The hippocampus plays a role in the recognition of visual scenes presented at behaviorally relevant points in time: Evidence from amnestic mild cognitive impairment (aMCI) and healthy controls

Szamosi, András; Levy-Gigi, Einat; Kelemen, Ogúz; Kéri, Szabolcs

doi:10.1016/j.cortex.2012.11.001

Cited by 10 publications

(18 citation statements)

References 49 publications

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“…Previous studies have clearly demonstrated that schizophrenia is characterized by severe deficits in the ability to combine contextual information together to form a coherent memory of an event (the context-memory deficit hypoth esis: Diaz-Asper, Malley, Genderson, Apud, & Elvevag, 2008;Rizzo, Danion, Van der Linden, Grange, & Rohmer, 1996). Fur thermore, Szamosi, Levy-Gigi, Kelemen, and Keri (2013) found significant positive correlations between total hippocampal vol ume and the recognition of scenes encoded with targets in patients with amnestic mild cognitive impairment, whereas no correlation was found with the recognition of scenes encoded with distractors. Overall, these data suggest that the hippocampus plays an impor tant role in the formation of memory traces of the visual environ ment when people concurrently perform a primary detection task, and that its involvement is selective for stimuli temporally asso ciated with relevant targets.…”

Section: Discussionmentioning

confidence: 95%

The attentional boost effect in schizophrenia.

Rossi-Arnaud¹,

Spataro²,

Saraulli³

et al. 2014

Journal of Abnormal Psychology

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The present study reports 2 experiments examining the Attentional Boost Effect (ABE) in schizophrenic patients and matched healthy controls, using visual and verbal materials. The ABE refers to the surprising finding that, in a divided attention condition, images and words encoded with targets are remembered better than images and words encoded with distractors. Unlike controls (who showed the typical ABE), schizophrenic patients reported no memory advantage for stimuli presented together with targets in the divided attention condition. On the other hand, the interference effect on the recognition of stimuli presented with distractors was not exacerbated in patients (as compared with controls). In line with the dual-task interaction model proposed by Swallow and Jiang (2013), the absence of a significant facilitation indicates that schizophrenic patients have a deficit in the process of attentional enhancement triggered by target detection. A number of neural mechanisms potentially underlying this impairment are discussed, as well as implications for the characterization of the attentional deficits involved in schizophrenia.

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Section: Discussionmentioning

confidence: 95%

The attentional boost effect in schizophrenia.

Rossi-Arnaud¹,

Spataro²,

Saraulli³

et al. 2014

Journal of Abnormal Psychology

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“…Most often, learning skills and the ability to recall new information are affected to the highest extent. Brain imaging research shows dysfunction in the medial temporal lobe (MTL), including the hippocampal formation in MCI (Jack et al, 1997; Dickerson and Sperling, 2008; Nickl-Jockschat et al, 2012; Szamosi et al, 2013) but other areas might also be affected (Rombouts et al, 2009). Memory tests have established that certain forms of explicit memory and learning, such as delayed recall and list learning, decline in MCI (Petersen et al, 1999; Grundman et al, 2004; Leube et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Probabilistic sequence learning in mild cognitive impairment

Németh¹,

Janacsek²,

Király³

et al. 2013

Front. Hum. Neurosci.

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Mild Cognitive Impairment (MCI) causes slight but noticeable disruption in cognitive systems, primarily executive and memory functions. However, it is not clear if the development of sequence learning is affected by an impaired cognitive system and, if so, how. The goal of our study was to investigate the development of probabilistic sequence learning, from the initial acquisition to consolidation, in MCI and healthy elderly control groups. We used the Alternating Serial Reaction Time task (ASRT) to measure probabilistic sequence learning. Individuals with MCI showed weaker learning performance than the healthy elderly group. However, using the reaction times only from the second half of each learning block—after the reactivation phase—we found intact learning in MCI. Based on the assumption that the first part of each learning block is related to reactivation/recall processes, we suggest that these processes are affected in MCI. The 24-h offline period showed no effect on sequence-specific learning in either group but did on general skill learning: the healthy elderly group showed offline improvement in general reaction times while individuals with MCI did not. Our findings deepen our understanding regarding the underlying mechanisms and time course of sequence acquisition and consolidation.

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“…() provided evidence that responding to target stimuli at behaviorally relevant points of time enhanced activity in early visual cortical areas, but it is not clear how it affects memory for contextual background images. Although our current results and data from individuals with hippocampal atrophy (Szamosi et al ., ) suggest the relevance of midbrain dopaminergic–hippocampal interactions in attentional boost (Shohamy & Wagner, ; Wimmer et al ., ), this hypothesis should be directly tested.…”

Section: Discussionmentioning

confidence: 99%

“…Stimuli were presented on a VP2765-LED-27″ monitor (ViewSonic, Walnut, CA, USA; refresh rate: 60 Hz, resolution: 1920 9 1080 pixel; viewing distance: 50 cm; output luminance: 65 cd/m 2 ) controlled by a personal computer (Dell XPS workstation). We used photographs of natural and urban scenes (size: 28º of visual angle), as described previously Szamosi et al, 2013).…”

Section: Attentional Boost Test (Abt)mentioning

confidence: 99%

“…This reward might 'widen the window of attention' facilitating the encoding of the background scene. The hippocampal formation may play a pivotal role in this encoding process because individuals with hippocampal atrophy had weak attentional boost (Szamosi et al, 2013). Shohamy & Wagner (2008) showed that the interaction between midbrain dopaminergic centers (ventral tegmental area/substantia nigra) and the hippocampal formation is essential for associative encoding (see also Wimmer et al, 2012).…”

Section: Mechanisms Of Attentional Boostmentioning

confidence: 99%

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How attentional boost interacts with reward: the effect of dopaminergic medications in Parkinson's disease

Kéri

Nagy

Levy-Gigi

et al. 2013

Eur J of Neuroscience

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There is widespread evidence that dopamine is implicated in the regulation of reward and salience. However, it is less known how these processes interact with attention and recognition memory. To explore this question, we used the attentional boost test in patients with Parkinson's disease (PD) before and after the administration of dopaminergic medications. Participants performed a visual letter detection task (remembering rewarded target letters and ignoring distractor letters) while also viewing a series of photos of natural and urban scenes in the background of the letters. The aim of the game was to retrieve the target letter after each trial and to win as much virtual money as possible. The recognition of background scenes was not rewarded. We enrolled 26 drug-na€ ıve, newly diagnosed patients with PD and 25 healthy controls who were evaluated at baseline and follow-up. Patients with PD received dopamine agonists (pramipexole, ropinirole, rotigotine) during the 12-week follow-up period. At baseline, we found intact attentional boost in patients with PD: they were able to recognize target-associated scenes similarly to controls. At follow-up, patients with PD outperformed controls for both target-and distractor-associated scenes, but not when scenes were presented without letters. The alerting, orienting and executive components of attention were intact in PD. Enhanced attentional boost was replicated in a smaller group of patients with PD (n = 15) receiving L-3,4-dihydroxyphenylalanine (L-DOPA). These results suggest that dopaminergic medications facilitate attentional boost for background information regardless of whether the central task (letter detection) is rewarded or not.

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The hippocampus plays a role in the recognition of visual scenes presented at behaviorally relevant points in time: Evidence from amnestic mild cognitive impairment (aMCI) and healthy controls

Cited by 10 publications

References 49 publications

The attentional boost effect in schizophrenia.

The attentional boost effect in schizophrenia.

Probabilistic sequence learning in mild cognitive impairment

How attentional boost interacts with reward: the effect of dopaminergic medications in Parkinson's disease

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