The Herb‐Drug Interaction of Clopidogrel and Xuesaitong Dispersible Tablet by Modulation of the Pharmacodynamics and Liver Carboxylesterase 1A Metabolism

Ma, Shengming; Dai, Guoliang; Bi, Xiaolin; Gong, Meirong; Miao, Chenggui; Chen, Hao; Gao, Liangliang; Zhao, Weiman; Liu, Tianjun; Zhang, Ningru

doi:10.1155/2018/5651989

Cited by 10 publications

(4 citation statements)

References 27 publications

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“…The observed early exogenous toxicity effects at the highest dose indicate the need for further study of a longer dosing duration. Recently, extensive studies have been carried out on other combined herbs to further understand undesirable effects such as any potential interaction (synergistic or antagonistic) with other substances, such as food and conventional drugs [ 80 , 81 ]. Therefore, a similar approach for this polyherbal formulation should also be implemented where its efficacy or any tendency to cause specific organ toxicity is explored.…”

Section: Discussionmentioning

confidence: 99%

Herbal-Based Formulation Containing Eurycoma longifolia and Labisia pumila Aqueous Extracts: Safe for Consumption?

et al. 2021

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A combined polyherbal formulation containing tongkat ali (Eurycoma longifolia) and kacip fatimah (Labisia pumila) aqueous extracts was evaluated for its safety aspect. A repeated dose 28-day toxicity study using Wistar rats was conducted where the polyherbal formulation was administered at doses 125, 500 and 2000 mg/kg body weight to male and female treatment groups daily via oral gavage, with rats receiving only water as the control group. In-life parameters measured include monitoring of food and water consumption and clinical and functional observations. On day 29, blood was collected for haematological and biochemical analysis. The rats were necropsied and the organs were collected for histopathological examination. This study showed that the combined formulation did not induce any significant toxicity effect at any dose level in terms of morbidity, mortality, behaviour, functional observation, body weight, food and water consumption, whole blood haematology and serum biochemistry. However, there were some microscopic changes in the histopathological examinations of some organs given 2000 mg/kg body weight, which may suggest an early response to the polyherbal formulation. From this study, the no observed adverse effect level is estimated to be more than 500 mg/kg body weight but not exceeding 2000 mg/kg body weight. The observed effects at the highest dose indicate the need for further study of longer dosing duration.

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Section: Discussionmentioning

confidence: 99%

Herbal-Based Formulation Containing Eurycoma longifolia and Labisia pumila Aqueous Extracts: Safe for Consumption?

et al. 2021

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“…One major limitation of these systems is the inability to detect any effects from chronic exposure to the given natural products, which is a common practice in real life. Although we did not include any results of animal studies in this review, we are aware of the modulatory effects of one or more natural constituents from danshen and ginseng products on CES1 expression (i.e., downregulation) in Sprague-Dawley rat livers (Ma et al, 2018;Ji et al, 2019). Existence of such a mechanism may either intensify or counteract the chemical interaction with CES1, highlighting the need of more-thorough research.…”

Section: Discussionmentioning

confidence: 99%

Natural Products as Modulators of CES1 Activity

Qian

Markowitz

2020

Drug Metab Dispos

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Carboxylesterase (CES) 1 is the predominant esterase expressed in the human liver and is capable of catalyzing the hydrolysis of a wide range of therapeutic agents, toxins, and endogenous compounds. Accumulating studies have demonstrated associations between the expression and activity of CES1 and the pharmacokinetics and/or pharmacodynamics of CES1 substrate medications (e.g., methylphenidate, clopidogrel, oseltamivir). Therefore, any perturbation of CES1 by coingested xenobiotics could potentially compromise treatment. Natural products are known to alter drug disposition by modulating cytochrome P450 and UDP-glucuronosyltransferase enzymes, but this issue is less thoroughly explored with CES1. We report the results of a systematic literature search and discuss natural products as potential modulators of CES1 activity. The majority of research reports reviewed were in vitro investigations that require further confirmation through clinical study. Cannabis products (D 9 -tetrahydrocannabinol, cannabidiol, cannabinol); supplements from various plant sources containing naringenin, quercetin, luteolin, oleanolic acid, and asiatic acid; and certain traditional medicines (danshen and zhizhuwan) appear to pose the highest inhibition potential. In addition, ursolic acid, gambogic acid, and glycyrrhetic acid, if delivered intravenously, may attain high enough systemic concentrations to significantly inhibit CES1. The provision of a translational interpretation of in vitro assessments of natural product actions and interactions is limited by the dearth of basic pharmacokinetic data of the natural compounds exhibiting potent in vitro influences on CES1 activity. This is a major impediment to assigning even potential clinical significance. The modulatory effects on CES1 expression after chronic exposure to natural products warrants further investigation. SIGNIFICANCE STATEMENTModulation of CES1 activity by natural products may alter the course of treatment and clinical outcome. In this review, we have summarized the natural products that can potentially interact with CES1 substrate medications. We have also noted the limitations of existing reports and outlined challenges and future directions in this field.

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“…After anesthetizing the mice in each group, the mouse uterus was taken, and the total protein was extracted according to the instructions using enhanced BCA protein assay kit (Beyotime, P0010), and the protein concentration was determined. Referring to the detailed description of the western blot protocol [ 28 ], an equal amount (50 μg) of protein isolated from mouse uterine tissue was separated on an SDS-PAGE gel, and then the protein was transferred to a PVDF membrane. The primary antibody is diluted according to the instructions, including Anti-NF-kB p65 antibody, Anti-NF-kB p65 (phospho S536) antibody, Anti-IL-1 beta antibody, Anti-IL-6 antibody, Anti-TNF alpha antibody, Anti-MMP2 antibody, Anti-MMP9 antibody, Anti-STAT3 antibody, recombinant Anti -STAT3 (phospho Y705) antibody, Anti-IRS1 antibody, Anti-IRS1 (phospho S307) antibody, Anti-PI 3 Kinase p85 alpha antibody, Anti -PI3Kinase p85 alpha (phospho Y607) antibody, and GAPDH.…”

Section: Methodsmentioning

confidence: 99%

Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice

Hong

et al. 2020

Chin Med

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Background It is showed that inflammation is causative factor for PCOS, leading to a decline in ovarian fertility. Previous studies have reported that tea consumption can reduce the incidence of ovarian cancer. We speculate that catechins from oolong tea (Camellia sinensis (L.) O. Kuntze) may have a potential therapeutic effect on PCOS. This study aims to investigate the effects of oolong tea catechins on the uterus of polycystic ovary syndrome (PCOS) mice induced by insulin combined with human chorionic gonadotropin (hCG). Methods Sixty female mice were divided into 6 groups (n = 10): model, model + Metformin 200 mg/kg, model + catechins 25 mg/kg, model + catechins 50 mg/kg, and model + catechins 100 mg/kg. Another forty female mice were divided into 4 groups (n = 10): control, control + catechins 100 mg/kg, model, and model + catechins 100 mg/kg. Ovarian and uterine weight coefficients, sex hormone levels, glucose metabolism and insulin resistance, and ovarian and uterine pathology were examined. Changes in NF-κB-mediated inflammation, MMP2 and MMP9 expressions, and STAT3 signaling were evaluated in the uterus of mice. Results Catechins could effectively reduce the ovarian and uterine organ coefficients, reduce the levels of E2, FSH and LH in the blood and the ratio of LH/FSH, and improve glucose metabolism and insulin resistance in PCOS mice induced by insulin combined with hCG. In addition, catechins could significantly down-regulated the expression of p-NF-κB p65 in the uterus and the protein expressions of the pro-inflammatory factors (IL-1β, IL-6, and TNF-α). The expressions of mmp2 and mmp9 associated with matrix degradation in uterine tissue were also significantly down-regulated by catechins. Further, catechins significantly reduced the expression of p-STAT3 and increased the expression of p-IRS1 and p-PI3K in the uterus of PCOS mice. Conclusion Catechins from oolong tea can alleviate ovarian dysfunction and insulin resistance in PCOS mice by inhibiting uterine inflammation and matrix degradation via inhibiting p-STAT3 signaling.

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The Herb‐Drug Interaction of Clopidogrel and Xuesaitong Dispersible Tablet by Modulation of the Pharmacodynamics and Liver Carboxylesterase 1A Metabolism

Cited by 10 publications

References 27 publications

Herbal-Based Formulation Containing Eurycoma longifolia and Labisia pumila Aqueous Extracts: Safe for Consumption?

Herbal-Based Formulation Containing Eurycoma longifolia and Labisia pumila Aqueous Extracts: Safe for Consumption?

Natural Products as Modulators of CES1 Activity

Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice

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