The heterogeneous immune microenvironment in breast cancer is affected by hypoxia-related genes

Duechler, Markus; Pęczek, Łukasz; Zuk, Karolina; Zaleśna, Izabela; Jeziorski, Arkadiusz; Czyż, Małgorzata

doi:10.1016/j.imbio.2013.09.003

Cited by 44 publications

(29 citation statements)

References 61 publications

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“…Furthermore, accumulating evidence indicates that cancer immune suppression can be driven by hypoxia (37,38). We detected that the basal subtype is highly enriched for HIF1A signaling.…”

Section: Discussionmentioning

confidence: 73%

Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes

Keck

Zuo

Khattri

et al. 2015

Clinical Cancer Research

327

319

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“…Furthermore, accumulating evidence indicates that cancer immune suppression can be driven by hypoxia (37,38). We detected that the basal subtype is highly enriched for HIF1A signaling.…”

Section: Discussionmentioning

confidence: 73%

Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes

Keck

Zuo

Khattri

et al. 2015

Clinical Cancer Research

327

319

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show abstract

“…Some reports of a positive correlation between HIF‐1α and FOXP3/Tregs may be explained by trans‐association between HIF‐1α and FOXP3/Tregs, i.e., HIF‐1α ‐expressing DCs/tumor cells upregulating FOXP3 /Tregs. For example, HIF‐1α mRNA expression in breast cancer specimens is positively correlated with FOXP3 mRNA and CD8 + Tregs numbers . Similarly, in non‐small cell lung cancer (NSCLC) patients, CD4 + CD25 + Tregs counts in peripheral blood are positively correlated with pathogenic grade and clinical stage of NSCLC and with the expression of HIF‐1α in NSCLC tissues .…”

Section: Hif‐1α and Tregs In Pathogenic Microenvironmentsmentioning

confidence: 99%

Hypoxia-inducible factor 1α plays a predominantly negative role in regulatory T cell functions

Hsu

Lai

2018

Journal of Leukocyte Biology

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Hypoxia-inducible factor 1α (HIF-1α) regulates cellular responses to hypoxia. However, conflicting roles for HIF-1α in the functions of regulatory T cells (Tregs) have been reported. In this review, we summarize observations on the requirement for HIF-1α for FOXP3 expression and Tregs development, as well as for HIF-1α-mediated downregulation of FOXP3 and Tregs destabilization. We also examine the association of HIF-1α with Tregs under pathogenic conditions. Based on these findings, we suggest that HIF-1α mainly plays a detrimental role in the function and stability of Tregs and that HIF-1α is disposable for the development and suppressive function of Tregs.

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“…The microenvironment is influenced by the specific structures, functions, and metabolism of neoplastic lesions, and by the inner environment of tumor cells. Tumor cells use autocrine and paracrine mechanisms to alter and maintain conditions essential for tumor survival, development, proliferation, and progression 63. Recent advancements in the areas of oncology and molecular biology have helped elucidate the association between malignant breast tumor and the immune factors around the tumors.…”

Section: Tumor Microenvironmentmentioning

confidence: 99%

Mechanism of immune evasion in breast cancer

Wang¹,

Zhang²,

Song³

et al. 2017

OTT

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Breast cancer (BC) is the most common malignant tumor among women, with high morbidity and mortality. Its onset, development, metastasis, and prognosis vary among individuals due to the interactions between tumors and host immunity. Many diverse mechanisms have been associated with BC, with immune evasion being the most widely studied to date. Tumor cells can escape from the body’s immune response, which targets abnormal components and foreign bodies, using different approaches including modification of surface antigens and modulation of the surrounding environment. In this review, we summarize the mechanisms and factors that impact the immunoediting process and analyze their functions in detail.

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The heterogeneous immune microenvironment in breast cancer is affected by hypoxia-related genes

Cited by 44 publications

References 61 publications

Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes

Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes

Hypoxia-inducible factor 1α plays a predominantly negative role in regulatory T cell functions

Mechanism of immune evasion in breast cancer

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