The heritability of fertility makes world population stabilization unlikely in the foreseeable future

Collins, Jason; Page, Lionel

doi:10.1016/j.evolhumbehav.2018.09.001

Cited by 32 publications

(11 citation statements)

References 30 publications

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“…Ethyl 2,2-Di(1H-indol-3-yl)acetate (3a). Brown oil, yield 91%; 1 Preparation of 2,2-Di(1H-indol-3-yl)ethan-1-ol (4). At 0 °C, to tetrahydrofuran (50 mL) was slowly added LiAlH 4 (0.57 g, 15 mmol) in the stirring state.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…Facing the continuous growth of global population, high efficiency, environmental protection, and health will be the development trend of modern agriculture in the future. , Plant diseases caused by plant viruses and pathogens, known as plant cancer, are the main factors restricting the efficient production of agriculture . Tobacco mosaic virus (TMV) is one of the earliest and most well-known viruses.…”

Section: Introductionmentioning

confidence: 99%

“…1 H NMR (400 MHz, CDCl 3 ): δ 8.00 (s, 2H, indole-NH), 7.64 (d, J = 8.0 Hz, 2H, Ar−H), 7.36 (t, J = 8.4 Hz, 4H, Ar−H), 7 29. (d, J = 7.0 Hz, 1H, Ar−H), 7.18−7.24 (m, 3H, Ar−H), 6.99−7.08 (m, 5H, Ar−H), 6.63 (d, J = 7.8 Hz, 1H, CH 2 −NH), 6.17 (s, 1H, CH 2 NHCS−NH), 4.97 (t, J = 7.1 Hz, 1H, Ar 2 −CH), 4.43 (t, J = 5.4 Hz, 2H, CH 2 ); 13 C NMR (100 MHz, DMSO-d 6 ): δ 180.4, 139.6, 137.0, 130.4, 129.0, 127.2, 124.4, 123.2, 123.0, 121.4, 119.5, 118.7, 116.5, 111.9, 48.9, 33.5.…”

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confidence: 99%

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Streptindole and Its Derivatives as Novel Antiviral and Anti-Phytopathogenic Fungus Agents

Jin

Gao

Zhang

et al. 2020

J. Agric. Food Chem.

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Plant diseases caused by plant viruses and pathogens seriously affect the production and storage of food crops. With the emergence of drug resistance, it is very difficult to control. Natural products are the source of new drug discovery. Here, the natural product streptindole was found to have good antiviral activity against tobacco mosaic virus (TMV) and fungicidal activities against 14 kinds of phytopathogenic fungi. A series of derivatives of streptindole were designed, synthesized, and evaluated for their antiviral and fungicidal activities. Compounds 4, 5, 11, 12c, 12d, 13d, and 13i–13l showed higher anti-TMV activities than ribavirin (inhibitory rate: 38, 37, and 40% at 500 μg/mL for inactivation, curative, and protection activity in vivo, respectively), among which compound 12d (inhibitory rate: 57, 55, and 53% at 500 μg/mL for inactivation, curative, and protection activity in vivo, respectively) with excellent antiviral activity was further evaluated for the mode of action. The mechanism research revealed that 12d can break the three-dimensional structure of TMV coat protein (CP) through hydrogen bonds, thus inhibiting the assembly of virus particles. The molecular docking result showed that compound 12d did exhibit strong interaction with TMV CP. The derivatives of streptindole also displayed broad-spectrum fungicidal activities. The current study provided valuable insights into the antiviral and fungicidal activities of streptindole derivatives.

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Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Streptindole and Its Derivatives as Novel Antiviral and Anti-Phytopathogenic Fungus Agents

Jin

Gao

Zhang

et al. 2020

J. Agric. Food Chem.

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“…The only way this would not be true is if the aliens we contact have below replacement reproductive patterns similar to some members of our own species for the approximately 150 years of the modern demographic transition. Evolutionists have argued that even this reduction in reproduction by our own species is temporary; without any coherent evolutionary pressure to maintain low fertility we should prepare for it to increase (Burger andDe-Long 2016, Collins andPage 2019). Aliens with evolutionary pressures to reproduce could present a risk for resource conflict.…”

Section: A Moonshot For Extraterrestrial Communicationmentioning

confidence: 99%

July/August 2019 Print Issue: The Sections Edition: Moon Landing

2019

Anthropology News

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“…Since the beginning of the 21st century, the total population of the world has exceeded 7 billion. A study suggests that the population is expected to reach 11.3 billion by the end of the century and that the actual population will be much larger than currently projected . Food is a basic human need, and meeting the human demand for food while maintaining healthy ecosystems is a fundamental challenge of this century .…”

Section: Introductionmentioning

confidence: 99%

Discovery of Tryptanthrins as Novel Antiviral and Anti-Phytopathogenic-Fungus Agents

Hao

Guo

Wang

et al. 2020

J. Agric. Food Chem.

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Plant diseases seriously affect the yield and quality of crops and are difficult to control. Tryptanthrin and its derivatives (tryptanthrins) were synthesized and evaluated for their antiviral activities and fungicidal activities. We found that tryptanthrins have good antiviral activities against tobacco mosaic virus (TMV) for the first time. Most of the tryptanthrins showed higher anti-TMV activities than that of ribavirin (inhibitory rates of 40, 37, and 38% at 500 μg/mL for inactivation, curative, and protection activities in vivo, respectively). Compound 3n (inhibitory rates of 52, 49, and 54% at 500 μg/mL for inactivation, curative, and protection activities in vivo, respectively) and compound 14 (inhibitory rates of 51, 48, and 53% at 500 μg/mL for inactivation, curative, and protection activities in vivo, respectively) emerged as new antiviral lead compounds with excellent antiviral activities. Compound 16 was selected for further antiviral mechanism research, which revealed that compound 16 could inhibit virus assembly by decomposing 20S coat protein (CP) disk. Molecular docking results showed that compounds 3n and 14, which have higher antiviral activities in vivo than that of compound 16, do show stronger interaction with TMV CP. Further fungicidal activity tests showed that tryptanthrins displayed broad-spectrum fungicidal activities, especially for compound 16. These compounds showed good selectivity to Physalospora piricola. In the current study, a small molecular library of tryptanthrin was constructed and the bioactivity spectrum of these compounds was broadened, which lays a foundation for their application in plant protection.

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The heritability of fertility makes world population stabilization unlikely in the foreseeable future

Cited by 32 publications

References 30 publications

Streptindole and Its Derivatives as Novel Antiviral and Anti-Phytopathogenic Fungus Agents

Streptindole and Its Derivatives as Novel Antiviral and Anti-Phytopathogenic Fungus Agents

July/August 2019 Print Issue: The Sections Edition: Moon Landing

Discovery of Tryptanthrins as Novel Antiviral and Anti-Phytopathogenic-Fungus Agents

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