2020
DOI: 10.1038/s41388-020-01517-3
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The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis

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Cited by 20 publications
(13 citation statements)
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“…For subsequent analyses, we focused on miR-139-3p (the passenger strand) target genes, according to our previous studies emphasizing the novel roles of miRNA passenger strands. Among these target genes, we focused on PXN , which showed the most significant association with RCC patient survival in the multivariate analysis and has been reported previously as an oncogene in other types of cancers [ 18 , 19 ].…”
Section: Resultsmentioning
confidence: 99%
“…For subsequent analyses, we focused on miR-139-3p (the passenger strand) target genes, according to our previous studies emphasizing the novel roles of miRNA passenger strands. Among these target genes, we focused on PXN , which showed the most significant association with RCC patient survival in the multivariate analysis and has been reported previously as an oncogene in other types of cancers [ 18 , 19 ].…”
Section: Resultsmentioning
confidence: 99%
“…PXN is an important component of the focal adhesion complex, which is related to the occurrence, development and metastasis of human cancer, and is related to the poor clinical prognosis of tumor patients, which has been reported in many previous studies [19][20][21]. PXN is directly regulated by ETV4, and its overexpression is related to the poor prognosis of human NSCLC [22].…”
Section: Discussionmentioning
confidence: 96%
“…Hyperactivation of the enzyme leads to excessive bleeding, and the decreased activity leads to inhibition of fibrinolysis processes that can lead to thrombosis and embolism. Suppression of PXN in ovarian cancer mouse models reduces the number of blood vessels, tumor growth, and metastatic spreading [ 22 ].…”
Section: Vascularization As a Predictor At Cancermentioning
confidence: 99%