The Heteropagus Conjoined Twins of NDU Sule, Nigeria

Mabogunje, O A; Lawrie, J. H.

doi:10.1177/000992287801701111

Cited by 15 publications

(14 citation statements)

References 8 publications

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“…Among the organs identified in the parasite's pelvic cavity were a single, centrally-placed kidney with prominent cystic changes, an attached ureter, and urinary bladder. Similar findings were recorded previously [Husain et al, 1989;Mabogunje and Lawrie, 1978;Potter, 1961;Yasuda et al, 1984], but to our knowledge, the finding of a well-formed prostate (Fig. 3) in the absence of male gonadal tissue has never been reported in parasitic twins.…”

Section: Discussionsupporting

confidence: 92%

“…2). In addition, the parasite's left leg lacked a fibula; similar skeletal defects were recorded previously in CT [Mabogunje and Lawrie, 1978;Tan et al, 1974].…”

Section: Discussionsupporting

confidence: 78%

“…The pathogenesis of parasitic CT is not well understood [Machin, 1993]; it has been recommended that all cases of parasitic twins be reported in order to develop a better understanding of this rare entity [Mabogunje and Lawrie, 1978;Sathiakumar et al, 1988]. Unlike polyzygotic gestation, there is no relation with maternal age, state of parity, or history of twins.…”

Section: Discussionmentioning

confidence: 99%

“…Absence of anal orifice was described previously [Joubert and Stephanov, 1983;Mabogunje and Lawrie, 1978] (Fig. 2).…”

Section: Discussionmentioning

confidence: 99%

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Heteropagus conjoined twins due to fusion of two embryos: Report and review

Logroño

García-Lithgow²,

Harris³

et al. 1997

Am. J. Med. Genet.

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We report on a case of conjoined twinning (CT) consistent with fusion of two embryos followed by resorption of the cranial half of one of them, resulting in a normal male baby with the lower half of a male parasitic twin fused to his chest. Fluorescent in situ hybridization (FISH) studies suggested that the parasitic twin was male, and DNA typing studies demonstrated dizygosity. Although incomplete fission is the usual explanation for conjoined twins, the unusual perpendicular orientation of the parasite to the autosite supports a mechanism observed in mares in which early fusion of two embryos is followed by resorption due to compromised embryonic polarity.

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Section: Discussionsupporting

confidence: 92%

“…2). In addition, the parasite's left leg lacked a fibula; similar skeletal defects were recorded previously in CT [Mabogunje and Lawrie, 1978;Tan et al, 1974].…”

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

“…Absence of anal orifice was described previously [Joubert and Stephanov, 1983;Mabogunje and Lawrie, 1978] (Fig. 2).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Heteropagus conjoined twins due to fusion of two embryos: Report and review

Logroño

García-Lithgow²,

Harris³

et al. 1997

Am. J. Med. Genet.

View full text Add to dashboard Cite

show abstract

“…To our knowledge, only 27 cases have been reported in the English literature. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] In some cases, the parasite was attached to the chest wall of the autosite, but these cases were still categorized as epigastric heteropagus. 2,7,12,13 In epigastric heteropagus, the parasite usually has a rudimentary upper part of the body, a pelvic bone, visceral organs such as a bladder, kidney, genitourinary organs, gastrointestinal tract, and lower limbs, but the pattern of abnormalities differs from that in caudal duplication (dipygus).…”

Section: Introductionmentioning

confidence: 99%

Bizarre Presentation of Epigastric Heteropagus: Report of a Case

et al. 2006

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We report an unusual case of epigastric heteropagus in a female neonate. The parasite had a single lung as well as a liver, stomach, intestine, pancreas, ovaries, a single kidney, and a bladder. These visceral organs were located in the abdominal and pelvic space of the autosite, and the pelvic bone and lower legs of the parasite were fused with the respective organs in the autosite. The infant underwent operations to remove the central leg and some of the intra-abdominal organs of the parasite, but she must still undergo further surgery to remove the genitourinary organs and pelvic bones of the parasite, and repair her very abducted and rotated right leg.

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Craniofacial microsomia in a parasite of a heteropagus conjoined twin: A clinical and histopathologic evaluation

Silbermann

Bar-Maor²,

Auslander³

1984

Head Neck

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This report evaluates a rare case of craniofacial microsomia in a partially developed, malformed heteropagus conjoined twin. In this instance, several major components of the craniofacial complex were involved: bones, cartilage, teeth, salivary glands, auditory apparatus, cerebrum, cranial nerves, and ocular neuroepithelium. In addition, cervical vertebrae and appendicular long bones were markedly affected. To date, the underlying disorder (whether genetic, metabolic, or environmental) responsible for the development of this congenital malformation is not fully understood. Our clinical and pathologic examinations tend to suggest that an apparent lack of an adequate arterial blood supply to the growing embryo could have contributed to the elaboration of this complex syndrome. The fact that the parasite's blood supply relied mainly upon a single, medium-sized artery (1.5 mm in diameter) could have brought about local ischemic milieus during the critical phases of embryogenesis; hence, impeding the preprogrammed migration of neural crest cells to their end targets in the upper branchial arches. In such a case, the normal sequence of cell differentiation is damaged, which in turn imposes a severe impact on the morphogenesis of the various tissues composing the craniofacial complex.

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The Heteropagus Conjoined Twins of NDU Sule, Nigeria

Cited by 15 publications

References 8 publications

Heteropagus conjoined twins due to fusion of two embryos: Report and review

Heteropagus conjoined twins due to fusion of two embryos: Report and review

Bizarre Presentation of Epigastric Heteropagus: Report of a Case

Craniofacial microsomia in a parasite of a heteropagus conjoined twin: A clinical and histopathologic evaluation

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