The Heterochromatin Condensation State in Peripheral “Gene Poor” and Central “Gene Rich” Nuclear Regions of Less Differentiated and Mature Human Leukemic Cells: A Mini-Review with Additional Original Observations
Abstract:In the morphological cytology the heterochromatin is one of very useful tools for the cell identification including the differentiation and maturation stage. However, the heterochromatin condensation state was less studied although it appeared to be different in "gene rich" central and "gene poor" peripheral nuclear regions. The heavy heterochromatin condensation state in the central "gene rich" nuclear regions might reflect a marked structural stability and protect the genomic integrity. It must be also noted… Show more
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