The high platelet counts as predictor for early foetal demise

Shao, Xiaowen; Wang, Dandan; Xu, Yixiang; Guo, Ling; Yang, Hui; Zhou, Jieru; Liang, Junquan; Qian, Jie; Cheng, Jiajing; Sun, Lihua; Xiang, Yaozu

doi:10.1080/07853890.2021.1968027

Cited by 4 publications

(5 citation statements)

References 33 publications

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“…They found that platelet counts were significantly higher in pregnant women with miscarriage compared to healthy pregnancies, and high platelet count was independently associated with an increased risk of miscarriage. 18 Therefore, the platelet count may be the reason of significant results for SII. The SII incorporates lymphocyte, neutrophil, and platelet parameters.…”

Section: Discussionmentioning

confidence: 99%

“…It also has functions in maternal‐fetal vascular remodeling 17 . Shao et al 18 evaluated the platelet counts of 99 women with miscarriage at 5–10 weeks of gestation and 170 pregnant women with an uncomplicated pregnancy. They found that platelet counts were significantly higher in pregnant women with miscarriage compared to healthy pregnancies, and high platelet count was independently associated with an increased risk of miscarriage 18 .…”

Section: Discussionmentioning

confidence: 99%

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Predicting miscarriage using systemic immune‐inflammation index

Turgut

Yıldırım

Sakcak

et al. 2022

J of Obstet and Gynaecol

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Aim: To evaluate the clinical significance of the systemic immune-inflammation index (SII) for patients who had miscarriages. Materials: The retrospective study included 709 pregnant women who had a miscarriage (nonviable intrauterine pregnancy up to 20 weeks of gestation) and 676 women who carried a viable intrauterine pregnancy up to 20 weeks of gestation-serving as the control group. The study and the control group were compared in terms of demographic characteristics, laboratory test results, and SII values. Furthermore, laboratory test results and SII values were compared between patients in the study group and the control group with a history of genital bleeding (threatened abortion). Results: The mean gestational week of pregnancy was 9.5 AE 3 for the control group and 8.3 AE 2.5 for the study group (p = 0.150). The SII values were higher in the study group than in the control group (p = 0.030). In all participants with a clinical history of genital bleeding, the leukocyte count, neutrophil count, neutrophil-to-lymphocyte ratio (NLR), and SII values were higher in the miscarriage group than the group with viable fetus (p = 0.031, p = 0.003, p = 0.002, p < 0.001). Based on a receiver operating characteristic (ROC) curve analysis, the SII cutoff value for miscarriage was 883.95 (10 9 /L) (62.6% sensitivity, 62% specificity) in patients with a clinical history of threatened abortion. Conclusion: High SII values in early pregnancy may be used as an additional marker for the prediction of miscarriage, in pregnant women with threatened abortion. Further prediction models including maternal risk factors and multiple markers may be more valuable for clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Predicting miscarriage using systemic immune‐inflammation index

Turgut

Yıldırım

Sakcak

et al. 2022

J of Obstet and Gynaecol

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“…Researchers discovered that pregnant women experiencing a miscarriage had much higher platelet counts compared to those in healthy pregnancies. Moreover, a high platelet count was revealed to be independently related with an increased risk of miscarriage [16]. The levels of CA125 are significantly different between the two sets of data (aborted and not aborted).…”

Section: Discussionmentioning

confidence: 93%

“…An analogous study by Shao et al (2021) compared the platelet counts of 170 healthy pregnant women to those of 99 women who had a miscarriage between 5 and 10 weeks into their pregnancies. A high platelet count was shown to be independently related with an increased risk of miscarriage [16], and it was also considerably greater in pregnant women who had miscarriages compared to healthy pregnancies. The two groups' CA125 levels varied significantly from one another (aborted and not aborted).…”

Section: Discussionmentioning

confidence: 99%

Role of serum cancer antigen CA-125 in the First Trimester Threatened Miscarriage

Nosseir,

Sakr,

Ahmed

et al. 2023

Benha Journal of Applied Sciences

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Background: Threatened Obstetricians are quite concerned about miscarriage occurring during the first trimester. It is still a clinical problem to identify pregnant women at risk of miscarriage early on. One promising serum biomarker for the prediction of unfavourable pregnancy outcomes is CA-125. The purpose of this research was to determine if serum CA125 has a predictive role in threats of abortion during the first trimester and in the 20-week follow-up. Methods: A cross-sectional research was conducted with 90 participants, 45 of whom were pregnant normally (Group A) and 45 of whom were pregnant with a risk of miscarriage (Group B). Following a defined procedure, thorough clinical evaluations were carried out, which included obtaining medical history, doing physical exams, conducting laboratory investigations, performing transvaginal ultrasounds, and evaluating CA-125 levels. Up to the 20th week of pregnancy, patients were monitored. It was shown that the group experiencing a miscarriage had significantly higher serum CA-125 levels (77.55 ± 26.38 IU/ml vs. 42.97 ± 14.09 IU/ml, p < 0.0001). With a sensitivity of 91.7% and specificity of 86.4%, a CA-125 cutoff value of 31.87 was associated with a statistically significant increased risk of miscarriage. Results: There is a strong correlation between elevated blood CA-125 levels and certain clinical indicators and the risk of miscarriage during the first trimester.

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“…It has been reported that the platelet activation of pregnant women with preeclampsia, fetal growth restriction, and preterm birth is higher than that of normal pregnant women and nonpregnant women ( 28 – 30 ). Increased platelet counts in the first trimester were suggested to be useful in predicting of early fetal demise ( 31 ). Our study also found that platelets were higher in pregnant women in the adverse neonatal outcome group.…”

Section: Discussionmentioning

confidence: 99%

First trimester sCD40L levels associated with adverse neonatal outcomes in euthyroid pregnant women with positive TPOAb

et al. 2023

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BackgroundsIt remained unclear whether isolated positive thyroid peroxidative antibodies (TPOAb) were associated with adverse maternal and neonatal outcomes. The purpose of this study was to observe adverse neonatal outcomes among euthyroid pregnant women with positive TPOAb and to investigate the underlying risk factors.MethodsEuthyroid pregnant women with TPOAb positivity were enrolled and followed up in our study. Adverse neonatal outcomes such as preterm birth, low birth weight, and fetal macrosomia were observed. Clinical data in the first trimester were collected and compared between groups with or without adverse neonatal outcomes. Maternal serum soluble CD40 ligand (sCD40L) was also measured at the same time.ResultsA total of 176 euthyroid pregnant women with TPOAb positivity were finally enrolled and analyzed in our study. Thirty-nine (22.16%) euthyroid women with TPOAb positivity were found to have adverse neonatal outcomes. Thirteen participants received assisted reproductive technology (ART) in our study, and seven participants were in the adverse neonatal outcome group. Preterm birth, low birth weight, and fetal macrosomia were the most common comorbidities. The proportion of receiving ART and the levels of sCD40L and platelet were significantly higher in the adverse neonatal outcome group (all P < 0.05). Multivariate regression analysis showed that sCD40L and receiving ART were the independent risk factors for adverse neonatal outcomes. The odds ratio values of sCD40L higher than 5.625 ng/ml were 2.386 [95% confidence interval (CI) = 1.017 to 5.595; P = 0.046] for overall adverse neonatal outcome, 3.900 (95% CI = 1.194 to 12.738; P = 0.024) for preterm birth, and 3.149 (95% CI = 0.982 to 10.101; P = 0.054) for low birth weight.ConclusionsApproximately one of the four euthyroid women with TPOAb positivity might have adverse neonatal outcomes. Measurement of sCD40L in first trimester might have a predictive value for adverse neonatal outcomes in euthyroid pregnant women with positive TPOAb.

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The high platelet counts as predictor for early foetal demise

Cited by 4 publications

References 33 publications

Predicting miscarriage using systemic immune‐inflammation index

Predicting miscarriage using systemic immune‐inflammation index

Role of serum cancer antigen CA-125 in the First Trimester Threatened Miscarriage

First trimester sCD40L levels associated with adverse neonatal outcomes in euthyroid pregnant women with positive TPOAb

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