на основе коллагеновой губки и разработать методику оценки эффективности этих препаратов при остановке паренхиматозных кровотечений в хирургической практике. Материал и методы. Проведено изучение эффективности кровоостанавливающих свойств но вых пре па ратов на ос нове коллагеновой губки при остановке паренхиматозных кровотечений. Эксперименты in vivo вы пол не ны на 110 белых крысах линии Вистар обоего пола массой 180-200 г без внешних признаков заболеваний. Все манипуляции с животными проводились с использованием общего обезболивания (ксилазина гидрохлорид, золетил), а выведение из экспериментовпутем передозировки средств для наркоза. После выполнения срединной лапаротомии производили поочередное отсечение края печени (длина раны по касательной к окружности доли печени составляла 1 см, глубина-0,5 см) и селезенки (длина-0,5 см, глубина-0,3 см) с остановкой кровотечения путем аппликации исследуемого материала (известной массы, 1×1×1 см). Полученные данные обработали с использованием методов операционной статистики. Достоверность различий оценивали путем вычисления доверительного интервала. Были введены новые количественные и качественные показатели. В качестве контроля была применена технология с использованием коллагеновых губок производства компаний ООО «Белкозин» и ЗАО «Зеленая Дубрава». Результаты. Вопреки ожидаемым результатам более эффективными оказались монокомпонентные губки (с транексамовой кислотой 9% и криопреципитатом 10%, затем следовала их комбинация, р<0,05). Также монопрепарат гемоблок 5% оказался эффективнее комбинации гемоблока и транексамовой кислоты, р<0,05. Заключение. По результатам работы cделан вывод: все представленные образцы обладают кровоостанавливающими свойствами, в большинстве своем превосходящими имеющиеся на рынке аналоги, и могут применяться при операциях на паренхиматозных органах, что значительно снизит число послеоперационных осложнений.

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The hemostatic efficacy of chitosan-pads in hemodialysis patients with significant bleeding tendency

Abstract: Chitosan pads significantly reduce time to hemostasis and should be considered for the treatment of accessible bleeds in patients with coagulopathy.

Cited by 17 publications

References 24 publications

Comparison of HemoFoam® and Conventional Gauze Dressing on Hemostasis of Vascular Access Site in Hemodialysis Patients

Comparison of HemoFoam® and Conventional Gauze Dressing on Hemostasis of Vascular Access Site in Hemodialysis Patients

Chitosan-Based (Nano)Materials for Novel Biomedical Applications

Investigation of the properties of new collagen-based hemostatic sponges

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