The Histologic Structure of the Human Pineal Body

Scharenberg, Katja; Liss, Leopold

doi:10.1016/s0079-6123(08)63452-4

Cited by 60 publications

(23 citation statements)

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“…Continued deposition of calcium salts and synthesis of the organic matrix by the pinealocyte could result in the growth of inclusions with the observed lamellar or concentric structure. This type of lamellar structure is also characteristic of human pineal concretions [E a rle, 1965;Scharenberg and Liss, 1965;Tapp and Huxley, 1972]. During the process of growth and inclusion formation, adjacent pineaiocytcs may fuse and thus give rise to the apparent 'spaces' or cavities of the size of two or more pinealocytes sometimes observed, with or without inclusions within them, especially in the older animals.…”

Section: Development O F Calcified Inclusionsmentioning

confidence: 91%

Calcified inclusions in the superficial pineal gland of the mongolian gerbil, Meriones unguiculatus

Japha¹,

Eder²,

Goldsmith³

1976

Cells Tissues Organs

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A histological and histochemical study of the pineal gland of neonatal, juvenile and adult gerbils is described. Calcified inclusions appear within pinealocytes in the superficial pineal about the third week of age, and the incidence of inclusions increases with age until, by the eleventh week, they are found in all animals. The inclusions contain an organic matrix composed of a carbohydrate, probably an acid mucopolysaccharide, complexed to protein. Calcification does not occur in the deep pineal. The data are interpreted to indicate that the formation of calcified inclusions is a normal process within the gerbil pineal. The similarity of the process of calcification in the gerbil and in the human pineal suggests that the gerbil may be the animal of choice for the controlled study of the phenomenon of pineal calcification.

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Section: Development O F Calcified Inclusionsmentioning

confidence: 91%

Calcified inclusions in the superficial pineal gland of the mongolian gerbil, Meriones unguiculatus

Japha¹,

Eder²,

Goldsmith³

1976

Cells Tissues Organs

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“…The cytological analysis of this neoplasm by light microscopy indicates a strong resemblance to normal eytomorphology and architectonic arrangement of the pineal body [18,19]. This tumor also tended to form cellular islands similar to those found in the normal human pineal.…”

Section: Discussionmentioning

confidence: 91%

Electron microscopic study of an ectopic pinealoma

1967

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Summary.A specimen from a patient with an ectopic pinealoma located in the third ventricle was investigated by light and electron microscopy.The study has demonstrated many small membrane-limited electron-dense granules in the pinea]ocyte-like principal tumor cells. They were similar to those found in the normal pineal body of mammals and probably represent granules of biogenic amines.The literature of biochemical studies on the secretion of the pineal body and the pinealoma was reviewed as supportive evidence of our ultrastructural findings.Zusammen/assung. Eine Gewebsprobe aus eincm ektopischen Pinealom des 3. Ventrikels wurde licht-und elektronenmikroskopisch untersucht. In den Pinealocyten-~hnlichen Hauptzellen des Tumors wurden viele kleine membranbegrenzte elektronendichte Granula nachgewiesen. Sie waren tLhnlich denen in normalen Pblealiszellen der S~uger und entspreehen wahrscheinlich Granu]a biogener Amine. _&us der Literatur fiber biochemische Untersuchungen fiber die Sekretion der Pinealis und des Pinealoms ergeben sich unterstfitzendc Argumente zu der Deutung der eigenen ultrastrukturellen Befunde.

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“…The principal cell is the pineal parenchymal cell or pineocyte, which is surrounded by a stroma of fibrillary astrocytes admixed with sympathetic neurons [16-18]. The presence of glial cells in the pineal gland was first demonstrated by impregnation techniques with gold chloride-sublimate [15,19]. Later Papasozomenos et al established the presence of glial fibrillary acidic (GFA) protein-containing cells in the human pineal gland, suggesting the significance of astrocytic participation in the structure of human pineal gland throughout life [6,10].…”

Section: Discussionmentioning

confidence: 99%

Low-grade oligodendroglioma of the pineal gland: a case report and review of the literature

et al. 2010

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BackgroundGliomas are a very rare subtype of pineal region tumours, whereas oligodendrogliomas of the pineal region are exceedingly rare, since there have been only 3 cases of anaplastic oligodedrogliomas reported this far.Methods-ResultsWe present a case of a low-grade oligodendroglioma arising in the pineal gland of a 37 year-old woman. The patient presented with diplopia associated with a cystic pineal region mass demonstrated on MRI. Total resection was performed and histological examination showed that the cystic wall consisted of tumour cells with a central nucleus a perinuclear halo and minimal pleomorphism. Immnunohistochemical analysis showed that these cells were diffusely positive for CD57, and negative for GFAP, CD10, CD99, cytokeratins, neurofilaments and synaptophysin. FISH analysis was performed in a small number of neoplastic cells, which were not exhausted after immunohistochemistry and did not reveal deletion of 1p and 19q chromosome arms. However, the diagnosis of a low grade oligodendroglioma of the pineal gland was assigned.ConclusionAlthough the spectrum of tumours arising in the pineal gland is broad, the reports of oligodendrogliomas confined to this location are exceedingly rare, and to the best of our knowledge there is no report of a low-grade oligodendroglioma. However, they should be added in the long list of tumours arising in the pineal gland.

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The Histologic Structure of the Human Pineal Body

Cited by 60 publications

References 0 publications

Calcified inclusions in the superficial pineal gland of the mongolian gerbil<i>, Meriones unguiculatu</i><i>s</i>

Calcified inclusions in the superficial pineal gland of the mongolian gerbil<i>, Meriones unguiculatu</i><i>s</i>

Electron microscopic study of an ectopic pinealoma

Low-grade oligodendroglioma of the pineal gland: a case report and review of the literature

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