The High Diversity and Variable Susceptibility of Clinically Relevant Acremonium-Like Species in China

Yao, Limin; Wang, Hong; Wan, Zhe; Li, Ruoyu; Yu, Jin

doi:10.1007/s11046-019-00399-8

Cited by 13 publications

(13 citation statements)

References 41 publications

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“…Taking into account, the underlying diseases presented by the patient as well as its immune state would be extremely useful for anticipating or predicting the best course of medical action. Diagnosis should include molecular analysis of the fungal isolate (in these cases by sequencing the molecular markers ITS, LSU, SSU or EF1-α) [3][4][5][6] in order to assess in a more detailed and safe manner the steps regarding therapies and treatments. It is of note that most treatment in the reviewed cases was based on AMB therapy (Table 1), which contrasts with the available in vitro susceptibility data, 1,8,26,148,149 and also with the in vivo data retrieved from murine models, in which, very interestingly, PSC and the combination AFG + PSC were the treatments with the most favourable outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous cases of nail infection can be also attributed to this species 13,14 although the fungus was probably a mere contaminant in some of them. Additionally, a recent Chinese study sequenced 15 more strains of this species, most of them from nail samples 6 …”

Section: Taxonomy and Clinically Relevant Speciesmentioning

confidence: 99%

“…3 Identification of most of these fungi is doubtful because, in most of the reported cases, it is generally based only on morphological criteria and, considering the complexity of the taxonomy of these genera, molecular confirmation is essential. Sequencing of the ITS fungal barcode and the actin gene has been carried out to molecularly identify species within these genera 3,5 ; however, other molecular markers such the ribosomal large subunit (LSU), the ribosomal small subunit (SSU) 4 and the elongation factor 1-α (EF1α) 6 are also phylogenetically informative.…”

mentioning

confidence: 99%

“…Additionally, a recent Chinese study sequenced 15 more strains of this species, most of them from nail samples. 6 Several other species of Acremonium have also been reported to cause infections, although their role as causing agents in the clinical manifestations and correct identification has not been molecularly proven. These are as follows:…”

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confidence: 99%

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SarocladiumandAcremoniuminfections: New faces of an old opportunistic fungus

Pérez-Cantero

Guarro

2020

Mycoses

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The genera Sarocladium and Acremonium (order Hypocreales) are a very diverse group of morphologically and genetically related fungi that are generally found in the environment. Numerous species of these genera are soil saprobes and opportunistic pathogens of plants, other fungi, animals or humans. 1 They are distributed worldwide, and Acremonium isolates have even been found in rocks on continental Antarctica. 2 In addition, these fungi are very relevant in the clinical field, as they have been proven to be involved in a wide range of human conditions and manifestations. As will be discussed later, diagnosis and management of these infections are quite challenging, mostly due to the difficulties in the correct identification and to the poor antifungal response they generally show. As a matter of fact, Acremonium and Sarocladium species cannot be distinguished by histopathological examination from some other opportunistic fungi, such as Fusarium and its relatives; therefore, DNA sequence analysis is required. This review, based on an exhaustive literature search of the PubMed database, compiles and discusses the current knowledge of Sarocladium and Acremonium infections in terms of taxonomy, clinical presentations and prognoses, diagnosis, treatment, outcomes, antifungal susceptibility and their impact in animals.

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Section: Discussionmentioning

confidence: 99%

Section: Taxonomy and Clinically Relevant Speciesmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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SarocladiumandAcremoniuminfections: New faces of an old opportunistic fungus

Pérez-Cantero

Guarro

2020

Mycoses

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“…Although there have been some reports of S. strictum infections in humans, most of them were derived from skin or blood, and the brain is considered one of the least susceptible organs ( 3 ). Until now, S. strictum meningoencephalitis has been reported only in three immunodeficient patients, all of whom died within a short time ( 4 ). Here, we report a case of an apparently immunocompetent young woman who presented with severe headache and slight fever after undergoing a transnasal endoscopic repair of cerebrospinal fluid (CSF) rhinorrhea.…”

Section: Introductionmentioning

confidence: 99%

Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation

et al. 2021

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As an opportunistic phytopathogen, Sarocladium strictum has only been shown to cause neurological disease in immunocompromised patients, where antifungal therapy was not effective. We report a case of Sarocladium strictum meningoencephalitis in an apparently immunocompetent young woman who presented with severe headache and slight fever after undergoing transnasal endoscopic repair of cerebrospinal fluid rhinorrhea. Chronic sinusitis and suspicious intracranial fungal lesions were observed on enhanced magnetic resonance imaging (MRI). Both culture and metagenomic next-generation sequencing of her cerebrospinal fluid were positive for Sarocladium strictum. After local debridement, treatment with amphotericin B plus voriconazole and Ommaya reservoir implantation, the patient improved significantly. Unfortunately, her symptoms worsened again despite plenty of antifungal therapy for a month.

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