The histology of the infectious fibroma in rabbits

Viral Diseases

“…The lesions differ only slightly from those in Sylvilagus rabbits, the principal difference being the absence of epidermal degeneration often observed in the latter species (Shope, 1932a). However, Ahlstrom (1938) described epidermal degeneration in European rabbits. Microscopic lesions in the natural outbreak of fibromatosis in European rabbits ranged from tumors resembling myxomas to typical fibromas (Joiner et al, 1971).…”

“…The gross and microscopic changes associated with fibroma virus infection in naturally and experimentally infected Sylvilagus rabbits and in experimentally infected European rabbits have been described by several workers (Ahlstrom, 1938;Andrewes, 1936;Dalmat and Stanton, 1959;Fisher, 1953;Grilli et al, 2003;Kilham and Fisher, 1954;Shope, 1932a;Yuill and Hanson, 1964). The pathological changes in the only reported natural outbreak of fibromatosis in European rabbits were described by Joiner et al (1971).…”

Shope fibroma virus keratitis and spontaneous cataracts in a domestic rabbit

“…Changes to the overlying epidermis become obvious at 3–5 weeks, with the formation of rete pegs and intracytoplasmic inclusions. As the lesions become more chronic, focal areas of necrosis become evident within the tumor and regression occurs 34,36,40,41 …”

Pox Viruses

“…Fibroma virus, which seems to have less predilection for epithelium. produces inclu sions in skin epithelium of rabbits [Ahlstrom (114)]. …”