The High Prevalence of Hypovitaminosis D in China

Yu, Songlin; Fang, Huiling; Han, Jun; Cheng, Xinqi; Xia, Liangyu; Li, Shijun; Liu, Min; Tao, Zhihua; Wang, Liang; Hou, Li’an; Qin, Xuzhen; Li, Pengchang; Zhang, Ruiping; Su, Wei; Qiu, Ling

doi:10.1097/md.0000000000000585

Cited by 122 publications

(91 citation statements)

References 29 publications

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“…[47][48][49] The reverse phenomenon has been reported in Finland where advancing age has been associated with higher 25-(OH) D values in both sexes up to the age of 80 and was attributed to an "active pensioner" outdoor lifestyle, increased consumption of fatty fish, as well as dairy product fortification and VitD supplement use. 20,50 Consistent with previous studies, 20,38,40,[51][52][53][54] 25-(OH) D levels in females were found to be lower compared to males, up to the age of 50 years; thereafter the levels of 25-(OH)D were not different from those of males. A plausible explanation might include VitD and calcium supplementation in post-menopausal women together with changes in circulating estrogen levels, as well as lifestyle factors not addressed in this study (e.g.…”

Section: Discussionsupporting

confidence: 79%

Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values

Katrinaki

Kampa

Margioris

et al. 2016

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Section: Discussionsupporting

confidence: 79%

Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values

Katrinaki

Kampa

Margioris

et al. 2016

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“…In a study in Chinese adults, Yu et al . reported that vitamin D status was affected by living in a coastal or inland region, rather than living in regions of different latitudes; they suggested that inland residents might have had lower vitamin D status because of lower fish oil consumption . In the present study, however, Tochigi Prefecture is an inland region, whereas Fukuoka and Kumamoto Prefectures are coastal regions.…”

Section: Discussioncontrasting

confidence: 62%

Regional differences in infant 25‐Hydroxyvitamin D: Pilot study of the Japan Environment and Children’s Study

Ayabe

Yamamoto‐Hanada

Mezawa

et al. 2017

Pediatrics International

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Background: In recent years, a resurgence in the number of infants with vitamin D deficiency has been noted. In addition to seasonal differences in exposure to ultraviolet (UV) rays, regional differences in dietary habits and lifestyles may affect susceptibility to vitamin D deficiency. No studies have been conducted, however, on infants in multiple regions of Japan to determine the extent of differences in vitamin D status. Methods: 25-Hydroxyvitamin D (25OHD) was measured on radioimmunoassay in 126 infants aged 2-4 years, who participated in the Pilot Study of the Japan Environment and Children's Study (JECS) by the Ministry of Environment of Japan. A multiple regression model with 25OHD level as the outcome variable, and season and region as explanatory variables, was generated. Results: Both region and season during which infants participated in this study significantly affected 25OHD level (P = 0.0087 and <0.0001, respectively; Wald test). Reflecting decreased exposure to UV rays, infants who were examined in winter had lower 25OHD than those examined in summer. Infants from both Fukuoka Prefecture (33°N) and Kumamoto Prefecture (32°N), however, had lower 25OHD than those from Tochigi Prefecture (36°N), contrary to expectations given the extent of UV exposure. Conclusions: Regional differences in daily habits and/or environmental factors affect 25OHD level in Japanese infants. The JECS is expected to identify those factors to provide guidance on preventing infantile vitamin D deficiency.

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“…In China, the prevalence of serum 25OHD 3 deficiency is higher than 50% in all age groups [25,26], reaching 85.8%, 97%, and 89.7% in schoolaged students, adolescents, and adults, respectively, in some remote and low-income regions [27][28][29]. The prevalence of vitamin D deficiency in schoolchildren (ages 7 to 11 y) is 56.4% in 2013 [30] and 45.85% of (ages 1 to 10 y) [31] in Harbin.…”

Section: Discussionmentioning

confidence: 99%

Nutrition assessment of vitamin A and vitamin D in northeast Chinese population based-on SPE/UPLC/PDA

Wang

Chen

et al. 2018

BMC Nutr

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Background: The aims of the current study were to assess the nutritional status of 25OHD3 and retinol in a northern Chinese population using our established reliable method for the simultaneous determination of serum 25OHD3 and retinol. Method: We established a reliable method for the simultaneous determination of 25OHD3 and retinol using SPE and UPLC/PDA; measured the serum levels of 25OHD3 and retinol in elementary school students, middle school students, and adults (n = 1181) in northern China; and assessed their nutritional status.

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The High Prevalence of Hypovitaminosis D in China

Abstract: Supplemental Digital Content is available in the text

Cited by 122 publications

References 29 publications

Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values

Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values

Regional differences in infant 25‐Hydroxyvitamin D: Pilot study of the Japan Environment and Children’s Study

Nutrition assessment of vitamin A and vitamin D in northeast Chinese population based-on SPE/UPLC/PDA

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