The Histamine H3 Receptor

Coruzzi, Gabriella; Poli, E.; Morini, Giuseppina; Bertaccini, G.

doi:10.1007/978-1-59259-202-9_9

Cited by 11 publications

(6 citation statements)

References 69 publications

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“…The major role of histamine and of H 2 Rs in the stomach is the regulation of acid secretion by the parietal (39,40,43,55); however, functional data were dependent on the species and the experimental assay (40,44,46). The negative regulation of histamine release from ECL cells has been proposed by several authors as the main function mediated by H 3 Rs in the rat stomach (33,43).…”

Section: Gastric Acid Secretionmentioning

confidence: 99%

“…As opposed to the key role played by histamine in the regulation of parietal cell function, its role in gastric mucosal defense has long been debated, since H 1 R or H 2 R selective ligands displayed either ulcerogenic or protective effects (44). The discovery of histamine H 3 Rs and the use of (R)-alpha-methylhistamine and thioperamide have highlighted the protective effect of histamine in the gastric mucosa, since H 3 R activation prevented the acute mucosal damage induced in rats by absolute ethanol, non-steroidal anti-inflammatory drugs, ammonia, concentrated HCl or stress (78)(79)(80)(81)(82)(83).…”

Section: Gastric Mucosal Defensementioning

confidence: 99%

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Role of histamine H4 receptors in the gastrointestinal tract

Coruzzi¹

2012

Front Biosci

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Section: Gastric Acid Secretionmentioning

confidence: 99%

Section: Gastric Mucosal Defensementioning

confidence: 99%

Role of histamine H4 receptors in the gastrointestinal tract

Coruzzi¹

2012

Front Biosci

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“…In the gastrointestinal tract H 3 receptors are located in cholinergic and non-adrenergic non-cholinergic (NANC) neurons of the myenteric plexus, in endocrine and/or paracrine cells of the gastric mucosa and, at least in rabbits, also in parietal cells (51). H 3 receptors are mainly located on histamine-producing cells, where they work as an endogenous inhibitory mechanism operated by histamine itself to control excess acid production.…”

Section: Presynaptic Modulation In Autonomic Nervous Systemmentioning

confidence: 99%

Histamine and its Effects Mediated via H3 Receptor – Potential Clinical Applications of H3 Antagonists

Hanuskova¹,

Plevková²

2013

Acta Medica Martiniana

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A b s t r a c tHistamine is one of the most important biogenic amines and it mediates numbers of physiological processes. It is also involved in majority of inflammatory diseases via its receptors H 1 , H 2 , H 3 and H 4 . The role of histamine had been recognized as substantial in many allergic diseases including bronchial asthma, thus the histamine receptor antagonists (H 1 ) are frequently used in the clinical practice as potent anti-allergic and anti-inflammatory drugs.However, first generation of antihistamines have also adverse effects, predominantly sedation, changes in appetite and many more, and they are still not fully effective in all patients. Attention is now focused mainly on H 3 and H 4 receptor antagonists and their potential clinical applications. This review focuses basically on the H 3 receptor, its expression pattern and some effects which are mediated by H 3 , discussing its clinical relevance.

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“…These agents have been shown to be able to inhibit acid secretion in animal models [58] and may become a treatment for GER in the future [57]. …”

Section: Treatment Of Germentioning

confidence: 99%

Gastroesophageal Reflux in Critically Ill Children: A Review

Solana

Cid

Sánchez

2013

ISRN Gastroenterology

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Gastroesophageal reflux (GER) is very common in children due to immaturity of the antireflux barrier. In critically ill patients there is also a high incidence due to a partial or complete loss of pressure of the lower esophageal sphincter though other factors, such as the use of nasogastric tubes, treatment with adrenergic agonists, bronchodilators, or opiates and mechanical ventilation, can further increase the risk of GER. Vomiting and regurgitation are the most common manifestations in infants and are considered pathological when they have repercussions on the nutritional status. In critically ill children, damage to the esophageal mucosa predisposes to digestive tract hemorrhage and nosocomial pneumonia secondary to repeated microaspiration. GER is mainly alkaline in children, as is also the case in critically ill pediatric patients. pH-metry combined with multichannel intraluminal impedance is therefore the technique of choice for diagnosis. The proton pump inhibitors are the drugs of choice for the treatment of GER because they have a greater effect, longer duration of action, and a good safety profile.

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The Histamine H3 Receptor

Cited by 11 publications

References 69 publications

Role of histamine H4 receptors in the gastrointestinal tract

Role of histamine H4 receptors in the gastrointestinal tract

Histamine and its Effects Mediated via H3 Receptor – Potential Clinical Applications of H3 Antagonists

Gastroesophageal Reflux in Critically Ill Children: A Review

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