2024
DOI: 10.3390/ijms251910757
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The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms

Daniel Guerreiro Diniz,
João Bento-Torres,
Victor Oliveira da Costa
et al.

Abstract: With the aging of the global population, neurodegenerative diseases are emerging as a major public health issue. The adoption of a less sedentary lifestyle has been shown to have a beneficial effect on cognitive decline, but the molecular mechanisms responsible are less clear. Here we provide a detailed analysis of the complex molecular, cellular, and systemic mechanisms underlying age-related cognitive decline and how lifestyle choices influence these processes. A review of the evidence from animal models, hu… Show more

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