The herbal drug Catuama reverts and prevents ventricular fibrillation in the isolated rabbit heart

Pontieri, Vera; Neto, Augusto Scalabrini; Camargo, André Ferrari de França; Koike, Márcia Kiyomi; Velasco, Irineu Tadeu

doi:10.1016/j.jelectrocard.2007.06.002

Cited by 10 publications

(8 citation statements)

References 23 publications

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“…aphrodisiaca ) along with guarana seed extract have been shown to be useful in modulating physiological processes which influence gut motility, food intake and energy balance. Guarana extract can also prevent ventricular fibrillation 43. These studies demonstrate the multipronged role played by guarana seed extract in cell metabolism 38–41…”

Section: Introductionmentioning

confidence: 81%

A Novel Dietary Supplement Containing Multiple Phytochemicals and Vitamins Elevates Hepatorenal and Cardiac Antioxidant Enzymes in the Absence of Significant Serum Chemistry and Genomic Changes

Bulku

Zinkovsky

Patel

et al. 2010

Oxidative Medicine and Cellular Longevity

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A novel dietary supplement composed of three well-known phytochemicals, namely, Salvia officinalis (sage) extract, Camellia sinensis (oolong tea) extract, and Paullinia cupana (guarana) extract, and two prominent vitamins (thiamine and niacin) was designed to provide nutritional support by enhancing metabolism and maintaining healthy weight and energy. The present study evaluated the safety of this dietary supplement (STG; S, sage; T, tea; G, guarana) and assessed changes in target organ antioxidant enzymes (liver, kidneys and heart), serum chemistry profiles and organ histopathology in Fisher 344 rats. Adult male and female Fisher 344 rats were fed control (no STG) or STG containing (1X and 7X, 1X = daily human dose) diets and sacrificed after 2 and 4 months. Serum chemistry analysis and histopathological examination of three vital target organs disclosed no adverse influence on protein, lipid and carbohydrate profiles, genomic integrity of the liver and/or the tissue architecture. However, analysis of the most important antioxidant components in the liver, kidney and heart homogenates revealed a dramatic increase in total glutathione concentrations, glutathione peroxidase and superoxide dismutase enzyme activities. Concomitantly, oxidative stress levels (malondialdehyde accumulation) in these three organs were less than control. Organ specific serum markers (ALT/AST for the liver; CPK/AST/LDH for the heart; BUN/creatinine for kidneys) and the genomic integrity disclosed no STG-induced alteration. Some of the serum components (lipid and protein) showed insignificant changes. Overall, STG-exposed rats were more active, and the results suggest that STG exposure produces normal serum chemistry coupled with elevated antioxidant capacity in rats fed up to seven times the normal human dose and does not adversely influence any of the vital target organs. Additionally, this study reiterates the potential benefits of exposure to a pharmacologically relevant combination of phytochemicals compared to a single phytochemical entity.

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Section: Introductionmentioning

confidence: 81%

A Novel Dietary Supplement Containing Multiple Phytochemicals and Vitamins Elevates Hepatorenal and Cardiac Antioxidant Enzymes in the Absence of Significant Serum Chemistry and Genomic Changes

Bulku

Zinkovsky

Patel

et al. 2010

Oxidative Medicine and Cellular Longevity

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“…A Catuama ® , administrada oralmente a ratos por longos períodos, interferiu nos níveis de serotonina e dopamina, sugerindo-se que pode ser usada clinicamente em estágios de depressão leve e moderada, sozinha ou em associação com fármacos antidepressivos tradicionais (CAMPOS et al, 2004). PONTIERI et al (2007) observaram que a Catuama ® reverteu a fi brilação ventricular, prevenindo sua reindução e prolongando a condução intraventricular quando testada em coração de coelhos. Por outro lado, parece haver segurança no uso prolongado desse medicamento, tanto é que OLIVEIRA et al (2005) não encontraram reações adversas severas ou mudanças hematológicas ou bioquímicas em pacientes humanos que receberam a administração crônica de 25mL de Catuama ® duas vezes ao dia, por 28 dias.…”

Section: Introductionunclassified

A Catuama e o bilobalide na regeneração nervosa periférica de ratos submetidos à secção do nervo isquiático

Pereira

Delistoianov²,

Perotta

et al. 2014

Cienc. Rural

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“…Additional pre-clinical studies have shown a relaxant action for Catuama in corpus cavernosum strips from rabbits [5], this effect was correlated with the presence of P. cupana and T. catigua extracts. Catuama has also been found able to both revert and prevent ventricular fibrillation in the isolated rabbit heart, and T. catigua extract is probably the main agent responsible for these actions [6]. Of interest, our group has provided pharmacological and biochemical evidence on the potential antidepressant effects of the product Catuama and also for the T. catigua hydroalcoholic extract in rodents, by mechanisms primarily involving the activation of dopaminergic pathways [7, 8].…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive Activity of Trichilia catigua Hydroalcoholic Extract: New Evidence on Its Dopaminergic Effects

Viana

Maciel

Motta

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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Trichilia catigua is a native plant of Brazil; its barks are used by some local pharmaceutical companies to prepare tonic drinks, such as Catuama. The present study was addressed to evaluate the effects of T. catigua hydroalcoholic extract in mouse nociception behavioral models, and to evaluate the possible mechanisms involved in its actions. Male Swiss mice were submitted to hot-plate, writhing and von Frey tests, after oral treatment with T. catigua extract (200 mg kg−1, p.o.). The extract displayed antinociceptive effect in all three models. For characterization of the mechanisms involved in the antinociceptive action of the extract, the following pharmacological treatments were done: naloxone (2.5 mg kg−1, s.c.), SR141716A (10 mg kg−1, i.p.), SCH23390 (15 μg kg−1, i.p.), sulpiride (50 mg kg−1, i.p.), prazosin (1 mg kg−1, i.p.), bicuculline (1 mg kg−1, i.p.) or dl-p-chlorophenylalanine methyl ester (PCPA, 100 mg kg−1, i.p.). In these experiments, the action of T. catigua extract was evaluated in the hot-plate test. The treatment with SCH23390 completely prevented the antinociceptive effect, while naloxone partially prevented it. The possible involvement of the dopaminergic system in the actions of T. catigua extract was substantiated by data showing the potentiation of apomorphine-induced hypothermia and by the prevention of haloperidol-induced catalepsy. In conclusion, the antinociceptive effects of T. catigua extract seem to be mainly associated with the activation of dopaminergic system and, to a lesser extent, through interaction with opioid pathway.

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The herbal drug Catuama reverts and prevents ventricular fibrillation in the isolated rabbit heart

Cited by 10 publications

References 23 publications

A Novel Dietary Supplement Containing Multiple Phytochemicals and Vitamins Elevates Hepatorenal and Cardiac Antioxidant Enzymes in the Absence of Significant Serum Chemistry and Genomic Changes

A Novel Dietary Supplement Containing Multiple Phytochemicals and Vitamins Elevates Hepatorenal and Cardiac Antioxidant Enzymes in the Absence of Significant Serum Chemistry and Genomic Changes

A Catuama e o bilobalide na regeneração nervosa periférica de ratos submetidos à secção do nervo isquiático

Antinociceptive Activity of Trichilia catigua Hydroalcoholic Extract: New Evidence on Its Dopaminergic Effects

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