The High-Frequency Major Histocompatibility Complex Class I Allele Mamu-B ^* 17 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication

Abstract

Particular HLA alleles are associated with reduced human immunodeficiency virus replication. It has been difficult, however, to characterize the immune correlates of viral control. An analysis of the influence of major histocompatibility complex class I alleles on viral control in 181 simian immunodeficiency virus SIVmac239-infected rhesus macaques revealed that Mamu-B * 17 was associated with a 26-fold reduction in plasma virus concentrations (P < 0.001). Mamu-B * 17 was also enriched 1,000-fold in a group of animals that controlled viral replication. Even after accounting for this group, Mamu-B * 17 was associated with an eightfold reduction in plasma virus concentrations (P < 0.001). Mamu-B * 17-positive macaques could, therefore, facilitate our understanding of the correlates of viral control.

Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques: Influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV89.6P infection

“…These investigations revealed a new association of Mauritian MHC haplotype and susceptibility/resistance to SHIV 89.6P infection. The association of particular MHC alleles with resistance of rhesus macaques to SIV and SHIV infection is well established [38][39][40][41][42][43]. Our results here extend the phenomenon to cynomolgus macaques of Mauritian origin.…”

“…HLA-B*27 and B*57 are associated with delayed AIDS progression, while HLA-B*35 is associated with accelerated AIDS onset [57]. In rhesus macaques, Mamu-B*17 is associated with reduced plasma viremia and slowed disease progression following infection with SIV mac239 [40,42], although by itself it does not guarantee better disease outcome [58]. Mamu-B*08 positive rhesus macaques display reduced chronic phase viremia following SIV mac239 infection, and the allele is overrepresented in elite controllers [38].…”

Mhc class I haplotypes associated with survival time in simian immunodeficiency virus (SIV)-infected rhesus macaques

“…An association with slow disease progression has been reported for Mamu-B*17. 25,27 In our study cohort, like in other populations, 24,27 Mamu-B*17 was linked to Mamu-B*2901 (Table 2). This composite B configuration was linked to two different A regions, one of which carried Mamu-A*02.…”

“…Several studies have shown that single MHC antigens such as Mamu-A*01 and -B*17 are significantly associated with prolonged survival in SIV-infected rhesus macaques. 13,[25][26][27] However, monkeys sharing one or two of these MHC antigens may still exhibit a variable course of disease. 27,28 We therefore assessed the association between Mhc class I haplotypes, rather than single gene variants, and survival time in SIV-infected rhesus macaques.…”

“…13,[25][26][27] However, monkeys sharing one or two of these MHC antigens may still exhibit a variable course of disease. 27,28 We therefore assessed the association between Mhc class I haplotypes, rather than single gene variants, and survival time in SIV-infected rhesus macaques. In order to obtain detailed information on the Mhc class I haplotypes present in the German Primate Center (GPC) breeding colony, the monkeys which were of Indian descent, we first performed a low-resolution Mhc typing on monkeys derived from three generations.…”