The Histological Classification of Early Gastric Cancer (Micro‐invasive Carcinoma of the Stomach)

Acta Pathologica Microbiologica Scandinavica Series A :Patholog

Ohman

1982

Self Cite

Gastrectomy specimens from 51 patients operated on because of peptic ulcer disease were searched histologically for the presence of intramucosal cysts. The number of cysts for each cm of mucosa analyzed (cystic index) was calculated. Intramucosal cysts occurred in 34 per cent of the patients. The resultant cystic index was 0.19 (S.D. ± 0.40). The cystic index was not correlated to age or sex. Comparative studies demonstrated significantly higher (p<0.001) proportions of intramucosal cysts in the non‐tumoral mucosa from patients with early gastric cancer (cystic index 3.13 – S.D. ± 3.55). The possible association between benign intramucosal cystic dilatation of the gastric glands and the occurrence of gastric carcinoma deserves further investigation. The occurrence of intramucosal cysts in a biopsy specimen should intensify the search for an early gastric cancer.

mentioning

confidence: 97%

“…Owing to the common Occurrence of intramucosal gastric cysts in Swedish patients with early gastric cancer (7), it was considered pertinent to investigate the frequency of intramucosal cysts in Swedish subjects with no carcinoma. The results are reported here.…”

mentioning

confidence: 99%

The Intramucosal Cysts of the Stomach

Acta Pathologica Microbiologica Scandinavica Series A :Patholog

Ohman

1982

Self Cite

Atypical Mitosis in Gastric Intestinal Metaplasia in Japanese Patients

Japanese Journal of Cancer Research

Kato

Kitagawa

1993

The characteristics of the mitotic figures occurring in intestinal metaplasia of the gastric mucosa were investigated in 50 consecutive gastrectomy specimens. The specimens contained, in addition, early gastric cancer of intestinal type (n = 38) or of diffuse type (n = 12). One hundred or more consecutive mitoses/specimen were studied by high‐power microscopy (× 1000). Of the 5,140 mitoses, 1,030 (i.e. 20.0%, range 8–34%) were considered as atypical according to a previous classification. The presence of atypical mitosis was not influenced by the gender or age of the patient, or the histological type of the tumor present in the specimen. Studies of gastrectomy specimens from Swedish patients with early gastric cancer showed a much lower frequency of mitotic figures/specimen and occasional atypical mitosis. The high frequency of atypical mitosis in intestinal metaplasia in the gastric mucosa of Japanese nationals may mirror a profound genetic instability in that mucosa, and suggests that intestinal metaplasia with atypical mitosis may be a precancerous lesion in the Japanese.

Frequency of Atypical Mitosis in Intestinal Metaplasia of the Gastric Mucosa in Japanese Patients

Japanese Journal of Cancer Research

Kato

Kitagawa

1994

The morphologic characteristics of the mitotic figures present in intestinal metaplasia (IM) of the gastric mucosa were investigated in 70 concecutive gastrectomy specimens from Japanese nationals. The specimens contained, in addition, early gastric cancer of intestinal type (n=44) or of diffuse type (n=22). The remaining 4 were recorded as mixed. One hundred or more consecutive mitoses/specimens were studied by high‐power microscopy in hematoxylin and eosin‐stained preparations (at × 1000). A total of 7259 mitoses were recorded (mean 103.7 mitoses/case). Of these, 1089 mitoses (i.e. 19.1%) were considered as atypical according to a previous classification. The percentage of atypical mitoses was found to be unrelated to the gender, to the increasing age of the patients, to the histologic type of the adenocarcinoma contained in the specimens, or to the anatomic site (e.g. corpus or antrum or tumor proximity). Comparative studies were done with gastrectomy specimens from Swedish nationals (a population with a 4‐times‐lower incidence of gastric carcinoma than the Japanese). The results showed a much lower frequency of mitotic figures/specimen and only occasional atypical mitosis. Since atypical mitosis has so far been reported only for neoplastic lesions in the gastrointestinal tract, it is suggested that IM with atypical mitosis may be a genuine precancerous lesion in the gastric mucosa in Japanese subjects.