The high dose unfractionated heparin is related to less radial artery occlusion rates after diagnostic cardiac catheterisation: a single centre experience

Beşli, Feyzullah; Gungoren, Fatih; Tanriverdi, Zulkif; Taşçanov, Mustafa Beğenç; Fedai, Halil; Akcali, Huseyin; Demirbağ, Recep

doi:10.1080/00015385.2019.1705584

Cited by 7 publications

(6 citation statements)

References 25 publications

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“…RAO was seen in 25 (23.4%) patients in our study. Post-procedure RAO has been observed at 1 to 38% in large-center, multiparticipant studies (25). Our study's high rate of radial occlusion (23.4%) may have been due to the operators' lack of experience in CAG procedures performed using the transradial artery and a manual compression method with a classical radial bandage homeostasis control.…”

Section: Discussionmentioning

confidence: 66%

The protective role of low-dose acetylsalicylic acid use and relation with inflammatory and thrombotic parameters on radial artery occlusion in patients undergoing elective transradial coronary angiography

Özbeyaz¹,

AÇIKEL>

Algül

et al. 2022

Journal of Health Sciences and Medicine

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Aim: Transradial angiography (TRA) is recommended in clinical practice; it is better than the transfemoral route to prevent site-related complications. Radial artery occlusion is one of the most seen significant complications after TRA. In the present study, the protective effect of low dose acetylsalicylic acid (ASA) use against the radial artery occlusion (RAO) and the predictive ability of some thrombotic and inflammatory factors for the development of RAO were investigated. Material and Method: One thousand two hundred fifty-four patients who planned for elective coronary angiography were screened to include transradial coronary angiography. The patients have grouped group I, who took ASA (100 mg) (n= 56), and group II (n= 51), who did not. Blood samples were taken immediately after sheath insertion and after the six hours of the sheath removal. The D-dimer and C-reactive protein values were analyzed between groups. In the first 24 hours after the procedure, the radial Doppler ultrasonography assessment was performed to detect RAO. Multivariable regression analysis was used to evaluate the independent risk factors for the TRA. Results: Eligible one hundred seven stable patients were included in the study. The demographic, laboratory and procedural characteristics were similar between the two groups (Table 2). TRA was statistically lower in Group I compared to Group II. (n=3 vs. n=22, p=.001). Multivariable regression analysis demonstrated that postprocedural higher D-dimer levels and non-ASA status were found to be the independent risk factors for RAO (OR (95% CI=1.235(1.014-1.582) p=.001, 5.534 (3.376-9.252), p .05). Conclusion: Preprocedural ASA use may have a protective role against the RAO. Pre- and post-procedural D-dimer levels can predict the thrombotic process in the early phase of the RAO.

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Section: Discussionmentioning

confidence: 66%

The protective role of low-dose acetylsalicylic acid use and relation with inflammatory and thrombotic parameters on radial artery occlusion in patients undergoing elective transradial coronary angiography

Özbeyaz¹,

AÇIKEL>

Algül

et al. 2022

Journal of Health Sciences and Medicine

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“…However, TRA can result in several complications; radial artery occlusion (RAO) is the most unwilling complication. Besli et al evaluated whether weightadjusted high dose UFH (100 IU/kg) reduces the rate of RAO after diagnostic cardiac catheterisation compared to weight-adjusted standard dose UFH (50 IU/ kg) in 868 consecutive patients [7]. RAO was evaluated with vascular Doppler ultrasonography at 10 days after cardiac catheterisation RAO was significantly higher in the standard dose UFH group than high dose UFH group (7.9% vs. 3.0%) with an adjusted OR of 2.8 (95% CI: 1.35-5.87, p ¼ 0.006) (see Figure 3).…”

Section: Anti-thrombotic Therapymentioning

confidence: 99%

Review article: the best of 2019

et al. 2022

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“…25,32 The selection of dose of heparin in coronary angiography depend on the calculation of patients' weight and added to complete heparinization and is not clearly determined yet. 33 The most commonly used doses of heparin are 2000IU ̶ 5000IU to prevent the complication of RAO for coronary angiography. The conventional dose is (2000IU-3000IU or 50IU/kg) and high-dose is (5000IU or 100IU/kg).…”

Section: Introductionmentioning

confidence: 99%

Heparin Low Doses and Standard Doses Effect on Trans-Radial Catheterization

Zafarullah¹,

Ahmad²,

Butt³

et al. 2022

PJMHS

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Background: Transradial artery is being utilized by an expanding number of interventional cardiologists to perform percutaneous interventions. Nevertheless, occlusion of radial artery (RAO) is prominent after transradial (TR) catheterization. Use of anticoagulant drugs is one way to prevent RAO. The conventional dose of heparin is (2000IU-3000IU or 50IU/kg) and high-dose is (5000IU or 100IU/kg). The use of high-dose heparin and standard-dose heparin is still debatable. Objective: The present study will analyze the non-randomized controlled trials of standard and high dose of heparin for the prevention of radial artery occlusion after transradial catheterization. Methodology: A prospective double-blinded non-randomized controlled trial was carried out. Demographic data related to socio-economic status such as their age, occupation, gender, and smoking habits were collected. Grouping was done so that patients may either be placed in group 1 which will receive 2500UI or into group 2 which will get 5000UI of unfractionated heparin. RAO was the key endpoint of our study. Major bleeding, hematomas and radial artery spasm were secondary outcome measure. Results: 471 patients were made part of this study. 235 patients were placed in group A which received 2500IU and 236 were placed in group B which received 5000IU. RAO was noted to be significantly higher in the group the received the standard dose of UFH as compared to the group that received high dose UFH (8 % vs. 3.3 %, p = 0.005). Female gender (OR: 2.951, 95% CI: 1.57-5.46, p = 0.002), hypertension (OR: 0.02, 95% CI: p = 0.005 and standard dose UFH (OR: 2.822, 95% CI: 1.343 – 5.911, p = . 0.007) were found to be the independent predictors of RAO. Conclusion: Weight-adjusted higher dosage of UFH in TRA for diagnosis yielded remarkable results in reducing the rates of early RAO against the standard administered dosage

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The high dose unfractionated heparin is related to less radial artery occlusion rates after diagnostic cardiac catheterisation: a single centre experience

Cited by 7 publications

References 25 publications

The protective role of low-dose acetylsalicylic acid use and relation with inflammatory and thrombotic parameters on radial artery occlusion in patients undergoing elective transradial coronary angiography

The protective role of low-dose acetylsalicylic acid use and relation with inflammatory and thrombotic parameters on radial artery occlusion in patients undergoing elective transradial coronary angiography

Review article: the best of 2019

Heparin Low Doses and Standard Doses Effect on Trans-Radial Catheterization

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