The hepatitis C virus genotype and subtype frequency in hepatitis C virus RNA‐positive, hepatitis C virus antibody‐negative blood donors identified in the nucleic acid test screening program in Poland

Brojer, Ewa; Gronowska, Agnieszka; Medyńska, Joanna; Grabarczyk, Piotr; Mikulska, Maria; Łętowska, Magdalena; Kryczka, Wiesław; Gietka, Andrzej

doi:10.1111/j.0041-1132.2004.04156.x

Cited by 13 publications

(21 citation statements)

References 32 publications

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“…A Siberian study reported that the risk factor for HCV infection was higher among patients who had at least four sexual partners during their lives history, homosexual behaviour, or a history of STD (35). All other potential risk factors reported by the patients (HCV RNA-positive heterosexual partner, two or more heterosexual partners, dental procedures, body piercing and tattooing) also appeared in a study carried out by Brojer et al (7) and Orton et al (30). The results confirm the advantage of interviewing rather than patients completing a routine questionnaire to identify risk factors.…”

Section: Discussionmentioning

confidence: 85%

Viral Hepatitis C in a leading Brazilian hospital: epidemiological factors and genotyping

Bezerra¹,

Lima²,

Vilar³

et al. 2007

Braz. J. Microbiol.

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The hepatitis C virus (HCV) is classified into six different genotypes and their distribution is different throughout the world. Epidemiologic studies are important to determine several characteristics of the virus, as well as the disease. This study analysed the prevalence of HCV and its genotypes among patients from a leading hospital in Ceará, which is located in Northeast Brazil. A total of 119 anti-HCV-seropositive patients, each having previously completed a questionnaire about risk behaviours related to HCV infection were tested for HCV infection using a qualitative HCV polymerase chain reaction (PCR) assay and genotyping by restriction fragment length polymorphism (RFLP). The detection was based on amplifying of the non-coding 5' region. Of the 119 patients, 95 showed positive results in the qualitative HCV test. History of surgery was the most reported risk factor, followed by the use of drugs, having tattoos, undergoing haemodialysis and occupational exposure. Genotype 1 was the most prevalent (46.9%), followed by genotype 3 (34.4%) and 2 (8.3%). The genotype distribution was similar for all of the various risk behaviours.

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Section: Discussionmentioning

confidence: 85%

Viral Hepatitis C in a leading Brazilian hospital: epidemiological factors and genotyping

Bezerra¹,

Lima²,

Vilar³

et al. 2007

Braz. J. Microbiol.

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“…However, other studies of pediatric populations in different parts of Poland did not confirm those findings [Wysocki et al, 1994;Woźniakowska-Gęsicka et al, 1997]. Interestingly, HCV genotype 4 was found in as many as 14% of 50 window-period (anti-HCV negative and HCV-RNA-positive) blood donors identified in a nucleic acid test screening program in Poland, compared to 1.4% with genotype 4 in the control group of anti-HCV seropositive blood donors [Brojer et al, 2004]. The differences in genotype distribution between the two groups could be attributed to the relative increase in frequency of genotype 4 in recently acquired (windowperiod) infections.…”

Section: Discussionmentioning

confidence: 94%

High prevalence of genotype 4 among hepatitis C virus‐infected intravenous drug users in North‐Eastern Poland

Chlabicz¹,

Flisiak²,

Kowalczuk³

et al. 2008

Journal of Medical Virology

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The aim of this study was to describe the distribution of hepatitis C genotypes among intravenous drug users in north-eastern Poland. The study group included intravenous drug users recruited at a drug treatment center and a clinic for HIV-infected patients. HCV infection was confirmed by qualitative nested RT-PCR to test for the presence of HCV RNA. Genotypes were determined by 5'UTR sequencing and comparing the results with known genotype sequences. Among 111 HCV-infected and HCV-RNA-positive intravenous drug users, the most prevalent genotypes were 1 (38.7%), 3 (37.8%), and 4 (23.4%). Most infections with genotype 4 (88.5%) were found among HCV-HIV-coinfected drug users. The study demonstrated a high prevalence of genotype 4 (23.4%) among HCV-infected Polish drug users.

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“…Among 70 anti‐HCV‐positive blood donors, 75.7% were genotype 1b, 4.3% genotype 1a, 14.3% genotype 3a, 4.3% genotype 4 and 1.4% genotype 6. Among 170 hepatitis patients, 85.3% were genotype 1b, 0.6% genotype 1a, 10.6% genotype 3a, 1.2% genotype 4 and 2.4% mixed (241).…”

Section: Resultsmentioning

confidence: 99%

A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel

Cornberg

Razavi

Alberti

et al. 2011

Liver International

373

294

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Background and Aim: Decisions on public health issues are dependent on reliable epidemiological data. A comprehensive review of the literature was used to gather country-specific data on risk factors, prevalence, number of diagnosed individuals and genotype distribution of the hepatitis C virus (HCV) infection in selected European countries, Canada and Israel. Methodology: Data references were identified through indexed journals and non-indexed sources. In this work, 13 000 articles were reviewed and 860 were selected based on their relevance. Results: Differences in prevalence were explained by local and regional variances in transmission routes or different public health measures. The lowest HCV prevalence ( 0.5%) estimates were from northern European countries and the highest (Z3%) were from Romania and rural areas in Greece, Italy and Russia. The main risk for HCV transmission in countries with wellestablished HCV screening programmes and lower HCV prevalence was injection drug use, which was associated with younger age at the time of infection and a higher infection rate among males. In other regions, contaminated glass syringes and Keywords diagnosis -epidemiology -HCV -hepatitis C -incidence -mortality -prevalence Conclusion: Despite the eradication of transmission by blood products, HCV infection continues to be one of the leading blood-borne infections in the region.Chronic hepatitis C (CHC) is a major health burden in Europe. Recent data suggest that patients with CHC have a higher overall morbidity and mortality (1, 2). A significant portion of liver transplantation in Europe is attributable to cirrhosis and hepatocellular carcinoma because of CHC (3). The socioeconomic impact of hepatitis C virus (HCV) infection is tremendous. The incidence of complications of CHC will not decline over the next 10 years despite improved efficacy of antiviral therapy because most patients with CHC remain undiagnosed (4). Prevention of new infections, HCV screening and early treatment have the potential to reduce the overall morbidity and mortality. However, the cost-effectiveness of HCV screening may depend on the HCV prevalence (5). Decisions on public health issues such as HCV screening and prevention measures are dependent on reliable epidemiological data regarding HCV prevalence and transmission routes. The epidemiological status in Europe is continuously evolving and may vary significantly among the different regions throughout Europe (6). Thus, different countries may need different strategies to reduce the overall burden of HCV infection.Because epidemiological data are the basis for the development of preventive measures, we aimed to systematically identify, review and characterize HCV epidemiology throughout Europe. We included Canada and Israel in our analysis because their healthcare systems and the epidemiological situation are similar to many European countries. MethodsA comprehensive review of the literature was used to gather country-specific data on risk factors, prevalence, number of diagnosed...

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The hepatitis C virus genotype and subtype frequency in hepatitis C virus RNA‐positive, hepatitis C virus antibody‐negative blood donors identified in the nucleic acid test screening program in Poland

Cited by 13 publications

References 32 publications

Viral Hepatitis C in a leading Brazilian hospital: epidemiological factors and genotyping

Viral Hepatitis C in a leading Brazilian hospital: epidemiological factors and genotyping

High prevalence of genotype 4 among hepatitis C virus‐infected intravenous drug users in North‐Eastern Poland

A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel

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