The Histological Mechanisms of Hair Loss

Abstract

The growing hair resists pulling out of the skin in particular site, where the keratinization of hair cortex and hair cuticle cells as well as the cells of the hair inner root sheath (IS) (being in tight contact) are advanced enough to make them rather strong but lower the level where the hair separates from the hair inner root sheath. The hair which does not grow is kept for some time within the skin by the direct contact of the keratinized hair cortex cells with the cells of the hair outer root sheath. Such contact is absent at the phase of growing hair and even in the case of proliferation inhibition in the follicle bulb causing the lack of hair resistance to pulling it out of the skin several days after inhibition induction.

Platelet Rich Plasma Hybridized Adipose Transplant (PHAT) for the Treatment of Hair Loss: A Case Series

“…There are known differences between female [9][10][11][12] and male pattern baldness [13][14][15], but the histological mechanisms are the same [8,16]. The key contributor to androgenic alopecia is dihydrotestosterone (DHT) which drives miniaturization of the hair follicle until it can no longer breach the surface of the scalp [17].…”

“…where the scalp must be optimized for follicle survival [10,17,37,38]. Among other things, the scalp is critical for temperature regulation [16,28,39], nutrient delivery, angiogenic and blood flow support and hormonal support of the follicle [7,16,28,37,38,40]. Scalp biopsy often provides a window into the causes of alopecia [10] and age-related changes in the scalp dermal sheath and dermal fibroblasts impact hair aging [7,37].…”