The high lymphadenopathy and subcutaneous edema are associated with development of foot ulcer in type 2 diabetes: A collagen implanted antibiotic therapy

Elumalai, Karthikeyan; Yadhav, C. S.; Nishad, Shaik Sana; Srinivasan, S.; Mounika, Kamani; Sivannan, Srinivasan; Supriya, K; Kumar, Anil

doi:10.1016/j.bfopcu.2018.03.002

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…The major drawback of using natural polymer in composites is their tendency to arouse the immune response in vivo . Topical gentamicin–collagen sponge has been applied for diabetic patients with foot ulcer infection ( Elumalai et al, 2018 ; Uçkay et al, 2018 ). A systematic review reported that the eradication ratio of infections in the treatment of chronic osteomyelitis using gentamicin collagen sponge ranged from 63% to 100% ( van Vugt et al, 2018 ).…”

Section: Classification and Evaluation Of Biomaterials For Osteomyeli...mentioning

confidence: 99%

Current application and future perspectives of antimicrobial degradable bone substitutes for chronic osteomyelitis

Jiang,

Zhu,

Liu

2024

Front. Bioeng. Biotechnol.

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Chronic osteomyelitis remains a persistent challenge for the surgeons due to its refractory nature. Generally, treatment involves extensive debridement of necrotic bone, filling of dead space, adequate antimicrobial therapy, bone reconstruction, and rehabilitation. However, the optimal choice of bone substitute to manage the bone defect remains debatable. This paper reviewed the clinical evidence for antimicrobial biodegradable bone substitutes in the treatment of osteomyelitis in recent years. Indeed, this combination was proved to eradicate infection and facilitate bone reconstruction, which might reduce the cost and hospital stay. Handling was associated with increased risk of unwanted side effect to affect bone healing. The study provides some valuable insights into the clinical evaluation of treatment outcomes in the aspects of infection eradication, bone reconstruction, and complications caused by materials. However, achieving complete infection eradication and subsequently perfect bone reconstruction remains challenging in compromised conditions, hence advanced innovative bone substitutes are imperative. In this review, we mainly focus on the desired functional effects of advanced bone substitutes on infection eradication and bone reconstruction from the future perspective. Handling property was optimized to simplify surgery process. It is expected that this review will provide an important opportunity to enhance the understanding of the design and application of innovative biomaterials to synergistically eradicate infection and restore integrity and function of bone.

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Section: Classification and Evaluation Of Biomaterials For Osteomyeli...mentioning

confidence: 99%

Current application and future perspectives of antimicrobial degradable bone substitutes for chronic osteomyelitis

Jiang,

Zhu,

Liu

2024

Front. Bioeng. Biotechnol.

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Inguinal lymphadenopathy as a predicting factor for ipsilateral primary limb amputation after a successful endovascular treatment

Raskin

Khaitovich

Balan

et al. 2020

European Journal of Radiology

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The Insights of Microbes’ Roles in Wound Healing: A Comprehensive Review

2021

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A diverse range of normal flora populates the human skin and numbers are relatively different between individuals and parts of the skin. Humans and normal flora have formed a symbiotic relationship over a period of time. With numerous disease processes, the interaction between the host and normal flora can be interrupted. Unlike normal wound healing, which is complex and crucial to sustaining the skin’s physical barrier, chronic wounds, especially in diabetes, are wounds that fail to heal in a timely manner. The conditions become favorable for microbes to colonize and establish infections within the skin. These include secretions of various kinds of molecules, substances or even trigger the immune system to attack other cells required for wound healing. Additionally, the healing process can be slowed down by prolonging the inflammatory phase and delaying the wound repair process, which causes further destruction to the tissue. Antibiotics and wound dressings become the targeted therapy to treat chronic wounds. Though healing rates are improved, prolonged usage of these treatments could become ineffective or microbes may become resistant to the treatments. Considering all these factors, more studies are needed to comprehensively elucidate the role of human skin normal flora at the cellular and molecular level in a chronic injury. This article will review wound healing physiology and discuss the role of normal flora in the skin and chronic wounds.

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The high lymphadenopathy and subcutaneous edema are associated with development of foot ulcer in type 2 diabetes: A collagen implanted antibiotic therapy

Cited by 3 publications

References 19 publications

Current application and future perspectives of antimicrobial degradable bone substitutes for chronic osteomyelitis

Current application and future perspectives of antimicrobial degradable bone substitutes for chronic osteomyelitis

Inguinal lymphadenopathy as a predicting factor for ipsilateral primary limb amputation after a successful endovascular treatment

The Insights of Microbes’ Roles in Wound Healing: A Comprehensive Review

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