The histology of early necrectomy

Moserová, J; Houšková, E.

doi:10.1016/0305-4179(82)90110-3

Cited by 3 publications

(2 citation statements)

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“…The current study provides the first clinical and histological evidence that immediate debridement of burns may lessen scar formation. This was consistent with reepithelialization data from other porcine trials 27,29 . Moreover, these results were obtained from deep‐dermal‐partial thickness burns approximately 50 cm 2 in size, which required more than 3 weeks to heal with reepithelialization involving the proliferation and migration of keratinocytes from skin appendages in the deep dermis.…”

Section: Discussionsupporting

confidence: 89%

“…While being a standard practice for chronic ulcers and infectious incision wounds, surgical debridement alone without skin grafting is not routinely practiced for burn treatments, except on chemical burns, where wound healing is exceptionally slow otherwise 25,26 . In the past, several studies have evaluated the effect of early surgical debridement on thermal burn wound healing without skin grafts/skin substitutes in porcine and guinea‐pig models 27–29 . The conclusions from these studies, however, were not consistent.…”

Section: Discussionmentioning

confidence: 99%

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Conservative surgical debridement as a burn treatment: Supporting evidence from a porcine burn model

Wang

Kempf

Liu

et al. 2008

Wound Repair Regeneration

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In thermal deep-dermal burns, surgical debridement is normally used in conjunction with skin grafting or skin substitutes and debridement alone as a burn treatment is not usually practiced. The current study addresses whether or not debridement alone would enhance burn wound healing on small deep-dermal-partial thickness burns. This was a prospective and blinded experimental trial using a porcine deep-dermal-partial thickness burn model. Four burns, approximately 50 cm(2) in size, were created on each of eight pigs. Two burns from each pig were immediately surgically debrided and the other two were not debrided as the internal control. Hydrate gel together with paraffin gauze were used to cover the burns for four pigs and silver dressings for the other four. Clinical assessment of wound healing was conducted over a 6-week period. Skin samples were collected at the end of the experiment and histopathological evaluation was performed. The results show thinner scar formation and lower scar height in the debrided compared with nondebrided wounds in the hydrate gel/paraffin gauze groups. There were no statistically significant differences in wound healing assessment between the debrided and nondebrided wounds dressed with silver dressings. This study provides supporting evidence that immediate debridement with an appropriate dressing and without skin grafting may promote wound healing, suggesting its potential benefit for clinical patients.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%