The hidden mortality of congenital diaphragmatic hernia: a 20-year review

Brownlee, Ewan; Howatson, A.F.; Davis, Carl; Sabharwal, Atul J.

doi:10.1016/j.jpedsurg.2008.10.076

Cited by 87 publications

(63 citation statements)

References 7 publications

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“…in a tertiary clinic, was a risk factor for early mortality in this study. This may be explained by the fact that mortality is not always reported in pregnancy terminations, stillbirths and outborn children who die shortly after birth [37] . As a consequence, the mortality rate for inborn children with CDH may be relatively higher.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Chronic Lung Disease and Mortality in Newborns with Congenital Diaphragmatic Hernia

et al. 2010

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Background: Congenital diaphragmatic hernia (CDH) is associated with a mortality rate of 10–35% in live-born infants. Moreover, CDH survivors have a substantial risk of developing long-term pulmonary sequelae, such as bronchopulmonary dysplasia (BPD). Objectives: This study aims to evaluate risk factors associated with BPD and mortality in neonates with CDH, with particular focus on the initial ventilation mode. Methods: Eligible for inclusion were live-born infants with CDH born from 2001 through 2006 at the centers participating in the CDH Study Group. BPD (defined as oxygen dependency at day 30) and/or mortality by day 30 served as the primary endpoint. Results: A total of 2,078 neonates were included in the analysis. At day 30, 56% of the patients had either died or met the criteria for BPD. In infants who survived until day 30, the prevalence of BPD was 41%. The overall mortality rate was 31%. High-frequency oscillatory ventilation as initial ventilation mode, a right-sided defect, a prenatal diagnosis, a lower Apgar score at 5 min, a cardiac anomaly, a chromosomal anomaly and a lower gestational age were all associated with BPD and/or mortality by day 30. Conclusions: Despite improvements in neonatal care, the rates of BPD and early mortality in newborns with CDH are still considerable. Several important risk factors for a worse outcome are reported in this nonrandomized prospective observational study.

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Chronic Lung Disease and Mortality in Newborns with Congenital Diaphragmatic Hernia

et al. 2010

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“…It affects approximately 1 in 5000 births [3], and although CDHs have been reported in association with VACTERL anomalies [3,4], these are generally left-sided hernias. The incidence of CDH is 1:2000 to 1:5000 [5]; right-sided hernias are the minority, and thus, their coexistence with VACTERL would be expected to be exceedingly rare and has not been described in the literature.…”

Section: Discussionmentioning

confidence: 99%

Right-sided congenital diaphragmatic hernia, hepatic pulmonary fusion, duodenal atresia, and imperforate anus in an infant

Castle¹,

Naik‐Mathuria²,

Torres³

2011

Journal of Pediatric Surgery

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“…Overall mortality rate for liveborn infants with isolated congenital diaphragmatic hernia remains as high as 20% to 50% [1]. Congenital diaphragmatic hernia is a complex syndrome characterized by pulmonary hypoplasia and pulmonary vascular abnormalities that contribute to high pulmonary vascular resistance after birth.…”

mentioning

confidence: 99%

Terlipressin as rescue therapy for refractory pulmonary hypertension in a neonate with a congenital diaphragmatic hernia

Stathopoulos¹,

Nicaise²,

Michel³

et al. 2011

Journal of Pediatric Surgery

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The hidden mortality of congenital diaphragmatic hernia: a 20-year review

Cited by 87 publications

References 7 publications

Risk Factors for Chronic Lung Disease and Mortality in Newborns with Congenital Diaphragmatic Hernia

Risk Factors for Chronic Lung Disease and Mortality in Newborns with Congenital Diaphragmatic Hernia

Right-sided congenital diaphragmatic hernia, hepatic pulmonary fusion, duodenal atresia, and imperforate anus in an infant

Terlipressin as rescue therapy for refractory pulmonary hypertension in a neonate with a congenital diaphragmatic hernia

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