The histological prevalence and clinical implications of folliculotropism and syringotropism in mycosis fungoides

Hossain, Claudia; Jennings, Tara; Duffy, Robert; Knoblauch, Kelly; Gochoco, Ashley; Chervoneva, Inna; Shi, Wenyin; Alpdogan, Seyfettin Onder; Porcu, Pierluigi; Pro, Barbara; Sahu, Joya

doi:10.21037/cco.2018.10.02

Cited by 11 publications

(12 citation statements)

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“…Mycosis fungoides is one of the most common types of Cutaneous T Cell Lymphomas (CTCL). MF originates in the peripheral epidermotropic T cells, in specific in the memory T cells (CD45RO+), expressing the T cell receptor (TCR) and CD4+ immunophenotype [ 35 ]. Vaidya et al in their 2022 publication showed that MF has an incidence of six cases per million per year in the United States and Europe.…”

Section: Discussionmentioning

confidence: 99%

Novel Theranostic Approaches Targeting CCR4-Receptor, Current Status and Translational Prospectives: A Systematic Review

et al. 2023

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Background: With the high mortality rate of malignant tumors, there is a need to find novel theranostic approaches to provide an early diagnosis and targeted therapy. The chemokine receptor 4 (CCR4) is highly expressed in various tumors and plays an important role in tumor pathogenesis. This systematic review aims to provide a complete overview on clinical and preclinical applications of the CCR4 receptor as a target for theranostics, using a systematic approach to classify and assemble published studies performed on humans and animals, sorted by field of application and specific tumor. Methods: A systematic literature search of articles suiting the inclusion criteria was conducted on Pubmed, Scopus, Central, and Web of Science databases, including papers published from January 2006 to November 2022. Eligible studies had to be performed on humans and/or in vivo/in vitro studying CCR4 expression in tumors. The methodological quality was assessed through the Critical Appraisal Skills Programme (CASP) assessing only the studies performed on humans. Results: A total of 17 articles were screened. The articles were assessed for eligibility with the exclusion of 4 articles. Ultimately, 13 articles were selected for the qualitative analysis, and six articles were selected for the critical appraisal skills program. Conclusions: The development of new radionuclides and radiopharmaceuticals targeting CCR4 show promising results in the theranostics of CCR4 sensible tumors. Although to widen its use in clinical practice, further translation of preclinical to clinical data is needed.

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Section: Discussionmentioning

confidence: 99%

Novel Theranostic Approaches Targeting CCR4-Receptor, Current Status and Translational Prospectives: A Systematic Review

et al. 2023

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“…Superficial lymphoid infiltrate, epidermotropism with absent or rare spongiosis, and lymphoid atypia are the characteristic histological features of mycosis fungoides. [2][3][4] Precise clinicopathologic correlation is necessary to support a diagnosis, especially in the early stages of disease. In addition to the identification of histopathologic criteria, ancillary studies, including the identification of CD4(+) T cells with aberrant immunophenotypes and T-cell receptor gene rearrangements within skin lesions and peripheral blood are used to support the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…1 Mycosis Fungoides is the most common cutaneous Tcell lymphoma. 2 Angioimmunoblastic T Cell Lymphoma represents 15-20% of all peripheral T cell lymphomas and 1-2% of all Non-Hodgkin lymphomas. Patients in the sixth and seventh decades are affected with slightly male predominance.…”

Section: Introductionmentioning

confidence: 99%

Unveiling the journey of diagnosing cutaneous lymphomas- A case series

Sandhya

Hegde²,

Prithal³

et al. 2022

ACHR

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Cutaneous manifestation of Non-Hodgkin lymphoma can histologically and clinically manifest as Mycosis fungoides or Vasculitis. Histopathologic features of cutaneous lymphoma show dense tumor with a “bottom heavy” configuration. Tumor comprises either large lymphoid cells or sheets of monotonous small lymphoid cells with plasmacytoid configuration. A detailed work up is mandatory to conclude the diagnosis and provide definitive treatment in cutaneous lymphomas. In our case series, we present and describe 5 cases of Non-Hodgkin lymphoma with cutaneous manifestations. Two cases of Angioimmunoblastic T Cell Lymphoma with clinical and histological presentation as vasculitis, 2 cases of Mycosis fungoides concluded as Human T-cell Lymphotrophic Virus (HTLV) positive Adult T Cell Lymphomas on evaluation, 1 case which was lost to follow up are discussed. Thus, this case series emphasizes on the need to do complete work up of cutaneous lymphomas.

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“…There is a controversy if syringotropic mycosis fungoides is a variant of folliculotropic mycosis fungoides or a distinct entity. 4 De Masson et al showed that, while in folliculotropic mycosis fungoides, the head and neck are commonly affected, in syringotropic form, nearly half of the patients present with punctate palmoplantar lesions. Furthermore, clinical course of syringotropic mycosis fungoides seems to be more indolent with better overall and disease-free survival.…”

Section: Ijdvlcommentioning

confidence: 99%