The histamine-diamine oxidase system and mucosal proliferation under the influence of aminoguanidine and seventy percent resection of the rat small intestine

Mennigen, Rudolf; Biegański, Tadeusz; Elbers, A.; Kusche, Jürgen

doi:10.1007/bf02222245

Cited by 15 publications

(6 citation statements)

References 6 publications

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“…Dowling [91] postulated that during the adaptive response the mucosal DAO activity would drop to permit and/or facilitate intesti nal growth. However, results from several studies indicated that not only does ODC activity rise during adaptive hyperplasia, but that DAO activity also increases in parallel to ODC [92], Rokkas et al [93] found that inhi bition of DAO, by administering aminoguanidine subcutaneously (25 mg/kg/day), en hanced adaptive intestinal mucosal growth af ter 80% proximal small-bowel resection. This observation suggests that following extensive resection the structural and functional adaptive response of the remaining intestine may be enhanced by blocking of DAO activi ty.…”

Section: Alterations In Key Regulators O F Polyamine Levelsmentioning

confidence: 99%

Towards Understanding the Process of Intestinal Adaptation

Wolvekamp

Heineman

Taylor

et al. 1996

Dig Dis

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When bowel is lost due to disease or surgery, the residual bowel increases its functional capacity in order to compensate for the loss of absorptive capacity. The success and extent of this adaptive process is critical to recovery. This article reviews the current understanding of the intestinal adaptation. Adaptation is a complex process which as yet is poorly understood and thus it is difficult to develop strategies to enhance the outcome of the adaptation phase. Extensive loss of bowel brings about functional as well as morphologic changes in the remaining intestine. The exact relationship between histologic changes and function is still unknown and some studies show that histologic changes may precede functional changes. Both nonnutritive and nutritive factors have been identified as major stimuli to the adaptive process. The importance of oral intake as a positive stimulus has been demonstrated and the role of diet composition rather than diet complexity being recognized. Recent studies attempt to understand the molecular basis of intestinal adaptation by seeking to characterize the nature of humoral factors involved and to establish alterations in the patterns of gene expression. These new approaches may facilitate the identification of both nutritional and pharmacological methods to manipulate the intestinal adaptation process.

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Section: Alterations In Key Regulators O F Polyamine Levelsmentioning

confidence: 99%

Towards Understanding the Process of Intestinal Adaptation

Wolvekamp

Heineman

Taylor

et al. 1996

Dig Dis

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“…Dowling [49] described that it was suspected that dur ing the adaptive response mucosal DAO ac tivity would fall to permit and/or facilitate intestinal growth. However, results from sev eral studies demonstrated that ODC activity does not only rise during adaptive hyperpla sia, but that DAO activity rises parallel to ODC [50]. The speculative actions of ODC and DAO in the mucosal growth regulation process is schematically outlined in figure 2.…”

Section: Role Of Dao In Mucosal Growth Regulationmentioning

confidence: 99%

Diamine Oxidase: An Overview of Historical, Biochemical and Functional Aspects

Wolvekamp

Bruin²

1994

Dig Dis

160

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This article is a review of the historical, biochemical, and functional aspects of the enzyme diamine oxidase (DAO). The amine oxidase DAO, formerly called histaminase, is found in various tissues, but is especially active in the intestinal mucosa. Its function is the oxidative deaminating of several polyamines, essential substances for cell proliferation. DAO is thus a regulating enzyme in rapidly proliferating tissues such a bone marrow and intestinal mucosa. Results from several studies have demonstrated that both ornithine decarboxylase (ODC) and DAO activity rise during adaptive hyperplasia seen after small bowel resection. The ODC-dependent increase in polyamine content and subsequent increase in cell proliferative activity is probably downregulated locally in the villus tip by the increased DAO activity. DAO is normally present in very small amounts in the circulation and its basal plasma levels are positively correlated with the maturity and integrity of the intestinal mucosa. After intravenous administration of heparin, DAO is released from its capillary binding sites in the lamina propria into the peripheral circulation. Measurement of postheparin DAO release enhances its sensitivity and is now extensively studied to assess its value as follow-up or screening test for several enteropathies. Measuring basal as well as postheparin DAO levels has potential relevance following small bowel transplantation. Rejection of the small bowel graft leads to mucosal damage, which could conceivably lead to changes in DAO activity.

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“…We also focused on DAO activity, which is considered to be an index of SIM condition. DAO is a polyamine-degrading enzyme localized in the small intestine and placenta, and controls growth of SIM in which cell turnovers are very rapid (12,13). A correlation between DAO activity levels in small intestinal tissue and the blood has been reported, based on which it is considered that the SIM condition can be objectively measured by serum DAO activity (14).…”

Section: Discussionmentioning

confidence: 99%

Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model

et al. 2014

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Supportive therapy during chemotherapy has become essential, but effective preventive therapies to gastrointestinal mucosal injury are few. We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model. In this study, we used twenty male SD rats. They were divided into control, 5-fluorouracil (5-FU) (orally administered at 20 mg/kg day), 5-FU+glutamine (1000 mg/kg/day) and 5-FU+glutamine+fiber and oligosaccharide (GFO(®)) (1000 mg/kg/day) groups. All groups were sacrificed on day 6 and upper jejunums were excised. The jejunal villous height was measured in specimens. IgA level in jejunal washing solution, and serum diamine oxidase activity were also measured. The jejunal villous height was recognized as shorter in the specimen from 5-FU treated rats compared with 5-FU+glutamine treated rats (p<0.001). Serum diamine oxidase activity in 5-FU+glutamine group were significantly superior to that in 5-FU group (p=0.028). IgA level in jejunal washing solution tended to be higher in 5-FU+glutamine group than that in 5-FU group (p=0.076). On the other hand, serum diamine oxidase activity and IgA level in jejunal washing solution showed no significant difference between 5-FU+GFO and 5-FU treatment group. Our results suggest that glutamine showed protective effects on mucosal injury of small intestine in rat anticancer drug-induced enteritis model.

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The histamine-diamine oxidase system and mucosal proliferation under the influence of aminoguanidine and seventy percent resection of the rat small intestine

Cited by 15 publications

References 6 publications

Towards Understanding the Process of Intestinal Adaptation

Towards Understanding the Process of Intestinal Adaptation

Diamine Oxidase: An Overview of Historical, Biochemical and Functional Aspects

Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model

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