The Histocompatibility Complex SL‐A in the Pig. Possible Recombination Between the Regions Governing MLR and Serology Respectively

Abstract

The present study concerns a family of pigs genotypically defined for the SL-A system (major histocompatibility system in this species). One of this siblings showed evidence of a dissociation between serological and MLC characteristics. A thorough study of this case suggested different but linked loci for the SL-A antigens as serologically defined at present and for the MLC respectively. Furthermore, one-way MLC revealed a stimulation of heterozygous by homozygous cells for the SL-A system.

Serologically defined specificities of the pig main histocompatibility complex (SL‐A)

“…They also confirmed the association between classic, serologically determinable products (SD products) and the degree of blastic transformation of allogenic lymphocytes in a mixed culture (MLC) for which lymphocyte-defined (LD) products are responsible (Vaiman et al, 1970b;White et al, 1973;Sachs et al, 1976). In addition, recombination between the genes controlling SD and LD products was described (Vaiman et al, 1973), SL-A linkage to the J blood group locus was detected (Hruban et al,19'761, serum specific SL-A inhibitors were found (Cwik & Schmid, 1975) and the existence of B lymphocytic alloantigens controlled from a region responsible for blastic transformation in a MLC was described (Vaiman et al, 1975).…”

Presence of soluble SLA histocompatibility antigen in pig plasma

“…The major histocompatibility complex SLA of the pig, like the H2 complex of the mouse and human HLA, is composed of an as yet unknown number of closely linked genes (Vaiman et al, 1970(Vaiman et al, , 1973. One or several genes are directly involved in the control of the mixed lymphocyte reaction (Vaiman et al, 1970), whereas others code for the usual serologically defined antigens, the so-called SD series (Vaiman, 1973;Vaiman et al, 1972). Some evidence exists that 3 distinct SD series exist for SLA (manuscript in preparation).…”

Histocompatibility studies in pigs from outbred and semi‐inbred families

“…Like other species, the pig was found to have a main histocompatibility system (MHS) of serologically detectable antigens (by lymphocytotoxic test) known as PL-A (Viza et al, 1970;White et al, 1973) or SL-A (Vaiman et al, 1970b). An association was found between reactivity in mixed lymphocyte cultures (MLR) and the serologically defined SL-A (PLA) products (Vaiman et al, 1970a;White et al, 1973) and evidence of recombination of the two corresponding chromosomal regions was submitted (Vaiman et al, 1973).…”