The hippuric acid test for hepatic function; its relation to other tests in general use

Snell, Albert M.; Plunkett, John

doi:10.1007/bf03002434

Cited by 23 publications

(2 citation statements)

References 9 publications

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“…In uncomplicated cholecystitis the test is normal, suggesting the absence of serious intrahepatic damage. Vaccaro (13) and Snell & Plunkett (14) have corroborated these findings and have found a reasonable agreement between the test and the degree of pathology morphologically observed in the liver. Kohlstaedt & Helmer ( 15) likewise found the synthesis of hippuric acid lowered in patients with damaged livers.…”

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confidence: 65%

Detoxication Mechanisms

Quick¹

1937

Annu. Rev. Biochem.

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From the trend of the current biological literature, one can discern the beginning of a realization that the so�called detoxication mecha nisms are not isolated biochemical curiosities, but probably constitute vital processes in the body economy. An attempt will therefore be made in this review to interpret the various results, often of highly divergent types of research, as contributions aiding in the solution of more or less concise and circumscribed physiological problems, rather than merely listing results under the well�known and estab� lished headings.

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supporting

confidence: 65%

Detoxication Mechanisms

Quick¹

1937

Annu. Rev. Biochem.

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“…[61][62][63] The recognition of different classes and etiologies of liver disease, their influence on patient morbidity and mortality, and the development of medical and surgical therapies demanded the introduction of techniques not only for diagnosis but also for assessment of disease severity, as judged by the impairment of overall liver performance and ultimately its impact on prognosis. The early decades of the 20th century witnessed the development of a serum bilirubin test, 64 utilization of Bauer's 1906 galactose test, 65 hippuric acid synthesis assays 66 based on the research of Armand J. Quick (of Quick Test fame 67 ), and tests based on the disposal by the body of a rainbow of dyes: indigo carmine, Congo red, methylene blue, Evans blue, Rose Bengal, indocyanine green (ICG), and arguably the most popular, the nowobsolete bromsulphalein (BSP) that is gloriously purple in alkaline solution.…”

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confidence: 99%