The heritability of vocal tract structures estimated from structural MRI in a large cohort of Dutch twins

Dediu, Dan; Jennings, Emily; Ent, Dennis van’t; Moisik, Scott R.; Pisa, Grazia Di; Schulze, Janna; Geus, E.J.C. de; Braber, Anouk den; Dolan, Conor V.; Boomsma, Dorret I.

doi:10.1007/s00439-022-02469-2

Cited by 2 publications

(1 citation statement)

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“…Twin studies indicate that there are genetic influences on voice pitch and other voice characteristics (26)(27)(28). Various vocal tract components are also heritable (29)(30)(31), raising the possibility that vowel formants-while clearly influenced by culture and context -might have a genetic component, because vowel formants are affected by the vocal tract. However, as large-scale genetic studies of these measures have not been conducted to date, their heritability as calculated from single-nucleotide polymorphisms (SNPs) is unknown.…”

Section: Introductionmentioning

confidence: 99%

Sequence variants affecting voice pitch in humans

et al. 2023

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The genetic basis of the human vocal system is largely unknown, as are the sequence variants that give rise to individual differences in voice and speech. Here, we couple data on diversity in the sequence of the genome with voice and vowel acoustics in speech recordings from 12,901 Icelanders. We show how voice pitch and vowel acoustics vary across the life span and correlate with anthropometric, physiological, and cognitive traits. We found that voice pitch and vowel acoustics have a heritable component and discovered correlated common variants in ABCC9 that associate with voice pitch. The ABCC9 variants also associate with adrenal gene expression and cardiovascular traits. By showing that voice and vowel acoustics are influenced by genetics, we have taken important steps toward understanding the genetics and evolution of the human vocal system.

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Section: Introductionmentioning

confidence: 99%

Sequence variants affecting voice pitch in humans

et al. 2023

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Research in methodologies for modelling the oral cavity

Shahid,

French,

Valstar

et al. 2024

Biomed. Phys. Eng. Express

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The paper aims to explore the current state of understanding surrounding in silico oral modelling. This involves exploring methodologies, technologies and approaches pertaining to the modelling of the whole oral cavity; both internally and externally visible structures that may be relevant or appropriate to oral actions. Such a model could be referred to as a “complete model” which includes consideration of a full set of facial features (i.e. not only mouth) as well as synergistic stimuli such as audio and facial thermal data. 3D modelling technologies capable of accurately and efficiently capturing a complete representation of the mouth for an individual have broad applications in the study of oral actions, due to their cost-effectiveness and time efficiency.This review delves into the field of clinical phonetics to classify oral actions pertaining to both speech and non-speech movements, identifying how the various vocal organs play a role in the articulatory and masticatory process. Vitaly, it provides a summation of 12 articulatory recording methods, forming a tool to be used by researchers in identifying which method of recording is appropriate for their work. After addressing the cost and resource-intensive limitations of existing methods, a new system of modelling is proposed that leverages external to internal correlation modelling techniques to create a more efficient models of the oral cavity.The vision is that the outcomes will be applicable to a broad spectrum of oral functions related to physiology, health and wellbeing, including speech, oral processing of foods as well as dental health. The applications may span from speech correction, designing foods for the aging population, whilst in the dental field we would be able to gain information about patient’s oral actions that would become part of creating a personalised dental treatment plan.

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The heritability of vocal tract structures estimated from structural MRI in a large cohort of Dutch twins

Cited by 2 publications

References 82 publications

Sequence variants affecting voice pitch in humans

Sequence variants affecting voice pitch in humans

Research in methodologies for modelling the oral cavity

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