The design of integrated and highly efficient solutions for thermal management is a key capability for different aerospace products, ranging from civil aircraft using hydrogen on board to miniaturized satellites. In particular, this paper discloses a novel numerical tool for the design and thermal performance assessment of heat pipes. To achieve this goal, a numerical Ansys Parametric Design Language code is set up to verify the effective subtractive heat flux guaranteed by the selected heat pipe arrangement. The methodology and related tool show their ability to provide good thermal performance estimates for different heat pipe designs and operating conditions. Specifically, the paper reports two very different test cases: (1) solid metal heat pipes to cool down the crotch leading-edge area of the air intake of a Mach 8 civil passenger aircraft, and (2) a copper-water heat pipe to cool down a Printed Circuit Board of a generic small LEO satellite. The successful application of the methodology and numerical code confirms the achievement of the ambitious goal of developing in-house tools to support heat pipe thermal performance prediction for the entire aerospace domain.