The hippocampus constructs narrative memories across distant events

Cohn‐Sheehy, Brendan I.; Delarazan, Angelique I.; Reagh, Zachariah M.; Crivelli-Decker, Jordan; Kim, Kamin; Barnett, Alexander; Zacks, Jeffrey M.; Ranganath, Charan

doi:10.1016/j.cub.2021.09.013

Cited by 72 publications

(65 citation statements)

References 87 publications

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“…Patterns of hippocampal activity, including activity at event boundaries, were more similar between distant events that formed one cohesive narrative during encoding of fictional stories compared with overlapping events from unrelated narratives. One day later, the hippocampus preferentially supported detailed recall of coherent narrative events, through reinstatement of hippocampal activity patterns from encoding [92]. Remarkably, during EMDR protocol, patients may start processing an event related to a NC and then recall events that are temporally very distant and that may be related to NC but also to PC.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, it has been shown that narrative memories are constructed by the hippocampus across distant events [92]. Patterns of hippocampal activity, including activity at event boundaries, were more similar between distant events that formed one cohesive narrative during encoding of fictional stories compared with overlapping events from unrelated narratives.…”

Section: Discussionmentioning

confidence: 99%

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Randomized Trial on the Effects of a Group EMDR Intervention on Narrative Complexity and Specificity of Autobiographical Memories: A Path Analytic and Supervised Machine-Learning Study

Poli

Gemignani

Miccoli

2022

IJERPH

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Narratives of autobiographical memories may be impaired by adverse childhood experiences, generating narrative fragmentation and increased levels of perceived distress. Eye movement desensitization and reprocessing (EMDR) proved to be an effective treatment to overcome traumatic experiences and to promote coherent autobiographical narratives. However, the specific mechanisms by which EMDR promotes narrative coherence remains largely unknown. We conducted a randomized controlled pilot trial (ClinicalTrials.gov Identifier NCT05319002) in a non-clinical sample of 27 children recruited in a primary school. Participants were randomly assigned to the experimental and control groups. The experimental group underwent a three-week group EMDR intervention. Subjective unit of distress (SUD), validity of cognition (VoC), classification of autobiographical memories, narrative complexity and specificity were assessed before and after the group EMDR intervention. The group EMDR intervention was able to improve SUD and VoC scales, narrative complexity and specificity, and promoted the classification of autobiographical memories as relational. The path analysis showed that SUD was able to predict VoC and narrative specificity, which, in turn, was able to predict both narrative complexity and the classification of autobiographical memories as relational. Machine-learning analysis showed that random tree classifier outperformed all other models by achieving a 93.33% accuracy. Clinical implications are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Randomized Trial on the Effects of a Group EMDR Intervention on Narrative Complexity and Specificity of Autobiographical Memories: A Path Analytic and Supervised Machine-Learning Study

Poli

Gemignani

Miccoli

2022

IJERPH

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“…Inter-event connections may also benefit encoding. During movie watching, events highly connected with other events are more likely to reactivate and be reactivated by the other events containing shared components 43,47,48 . Consistent with this, we found that the coupling between the hippocampus and a cortical region involved in representing events (PMC 16,49 , see below) was stronger when subjects were watching events with higher semantic centrality.…”

Section: Discussionmentioning

confidence: 99%

Predicting memory from the network structure of naturalistic events

Lee

Chen

2021

Preprint

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Human life consists of a multitude of diverse and interconnected events. However, extant research has focused on how humans segment and remember discrete events from continuous input, with far less attention given to how the structure of connections between events impacts memory. We conducted an fMRI study in which subjects watched and recalled a series of realistic audiovisual narratives. By transforming narratives into networks of events, we found that more central events—those with stronger semantic or causal connections to other events—were better remembered. During encoding, central events evoked larger hippocampal event boundary responses associated with memory consolidation. During recall, high centrality predicted stronger activation in cortical areas involved in episodic recollection, and more similar neural representations across individuals. Together, these results suggest that when humans encode and retrieve complex real-world experiences, the reliability and accessibility of memory representations is shaped by their location within a network of events.

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“…The method of the HeNReG is based on the presupposition that creating a mental landscape of what is considered true by participants, in relation to what they value with respect to health, is the optimal way to construct a robust narrative [59]. The reason for this assumption is that narratives are formed and accessed in the hippocampus [60]. As such, this stops the creation of memories resulting from fear created in the amygdala or traumatic memory formation in the hippocampus elicited from burnout [61].…”

Section: Analysis Of the Methodsmentioning

confidence: 99%

Enhancing Hopeful Resilience Regarding Depression and Anxiety with a Narrative Method of Ordering Memory Effective in Researchers Experiencing Burnout

Nash

2022

Challenges

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Depression and anxiety are prevalent, persistent, and difficult to treat industrialized world mental health problems that negatively modify an individual’s life perspective through brain function imbalances—notably, in the amygdala and hippocampus. Primarily treated with pharmaceuticals and psychotherapy, the number of individuals affected plus the intensity of their suffering continues to rise post-COVID-19. Decreasing depression and anxiety is a major societal objective. An approach is investigated that considers depression and anxiety consequences of the particular method people adopt in ordering their memories. It focuses on narrative development and the acceptance of different perspectives as uniquely necessary in creating safe protection from research burnout. The method encourages thoughtful reconsideration by participants of the negative assessments of their circumstances that can lead to depression and anxiety. The aim is to determine if the method of ordering developed is helpful in reducing burnout. This is considered through inspecting and comparing group members’ feedback form results, both pre- and post-COVID-19 restrictions. The method found useful to participants in reducing research burnout through developing hopeful resilience is comparable to authentic leadership. The conclusions offered encourage psychological and neurological research with respect to this method of promoting hopeful resilience for burnout to diminish depression and anxiety.

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The hippocampus constructs narrative memories across distant events

Cited by 72 publications

References 87 publications

Randomized Trial on the Effects of a Group EMDR Intervention on Narrative Complexity and Specificity of Autobiographical Memories: A Path Analytic and Supervised Machine-Learning Study

Randomized Trial on the Effects of a Group EMDR Intervention on Narrative Complexity and Specificity of Autobiographical Memories: A Path Analytic and Supervised Machine-Learning Study

Predicting memory from the network structure of naturalistic events

Enhancing Hopeful Resilience Regarding Depression and Anxiety with a Narrative Method of Ordering Memory Effective in Researchers Experiencing Burnout

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