The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation
Saurabh S. Kulkarni,
Rachel E. Stephenson,
Sarah Amalraj
et al.
Abstract:Mutations in CCDC11 (cfap53) have been identified in multiple patients with heterotaxy (Htx), a disorder of left–right (LR) patterning of the internal organs. In Xenopus, depletion of Ccdc11 causes defects in LR patterning, recapitulating the patient phenotype. Upon Ccdc11 depletion, monociliated cells of the Left–Right Organizer (LRO) exhibit multiple cilia per cell. Unexpectedly, we found that Ccdc11 is necessary for successful cytokinesis, explaining the multiciliation phenotype observed in Ccdc11‐depleted … Show more
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