The Higher Proportion of Men with Psoriasis Treated with Biologics May Be Explained by More Severe Disease in Men

Hägg, David; Eriksson, Marie; Sundström, Anders; Schmitt‐Egenolf, Marcus

doi:10.1371/journal.pone.0063619

Cited by 93 publications

(72 citation statements)

References 16 publications

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“…Male patients may exhibit a distinct biological response to etanercept compared to females, implying a different pathophysiological mechanism of psoriatic plaques. This finding is consistent with a previous report, which suggested that males exhibit more severe psoriasis, as compared with females (40). Additionally, TLR-2 and -9 may play a role as indices of severe psoriasis, since their mRNA alterations showed significant positive correlations with ΔPASI-2 in male patients that received etanercept.…”

Section: A B C Dsupporting

confidence: 92%

Effect of TNF-α inhibitors on transcriptional levels of pro-inflammatory interleukin-33 and Toll-like receptors-2 and -9 in psoriatic plaques

Vageli

Exarchou

Zafiriou

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Tumor necrosis factor (TNF)-α inhibitors are considered to be effective in the treatment of psoriatic plaques, although the precise therapeutic pathway is not clear. Pro-inflammatory molecules, such as Toll-like receptor (TLR)-2 and -9 and interleukin (IL)-33, a member of the IL-1 receptor/TLR superfamily, have been found to be expressed in psoriatic plaques. The aim of the present study was to investigate whether TNF-α inhibitor treatment has an effect on the expression of IL-33 and TLR-2 and -9 in psoriatic plaques. Seventeen patients with psoriatic plaques were treated with a TNF-α inhibitor (etanercept or infliximab) for 12 weeks in an open-label study, and the transcriptional levels of IL-33 and TLR-2 and -9 were determined by reverse transcription-quantitative polymerase chain reaction in paired biopsies of psoriatic plaques obtained at baseline (B) and following the 12 weeks of treatment (P). The psoriasis area severity index (PASI) score was also determined. At B, elevated IL-33 and TLR-2 mRNA levels were observed in all cases, while TLR-9 showed elevated mRNA levels in 76% of cases. At P, reductions in the mRNA levels of IL-33, TLR-2 and TLR-9 were observed, with TLR-2 and -9 levels exhibiting significant reductions (P<0.0001, Wilcoxon signed-rank test). PASI scores were significantly reduced by the treatment (P<0.0001, Wilcoxon signed-rank test) and the changes in PASI scores exhibited a significant positive Pearson's correlation with the P/B mRNA expression ratios of TLR-2 or -9 in males (P<0.05), particularly in the etanercept group (P<0.0001). The findings support the efficacy of anti-TNF-α treatment on the innate immune response in psoriatic skin, with a focus on TLR-2 and -9 inhibition, suggesting their role in the pathogenic mechanism of plaque psoriasis, which may be associated with gender.

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Section: A B C Dsupporting

confidence: 92%

Effect of TNF-α inhibitors on transcriptional levels of pro-inflammatory interleukin-33 and Toll-like receptors-2 and -9 in psoriatic plaques

Vageli

Exarchou

Zafiriou

et al. 2015

Experimental and Therapeutic Medicine

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“…Psoriasis is a chronic genetic inflammatory hypoproliferative disease with flaked layers (1)(2)(3)(4). The exact cause of this disease is not fully understood yet (5).…”

Section: Introductionmentioning

confidence: 99%

“…The exact cause of this disease is not fully understood yet (5). It is equally prevalent in men and women (1), affecting 1% -3% of the population worldwide (6), 3% of the American population (2), and 9% of the Iranians population (7). Moderate to severe psoriasis is associated with diseases, such as cardiovascular diseases, metabolic syndrome (1), anger, anxiety, frustration (5), increased risk of mortality (8), diabetes, hypertension, dyslipidemia (9), obesity (3), and reduced quality of life (10).…”

Section: Introductionmentioning

confidence: 99%

The Effects of a Self-Care Program on Promoting Self-Care Behaviors in Patients with Psoriasis

Karimipour

Sayadi

Shariati

et al. 2017

Jundishapur J Chronic Dis Care

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Background: Psoriasis is a chronic inflammatory disease with frequent recurrence. The associated complications cause disturbance in patients' quality of life. In addition to treatment procedures, use of self-care behaviors can be considered a cost-effective and applicable method in improving the patients' symptoms. Therefore, the present study aimed to investigate the effectiveness of a self-care program in promoting self-care behaviors of patients with psoriasis. Objectives: The present study aimed to investigate the effectiveness of a self-care program in promoting self-care behaviors among patients with psoriasis. Methods: This quasi experimental, before-after study was carried out on 32 patients. The educational program was implemented face-to-face and in groups (in areas such as medicine, bathing, and clothing). The samples were examined once every 2 weeks for 3 months. Two questionnaires and 1 self-report checklist with a correlation coefficient of 92.5% were used in this study. The validity of the questionnaires was determined using content validity. Data were analyzed using repeated measures ANOVA in SPSS. Results: The patients' demographics were as follows: mean age, 42.37%; males, 16 (55.2%) and females, 13 (44.8%); married, 21 (72.4%), single, 6 (20.7%), and widowed, 2 (6.9%); secondary school education, 13 (44.8%); average disease period, 9.03%; most self-employed and housewives (9, 31%); history of disease, 7 (24.1%); and physician-diagnosed disease, 29 (100%). The results showed that the mean medication adherence rate increased from 7% to 9.72% after the intervention, and comparison of self-care behaviors before and after the intervention showed that the frequency of most behaviors significantly increased. Conclusions:The results showed that training could improve self-care behaviors. Use of simple, low-cost, and available programs for self-care behaviors is effective in reducing the patients' symptoms and improving their conditions.

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“…4 It may be explained by gender based differences of both innate and adapted immune responses in immunological diseases like psoriasis. 5 Increase in severity of psoriasis in manual labourers may be due to an increased chance of trauma and subsequent koebnerisation in manual labourers.…”

Section: Discussionmentioning

confidence: 99%

A Clinical Study on Palmar Dermatoglyphics in Psoriasis

Umesh¹,

Ashok²,

Samson³

2017

jemds

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BACKGROUNDThere is dearth of data regarding the dermatoglyphic pattern in psoriasis patients of South India. The aim is to study the palmar dermatoglyphic pattern in psoriasis and to compare it with that of a comparison group. MATERIALS AND METHODSAll consecutive psoriasis patients who attended the Department of Dermatology in Government Medical College, Thiruvananthapuram during a period of one and a half year were included in this descriptive comparative study. RESULTSThe study population comprised of 103 patients. A similar number of normal population was considered as a comparison group. In fingertip patterns, loops were the predominant pattern followed by whorls and arches in psoriasis patients. In thumb of both hands, the number of whorls were high in psoriasis patients compared to comparison group. In index finger of both hands, the number of arches were high and whorls were low when compared to comparison group. A low whorl pattern in middle finger (right and left) and a high arch pattern in left index finger were observed in psoriasis patients. A low ulnar loop pattern in left ring finger, low whorl pattern in right ring finger and a high arch pattern in both ring fingers were observed in psoriasis patients. A high number of arch patterns were observed in both little fingers. An increase in true patterns was observed in right interdigital space I. The mean total finger ridge count was high in psoriasis patients. CONCLUSIONDermatoglyphics can be used as a cost-effective tool to predict the occurrence of psoriasis in a person. Dermatoglyphic analysis can be included in examination of persons who are susceptible to psoriasis (in case of family history of psoriasis) and in psoriasis patients, due to its advantages such as easy method of taking palm prints, fast results and cost-effectiveness.

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The Higher Proportion of Men with Psoriasis Treated with Biologics May Be Explained by More Severe Disease in Men

Cited by 93 publications

References 16 publications

Effect of TNF-α inhibitors on transcriptional levels of pro-inflammatory interleukin-33 and Toll-like receptors-2 and -9 in psoriatic plaques

Effect of TNF-α inhibitors on transcriptional levels of pro-inflammatory interleukin-33 and Toll-like receptors-2 and -9 in psoriatic plaques

The Effects of a Self-Care Program on Promoting Self-Care Behaviors in Patients with Psoriasis

A Clinical Study on Palmar Dermatoglyphics in Psoriasis

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