The hippocampal–prefrontal pathway: The weak link in psychiatric disorders?

Godsil, Bill P.; Kiss, János; Spedding, Michael; Jay, Thérèse M.

doi:10.1016/j.euroneuro.2012.10.018

Cited by 387 publications

(293 citation statements)

References 188 publications

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“…54,55 Furthermore, poor fetal growth may result in impaired development of the septo-hippocampal circuit and its projections to the frontal cortex. [55][56][57] Morphological changes in the hippocampus may be responsible for impairment in hippocampal-related behaviours, such as learning and memory, 52 and may thus play a role in impaired cognitive development.…”

Section: Discussionmentioning

confidence: 99%

Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review

Murray

Fernandes

Fazel

et al. 2015

BJOG

234

149

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Background Neurodevelopmental disorders are increasingly believed to originate from intrauterine growth restriction (IUGR). Current reviews exploring the neurodevelopmental effects of IUGR, however, are mostly based on birthweight, an inadequate proxy. Objective We aimed to examine the association between IUGR documented in utero, and neurodevelopmental outcomes during childhood. Search strategy Medline, CINAHL, PsycInfo and Scopus were searched for relevant studies published after 1970. Selection criteria The analysis included studies that identified IUGR in utero, with follow‐up assessments between 1 month and 12 years of age. Data collection and analysis Data was extracted for cognitive, behavioural, language, motor, hearing, vision or sleep outcomes. Studies were summarised separately for children born at <35 and ≥35 weeks gestation. Main results Of 28 876 titles identified, 38 were suitable for inclusion. IUGR children born ≥35 weeks gestation scored on average 0.5 SD lower than non‐IUGR children across all neurodevelopmental assessments. IUGR children born <35 weeks of gestation scored approximately 0.7 SD lower than non‐IUGR children across all neurodevelopmental assessments. IUGR children with evidence of fetal circulatory redistribution (preferential perfusion of the brain) had more severe neurodevelopmental impairments than those born IUGR alone. Conclusions IUGR increases the risk of neurodevelopmental impairment during childhood differentially across domains. IUGR children born preterm or with evidence of fetal circulatory redistribution are more severely affected. Tweetable abstract IUGR is associated with an overall risk for neurodevelopmental delay in a range of neurodevelopmental domains.

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Section: Discussionmentioning

confidence: 99%

Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review

Murray

Fernandes

Fazel

et al. 2015

BJOG

234

149

View full text Add to dashboard Cite

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“…The hippocampal-prefrontal pathway appears to be necessary for successful fear regulation (Hugues and Garcia, 2007;Sotres-Bayon et al, 2012) and may be deficient in post-traumatic stress disorder (PTSD; Godsil et al, 2013). Activation of the ventromedial prefrontal cortex (vmPFC), a functional homolog of the rodent IL, correlates with successful extinction (Kalisch et al, 2006;Milad et al, 2007;Phelps et al, 2004;Soliman et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Hippocampal–Prefrontal BDNF and Memory for Fear Extinction

Rosas-Vidal

Monte

Sotres-Bayón

et al. 2014

Neuropsychopharmacol

167

168

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Infusing brain-derived neurotrophic factor (BDNF) into the infralimbic (IL) prefrontal cortex is capable of inducing extinction. Little is known, however, about the circuits mediating BDNF effects on extinction or the extent to which extinction requires BDNF in IL. Using local pharmacological infusion of BDNF protein, or an antibody against BDNF, we found that BDNF in the IL, but not prelimbic (PL) prefrontal cortex, is both necessary and sufficient for fear extinction. Furthermore, we report that BDNF in IL can induce extinction of older fear memories (14 days) as well as recent fear memories (1 day). Using immunocytochemistry, we show that BDNF is increased in the ventral hippocampus (vHPC), but not IL or PL, following extinction training. Finally, we observed that infusing BDNF into the vHPC increased the firing rate of IL, but not PL neurons in fear conditioned rats. These findings indicate that an extinction-induced increase in BDNF within the vHPC enhances excitability in IL targets, thereby supporting extinction memories.

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“…[22,23,37,38] We used three types of neural cells to fabricate microfiber-shaped neural tissues: primary mouse neural stem cells (mNSCs) dissected from the midbrain of mice (mNSC units), primary cortical cells (cortical units), and primary hippocampal cells (hippocampal units). To prepare the rod-shaped neural units in an accurate and reproducible manner, we developed a fiber-cutting device that can fix the microfiber-shaped neural tissues in a culture In the brain, 3D neural networks such as the hippocampalprefrontal pathway, [1,2] amygdala pathway, [3][4][5] and visual pathway [3,6,7] comprise various independent regions that are connected by aligned nerve fibers. [8][9][10][11] These fibers selectively connect to the target areas by passing through unrelated brain areas (Figure 1a).…”

Section: Rod-shaped Neural Units For Aligned 3d Neural Network Connecmentioning

confidence: 99%

Rod‐Shaped Neural Units for Aligned 3D Neural Network Connection

Kato-Negishi

Onoe

Ito

et al. 2017

Adv Healthcare Materials

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COMMUNICATION (1 of 7)© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Rod-Shaped Neural Units for Aligned 3D Neural Network ConnectionMidori Kato-Negishi, Hiroaki Onoe, Akane Ito, and Shoji Takeuchi* DOI: 10.1002/adhm.201700143 guidance [12,26] have also been developed as alternative means of controlling cell patterning with high cell density and/or aligned nerve fibers. However, coculturing different types of neural tissues is still difficult because culture conditions such as medium, growth factors, and extracellular matrix (ECM) differ according to the type of neural tissues. [27][28][29][30][31][32][33] Neurons also have the characteristic of axon overproduction and, consequently, axons extend over a wide area during early development. [34][35][36] Therefore, selective connectivity between specific, spatially separated neural tissues is technically difficult.This paper proposes neural tissue units with aligned nerve fibers, called "rodshaped neural units," that can connect spatially separate neural regions (Figure 1). To fabricate these units, we employ a meterlong microfiber-shaped neural tissue [22,23] as starting material, in which stem-cell-derived or primary neural cells are encapsulated and aligned within an alginate tubular hydrogel. This tissue is cut into millimeter-sized sections and, after further cell culturing, both edges of the sections bulge out and form spherical ends (Figure 1b). The proposed rod-shaped neural units have the following characteristics: (1) nerve fibers are aligned in the longitudinal direction of the rod, (2) each unit has an insulated region covered with a thin alginate hydrogel layer to prevent the encapsulated neural tissues from connecting to surrounding cells within the regions, and (3) the edges of the unit are connectable, with the spherical ends functioning as glue to connect with other neural tissues or units. In this study, we designed and fabricated the rod-shaped neural units and characterized their connectivity in terms of neuronal morphologies and network formation. In addition, we constructed a neural network from different types of neural tissues in different culture conditions, with connections to specific, spatially neural regions. Therefore, our neural units assembly can coculture different types of neural tissues with aligned nerve fibers that recapitulate the topological complexity of in vivo neural networks with high cell density and cell population.Rod-shaped neural units were prepared by cutting microfibershaped neural tissues, as reported previously. [22,23,37,38] We used three types of neural cells to fabricate microfiber-shaped neural tissues: primary mouse neural stem cells (mNSCs) dissected from the midbrain of mice (mNSC units), primary cortical cells (cortical units), and primary hippocampal cells (hippocampal units). To prepare the rod-shaped neural units in an accurate and reproducible manner, we developed a fiber-cutting device that can fix the microfiber-shaped neural tissues in a culture In the brain, 3D neural networks such as the hippoc...

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The hippocampal–prefrontal pathway: The weak link in psychiatric disorders?

Cited by 387 publications

References 188 publications

Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review

Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review

Hippocampal–Prefrontal BDNF and Memory for Fear Extinction

Rod‐Shaped Neural Units for Aligned 3D Neural Network Connection

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