The Histone Acetyltransferase MOF Promotes Induces Generation of Pluripotent Stem Cells

Mu, Xiaoqian; Yan, Shaohua; Fu, Changhao; Wei, Anhui

doi:10.1089/cell.2014.0102

Cited by 18 publications

(19 citation statements)

References 30 publications

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“…Mof deleted cells exhibit aberrant expression of the core transcription factors Nanog, Sox2 and Oct4 (86). More recently, MOF was shown to promote generation of iPS cells by interacting with the H3K4 methyltransferase Wdr5 to promote endogenous oct4 expression during the reprogramming process (87). …”

Section: Dna Damage Responsementioning

confidence: 99%

Pluripotent Stem Cells and DNA Damage Response to Ionizing Radiations

et al. 2016

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Pluripotent stem cells (PSCs) hold great promise in regenerative medicine, disease modeling, functional genomics, toxicological studies and cell-based therapeutics due to their unique characteristics of self-renewal and pluripotency. Novel methods for generation of pluripotent stem cells and their differentiation to the specialized cell types such as neuronal cells, myocardial cells, hepatocytes, and beta cells of the pancreas and many other cells of the body are constantly being refined. Pluripotent stem cell derived differentiated cells, including neuronal cells or cardiac cells are ideal for stem cell transplantation as autologous or allogeneic cells from healthy donors due to their minimum risks of rejection. DNA damage induced by ionizing radiation (IR), ultraviolet (UV) light, genotoxic stress, and other intrinsic and extrinsic factors trigger a series of biochemical reactions termed as DNA damage response (DDR). In order to maintain genomic stability, and avoid transmission of mutations into progenitors cells, stem cells have robust DNA damage response signaling – a contrast to somatic cells. Stem cell transplantation may over come the late effects related to radiation. This review will particularly focus on differential DNA damage response between stem cells and derived differentiated cells and the possible pathways that determine such differences.

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Section: Dna Damage Responsementioning

confidence: 99%

Pluripotent Stem Cells and DNA Damage Response to Ionizing Radiations

et al. 2016

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“…As mentioned above, Mof is needed to ensure proper chromatin organization and mESC-specific expression patterns through acetylation of H4K16 151 . Ectopic Mof expression also improves OSKM-mediated reprogramming of human fibroblasts, while knockdown of Mof abrogates the process 202 . Interestingly, both Mof mRNA and protein levels increase throughout reprogramming and peak in iPSCs, in a manner similar to the Nanog maturation marker 202 .…”

Section: Somatic Cell Reprogrammingmentioning

confidence: 97%

KATapulting toward Pluripotency and Cancer

Hirsch

Wrana

Dent

2017

Journal of Molecular Biology

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Development is generally regarded as a unidirectional process that results in the acquisition of specialized cell fates. During this process, cellular identity is precisely defined by signaling cues that tailor the chromatin landscape for cell-specific gene expression programs. Once established, these pathways and cell states are typically resistant to disruption. However, loss of cell identity occurs during tumor initiation and upon injury response. Moreover, terminally differentiated cells can be experimentally provoked to become pluripotent. Chromatin reorganization is key to the establishment of new gene expression signatures and thus new cell identity. Here we explore an emerging concept that lysine acetyltransferase enzymes drive cellular plasticity in the context of somatic cell reprogramming and tumorigenesis.

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“…Not surprising considering the role of MOF in maintaining ESC, iPSCs contain high levels of MOF mRNA and MOF protein which are dramatically up-regulated following reprogramming (41). MOF overexpression has been reported to improve reprogramming efficiency, thus facilitating formation of iPSCs, and depletion of MOF impairs iPSCs generation (41).…”

Section: Mof Is Critical For Embryogenesismentioning

confidence: 99%

Section: Mof Is Critical For Embryogenesismentioning

confidence: 99%

“…MOF overexpression has been reported to improve reprogramming efficiency, thus facilitating formation of iPSCs, and depletion of MOF impairs iPSCs generation (41). This is possibly due to MOF interaction with the H3K4 methyltransferase Wdr5 to promote endogenous Oct4 expression (stem cell factor) during the reprogramming process (41). The loss of MOF also results in autophagy as it is coupled to the reduction of H4K16ac, which is associated with the down regulation of autophagy-related genes (42).…”

Section: Mof Is Critical For Embryogenesismentioning

confidence: 99%

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A multifaceted role for MOF histone modifying factor in genome maintenance

Mujoo

Hunt

Horikoshi

et al. 2017

Mechanisms of Ageing and Development

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MOF (males absent on the first) was initially identified as a dosage compensation factor in Drosophila that acetylates lysine 16 of histone H4 (H4K16ac) and increased gene transcription from the single copy male X-chromosome. In humans, however, the ortholog of Drosophila MOF has been shown to interact with a range of proteins that extend its potential significance well beyond transcription. For example, recent results indicate MOF is an upstream regulator of the ATM (ataxia-telangiectasia mutated) protein, the loss of which is responsible for ataxia telangiectasia (AT). ATM is a key regulatory kinase that interacts with and phosphorylates multiple substrates that influence critical, cell-cycle control and DNA damage repair pathways in addition to other pathways. Thus, directly or indirectly, MOF may be involved in a wide range of cellular functions. This review will focus on the contribution of MOF to cellular DNA repair and new results that are beginning to examine the in vivo physiological role of MOF.

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The Histone Acetyltransferase MOF Promotes Induces Generation of Pluripotent Stem Cells

Cited by 18 publications

References 30 publications

Pluripotent Stem Cells and DNA Damage Response to Ionizing Radiations

Pluripotent Stem Cells and DNA Damage Response to Ionizing Radiations

KATapulting toward Pluripotency and Cancer

A multifaceted role for MOF histone modifying factor in genome maintenance

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