The Hidden Impact of the COVID-19 Pandemic on Routine Childhood Immunization Coverage in Cameroon

Abstract

Background: The third round of the global pulse survey demonstrated that the abrupt and rapid progression of the COVID-19 pandemic significantly disrupted childhood immunization in many countries. Although Cameroon has reported over 120,000 COVID-19 cases, the reported national childhood vaccination coverage during the pandemic seems to have increased compared to that during the pre-COVID-19 period. Indeed, the first dose of the diphtheria, tetanus, and pertussis-containing vaccine (DTP-1) coverage increased from 85.4% in 2019 to 87.7% in 2020, and DTP-3 coverage increased from 79.5% in 2019 to 81.2% in 2020. The paucity of literature on the impact of COVID-19 on childhood vaccination in COVID-19 hotspot regions poses a challenge in developing a context-specific immunization recovery plan, hence the need to conduct this study. Methodology: We conducted a cross-sectional study using 2019 (pre-pandemic period) and 2020 (pandemic period) district childhood immunization data from the DHIS-2 database, weighted using completeness for each data entry against regional data completeness in 2020. Based on COVID-19 incidence, two hotspot regions were selected, with all districts (56/56) included in the final analysis. The Chi-square test was used to compare DTP-1 and DTP-3 coverage during the pre-pandemic and pandemic periods. Results: In the two hotspot regions, 8247 children missed DTP-1, and 12,896 children did not receive DTP-3 vaccines in the pandemic period compared to the results from the pre-pandemic period. Indeed, there was a significant drop in DTP-1 and DTP-3 coverage of 0.8% (p = 0.0002) and 3.1% (p = 0.0003), respectively, in the Littoral Region. Moreover, the Centre Region reported a 5.7% (p < 0.0001) and 7.6% (p < 0.0001) drop in DTP-1 and DTP-3 coverage, respectively. Most districts in the hotspot regions reported a decline in childhood immunization access (62.5%) and utilization (71.4%). Indeed, in the Littoral Region, 46% (11/24) and 58% (14/24) of districts experienced decreased vaccination access and utilization, respectively. Meanwhile, 75% (24/32) and 81% (26/32) of districts in the Centre Region experienced a drop in vaccination access and utilization, respectively. Conclusion: This study reported a situation where the national immunization indicators mask the impact of COVID-19 on childhood immunization in heavily hit regions. Therefore, this study presents valuable information for ensuring continuous vaccination service delivery during public health emergencies. The findings could also contribute to developing an immunization recovery plan and informing policy on future pandemic preparedness and response.

COVID-19 Impact on DTP Vaccination Trends in Africa: A Joinpoint Regression Analysis

“…National coverage rates may have held steady or even increased during the pandemic, masking regions where they have fallen due to the pandemic. That happened in Cameroon, where the increase in vaccination coverage masked the impact of COVIC−19 on the vaccination of children in COVID–19 hotspot regions [ 51 ]. A study in Zimbabwe found that the prevalence of missed opportunities for vaccination was 9% among mothers with no education and 21% among educated mothers.…”

Status of Routine Immunization Coverage in the World Health Organization African Region Three Years into the COVID-19 Pandemic

“…The COVID-19 pandemic has substantially disrupted routine immunization services in the World Health Organization (WHO) African Region, leading to precipitous decline in childhood vaccination rates compared to pre-pandemic levels [1][2][3][4]. The African region is one of the six regions of the WHO and is made up of 47 out the 54 countries of the African continent [5].…”

Inequality in Immunization: Holding on to Equity as We ‘Catch Up’

“…The Special Issue features research, reviews, and commentaries that span a range of immunization topics and populations. While there is an emphasis on childhood vaccinations [ 15 , 16 , 17 , 18 ]—exploring inequalities in DTP and measles-containing vaccine (MCV) coverage [ 19 , 20 , 21 , 22 , 23 ] and patterns of inequality in unvaccinated or zero-dose children [ 24 , 25 , 26 , 27 , 28 , 29 ]—contributions also cover inequalities in adult immunization [ 30 ], including protection of pregnant women and their newborns against tetanus [ 31 ] and COVID-19 vaccination [ 32 , 33 ].…”

“…An encouraging observation while putting together this Special Issue has been the use of a variety of data sources to assess immunization inequalities. Studies have made use of traditional sources of immunization data like administrative data [ 19 , 23 , 32 ] and population surveys [ 18 , 21 , 22 , 27 , 29 , 30 ] (including Demographic and Health Surveys and/or Multiple Indicator Cluster Surveys [ 15 , 20 , 31 ]), while several other studies explored the potential of novel sources such as geospatial data [ 24 , 25 ], electronic immunization registries [ 34 ], dialogues [ 16 ], country appraisals and reports [ 35 ], and funding proposals [ 26 ]. Three review studies relied on synthesis and structured analyses drawing from a multitude of existing studies [ 17 , 33 , 36 ].…”