1990
DOI: 10.1016/0022-3468(90)90212-r
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The hidden mortality in surgically treated necrotizing enterocolitis: Fungal sepsis

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Cited by 25 publications
(9 citation statements)
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“…Several risk factors have been shown to predispose neonates and young infants to invasive candidiasis [35]. Such risk factors include major congenital malformations and damaged gastrointestinal mucosa because of NEC or after bowel surgery [36][37][38]. The importance of every single factor is difficult to evaluate because, in most cases, they may be all present in the patient at the same time, as demonstrated in the current study.…”
Section: Discussionmentioning
confidence: 84%
“…Several risk factors have been shown to predispose neonates and young infants to invasive candidiasis [35]. Such risk factors include major congenital malformations and damaged gastrointestinal mucosa because of NEC or after bowel surgery [36][37][38]. The importance of every single factor is difficult to evaluate because, in most cases, they may be all present in the patient at the same time, as demonstrated in the current study.…”
Section: Discussionmentioning
confidence: 84%
“…Long-term survival was 75% overall with 65% long-term survival for surgical patients in the 1983-1990 era [110]. Fungal sepsis has been identified as a significant factor in the mortality of surgically treated infants with NEC [111].…”
Section: Resultsmentioning
confidence: 99%
“…In a previous publication, Karlowicz 6 proposed that amphotericin B be considered in neonates who weigh Ͻ1000 g and have stage IIIB NEC, "especially in those with a history of prolonged umbilical vessel catheterization, prolonged antibiotic therapy, and prolonged intubation." In a report on neonates with NEC, Smith et al 14 recommend amphotericin B for patients who remain symptomatic despite negative bacterial cul- (14) 21 (8) * P ϭ .005. † P ϭ .002.…”
Section: Discussionmentioning
confidence: 99%